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ClinicalTrials.gov 14 recruiting now official registry

Early Stage Breast Cancer clinical trials

14 of 22 indexed Early Stage Breast Cancer trials are currently recruiting.

22 US clinical trials · 14 currently recruiting

Early Stage Breast Cancer is the subject of 22 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is Dana-Farber Cancer Institute, running 3 of these trials.

The research picture

Early Stage Breast Cancer has 22 registered US clinical trials, 14 of them open to new participants right now, about 64% of the total.

14
recruiting participants now
64%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: Dana-Farber Cancer Institute
Phase 12Phase 29

Active & Recent Trials

22 total, page 1 of 1

RECRUITING Phase 2 5,000 participants

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

QuantumLeap Healthcare Collaborative

NCT01042379

RECRUITING 1,000 participants

Registry for Intra-Operative Radiotherapy During Breast Conserving Surgery in Patients With Early Stage Breast Cancer

Saint John's Cancer Institute

NCT04603209

RECRUITING 900 participants

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

Tempus AI

NCT07211178

RECRUITING NA 450 participants

Cardiometabolic Screening Program

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05386719

RECRUITING NA 152 participants

Exercise Therapy to Improve Cardiovascular Health in Post-Menopausal Women After Treatment for Early Stage Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT04458532

RECRUITING Phase 2 90 participants

Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)

UNC Lineberger Comprehensive Cancer Center

NCT06902311

RECRUITING Phase 2 88 participants

Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer

Jonsson Comprehensive Cancer Center

NCT04553770

RECRUITING Phase 2 62 participants

Evaluating the Use of a Medication 'Switch' vs Guideline-directed Interventions for Relieving Side Effects of Aromatase Inhibitors Among Breast Cancer Patients

Dartmouth-Hitchcock Medical Center

NCT07071038

RECRUITING Phase 2 60 participants

Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 Targeted

Rutgers, The State University of New Jersey

NCT05559164

RECRUITING NA 50 participants

Outcomes and Cosmesis With Whole Breast Irradiation and Boost

University of Wisconsin, Madison

NCT06295744

RECRUITING NA 40 participants

Portable Scalp Cooling System (PSCS) to Prevent Hair Loss for Breast Cancer Patients (Cooler Heads)

University of California, San Francisco

NCT06215469

RECRUITING Phase 2 40 participants

BRE-04: Window of Opportunity Trial of Preoperative Low Dose Azacitidine in High-Risk Early Stage Breast Cancer

University of Illinois at Chicago

NCT04891068

RECRUITING NA 30 participants

Gut Microbiome, Adverse Effects, and Markers Through MEtabolic Reprogramming

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06536881

RECRUITING NA 18 participants

SABER Study for Selected Early Stage Breast Cancer

University of Miami

NCT04360330

ACTIVE NOT RECRUITING 100 participants

A Registry of Intra-Operative Radiation Therapy (IORT) Using the Xoft ® Axxent ® eBx ™ System Patients

MedStar Franklin Square Medical Center

NCT03561454

ACTIVE NOT RECRUITING 94 participants

IORT-Breast at Medical Center Navicent Health

Wake Forest University Health Sciences

NCT04595435

ACTIVE NOT RECRUITING Phase 2 90 participants

TRADE: Dose Escalation Tolerability of Abemaciclib in HR+ HER2- Early Stage Breast Cancer

Dana-Farber Cancer Institute

NCT06001762

ACTIVE NOT RECRUITING Phase 1 30 participants

Phase I Dose Escalation of Single Fraction Adjuvant Stereotactic Body Partial Breast Irradiation Early Stage Breast CA

University of Texas Southwestern Medical Center

NCT02685332

COMPLETED Phase 2 127 participants

Avoiding Growth Factor During Paclitaxel Treatment in Breast Cancer

Dana-Farber Cancer Institute

NCT02698891

COMPLETED Phase 2 100 participants

Tangential Radiation Therapy Without Axillary Dissection in Breast Cancer

Dana-Farber Cancer Institute

NCT00165243

COMPLETED NA 96 participants

POWER-remote Weight Loss Program in Early Stage Breast Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT01871116

COMPLETED Phase 1 75 participants

Cyberknife® Partial Breast Irradiation (PBI) for Early Stage Breast Cancer

University of Texas Southwestern Medical Center

NCT01162200

Reading the Early Stage Breast Cancer Trial Landscape

22 indexed Early Stage Breast Cancer studies · 14 recruiting (64%).

Phase mix: 0 late (III/IV) vs 11 early (I/II).

Top sponsor: Dana-Farber Cancer Institute (3 trials), 9 others listed. 22 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Early Stage Breast Cancer?

PlainTrial tracks 22 US clinical trials for Early Stage Breast Cancer, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Early Stage Breast Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.