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Early Stage Breast Cancer: early-phase trial registry
14 of 22 indexed Early Stage Breast Cancer trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #756 of 28,707 conditions by registered trial count.
22 US clinical trials · 14 currently recruiting · #756 of 28,707 conditions by registered trial count
Early Stage Breast Cancer: 22 US clinical trials tracked, 14 recruiting.
Early Stage Breast Cancer is the subject of 22 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is Dana-Farber Cancer Institute, running 3 of these trials.
Enrollment posture brief
Registry condition early-stage-breast-cancer
OPEN 14 | RECR 64% | LATE 0 | EARLY 11 | RANK #756 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Autoimmune Disease (64% recruiting · 11 trials)
Early Stage Breast Cancer lists 14 open slots (64% of 22 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Early Stage Breast Cancer on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Early Stage Breast Cancer is recruiting above its size-band peers.
14 of 22 indexed trials (63.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Early Stage Breast Cancer trials is spread across many organizations.
Dana-Farber Cancer Institute accounts for 3 of 22 trials (13.6%). 17 distinct sponsors appear on at least one study for this condition label.
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Most Early Stage Breast Cancer trials plan to enrol fewer than 100 people.
Median target enrolment is 90 among the 22 trials that report a genuine target (sentinel values excluded). 14 of those (63.6%) plan for fewer than 100 participants.
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Early Stage Breast Cancer research is mostly interventional.
18 interventional and 4 observational studies make up this index (81.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
22 total, page 1 of 1
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
QuantumLeap Healthcare Collaborative
NCT01042379
Registry for Intra-Operative Radiotherapy During Breast Conserving Surgery in Patients With Early Stage Breast Cancer
Saint John's Cancer Institute
NCT04603209
Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies
Tempus AI
NCT07211178
Cardiometabolic Screening Program
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT05386719
Exercise Therapy to Improve Cardiovascular Health in Post-Menopausal Women After Treatment for Early Stage Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT04458532
Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)
UNC Lineberger Comprehensive Cancer Center
NCT06902311
Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer
Jonsson Comprehensive Cancer Center
NCT04553770
Evaluating the Use of a Medication 'Switch' vs Guideline-directed Interventions for Relieving Side Effects of Aromatase Inhibitors Among Breast Cancer Patients
Dartmouth-Hitchcock Medical Center
NCT07071038
Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 Targeted
Rutgers, The State University of New Jersey
NCT05559164
Outcomes and Cosmesis With Whole Breast Irradiation and Boost
University of Wisconsin, Madison
NCT06295744
Portable Scalp Cooling System (PSCS) to Prevent Hair Loss for Breast Cancer Patients (Cooler Heads)
University of California, San Francisco
NCT06215469
BRE-04: Window of Opportunity Trial of Preoperative Low Dose Azacitidine in High-Risk Early Stage Breast Cancer
University of Illinois at Chicago
NCT04891068
Gut Microbiome, Adverse Effects, and Markers Through MEtabolic Reprogramming
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT06536881
SABER Study for Selected Early Stage Breast Cancer
University of Miami
NCT04360330
A Registry of Intra-Operative Radiation Therapy (IORT) Using the Xoft ® Axxent ® eBx ™ System Patients
MedStar Franklin Square Medical Center
NCT03561454
IORT-Breast at Medical Center Navicent Health
Wake Forest University Health Sciences
NCT04595435
TRADE: Dose Escalation Tolerability of Abemaciclib in HR+ HER2- Early Stage Breast Cancer
Dana-Farber Cancer Institute
NCT06001762
Phase I Dose Escalation of Single Fraction Adjuvant Stereotactic Body Partial Breast Irradiation Early Stage Breast CA
University of Texas Southwestern Medical Center
NCT02685332
Avoiding Growth Factor During Paclitaxel Treatment in Breast Cancer
Dana-Farber Cancer Institute
NCT02698891
Tangential Radiation Therapy Without Axillary Dissection in Breast Cancer
Dana-Farber Cancer Institute
NCT00165243
POWER-remote Weight Loss Program in Early Stage Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT01871116
Cyberknife® Partial Breast Irradiation (PBI) for Early Stage Breast Cancer
University of Texas Southwestern Medical Center
NCT01162200
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 9 |
Top Sponsors
Named interventions
Most-linked intervention names on Early Stage Breast Cancer records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Early Stage Breast Cancer trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Early Stage Breast Cancer page
22 registered trials, 14 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 14 Early Stage Breast Cancer trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Dana-Farber Cancer Institute sponsors the most Early Stage Breast Cancer trials on record, review their full trial history before evaluating a specific study. See Dana-Farber Cancer Institute's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Early Stage Breast Cancer condition card totals 22 registered trials; most-linked intervention Anastrozole; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.