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Early Stage Breast Cancer clinical trials
14 of 22 indexed Early Stage Breast Cancer trials are currently recruiting.
22 US clinical trials · 14 currently recruiting
Early Stage Breast Cancer is the subject of 22 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is Dana-Farber Cancer Institute, running 3 of these trials.
The research picture
Early Stage Breast Cancer has 22 registered US clinical trials, 14 of them open to new participants right now, about 64% of the total.
- 14
- recruiting participants now
- 64%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Dana-Farber Cancer Institute
Active & Recent Trials
22 total, page 1 of 1
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
QuantumLeap Healthcare Collaborative
NCT01042379
Registry for Intra-Operative Radiotherapy During Breast Conserving Surgery in Patients With Early Stage Breast Cancer
Saint John's Cancer Institute
NCT04603209
Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies
Tempus AI
NCT07211178
Cardiometabolic Screening Program
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT05386719
Exercise Therapy to Improve Cardiovascular Health in Post-Menopausal Women After Treatment for Early Stage Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT04458532
Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)
UNC Lineberger Comprehensive Cancer Center
NCT06902311
Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer
Jonsson Comprehensive Cancer Center
NCT04553770
Evaluating the Use of a Medication 'Switch' vs Guideline-directed Interventions for Relieving Side Effects of Aromatase Inhibitors Among Breast Cancer Patients
Dartmouth-Hitchcock Medical Center
NCT07071038
Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 Targeted
Rutgers, The State University of New Jersey
NCT05559164
Outcomes and Cosmesis With Whole Breast Irradiation and Boost
University of Wisconsin, Madison
NCT06295744
Portable Scalp Cooling System (PSCS) to Prevent Hair Loss for Breast Cancer Patients (Cooler Heads)
University of California, San Francisco
NCT06215469
BRE-04: Window of Opportunity Trial of Preoperative Low Dose Azacitidine in High-Risk Early Stage Breast Cancer
University of Illinois at Chicago
NCT04891068
Gut Microbiome, Adverse Effects, and Markers Through MEtabolic Reprogramming
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT06536881
SABER Study for Selected Early Stage Breast Cancer
University of Miami
NCT04360330
A Registry of Intra-Operative Radiation Therapy (IORT) Using the Xoft ® Axxent ® eBx ™ System Patients
MedStar Franklin Square Medical Center
NCT03561454
IORT-Breast at Medical Center Navicent Health
Wake Forest University Health Sciences
NCT04595435
TRADE: Dose Escalation Tolerability of Abemaciclib in HR+ HER2- Early Stage Breast Cancer
Dana-Farber Cancer Institute
NCT06001762
Phase I Dose Escalation of Single Fraction Adjuvant Stereotactic Body Partial Breast Irradiation Early Stage Breast CA
University of Texas Southwestern Medical Center
NCT02685332
Avoiding Growth Factor During Paclitaxel Treatment in Breast Cancer
Dana-Farber Cancer Institute
NCT02698891
Tangential Radiation Therapy Without Axillary Dissection in Breast Cancer
Dana-Farber Cancer Institute
NCT00165243
POWER-remote Weight Loss Program in Early Stage Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT01871116
Cyberknife® Partial Breast Irradiation (PBI) for Early Stage Breast Cancer
University of Texas Southwestern Medical Center
NCT01162200
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Early Stage Breast Cancer Trial Landscape
22 indexed Early Stage Breast Cancer studies · 14 recruiting (64%).
Phase mix: 0 late (III/IV) vs 11 early (I/II).
Top sponsor: Dana-Farber Cancer Institute (3 trials), 9 others listed. 22 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Early Stage Breast Cancer?
PlainTrial tracks 22 US clinical trials for Early Stage Breast Cancer, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Early Stage Breast Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.