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ClinicalTrials.gov 53 recruiting now official registry

Diffuse Large B Cell Lymphoma clinical trials

53 of 115 indexed Diffuse Large B Cell Lymphoma trials are currently recruiting.

115 US clinical trials · 53 currently recruiting

Diffuse Large B Cell Lymphoma is the subject of 115 registered US clinical trials on ClinicalTrials.gov, 53 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 88 in Phase 1-2 (earlier-stage). The most active sponsor is Genmab, running 6 of these trials.

The research picture

Diffuse Large B Cell Lymphoma has 115 registered US clinical trials, 53 of them open to new participants right now, about 46% of the total.

53
recruiting participants now
46%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
6
top sponsor: Genmab
Phase 158Phase 230Phase 311

Active & Recent Trials

115 total, page 3 of 3

COMPLETED Phase 2 61 participants

SAR3419 as Single Agent in Relapsed-Refractory Diffuse Large B-Cell Lymphoma (DLBCL) Patients

Sanofi

NCT01472887

COMPLETED Phase 2 52 participants

Rituximab Plus CHOP With Sargramostim in Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma

University of Southern California

NCT00599170

COMPLETED Phase 1 50 participants

Oral Clofarabine for Relapsed/Refractory Non-Hodgkin Lymphoma

Massachusetts General Hospital

NCT00644189

COMPLETED NA 46 participants

Use of a Patient Preferences Shared Decision-Making Encounter Tool in Clinical Practice for Patients With DLBCL and FL

Carevive Systems

NCT04160442

COMPLETED Phase 1 39 participants

Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL

Masonic Cancer Center, University of Minnesota

NCT03019666

COMPLETED Phase 1 39 participants

A Study to Evaluate Safety, Pharmacokinetics, and Clinical Activity of Combination of RO6870810 and Venetoclax, With or Without Rituximab, in Participants With Relapsed/Refractory DLBCL and/or High-Grade B-Cell Lymphoma and/or High Grade B-Cell Lymphoma With MYC and/or BCL2 and/or BCL6

Hoffmann-La Roche

NCT03255096

COMPLETED Phase 1 26 participants

BR101801 in Adult Patients With Advanced Hematologic Malignancies(Phase I)

Boryung Pharmaceutical Co.

NCT04018248

COMPLETED Phase 2 23 participants

Bendamustine + Rituximab in Older Patients With Previously Untreated Diffuse Large B-cell Lymphoma

UNC Lineberger Comprehensive Cancer Center

NCT01234467

COMPLETED Phase 2 22 participants

Imexon for Relapsed Follicular and Aggressive Lymphomas

University of Rochester

NCT01314014

COMPLETED Phase 1 22 participants

Phase 1/2 Study of VSLI Plus Rituximab in Patients With Relapsed and/or Refractory NHL

Acrotech Biopharma

NCT01851551

COMPLETED Early Phase 1 15 participants

Molecular Monitoring With Circulating Tumor DNA and Nivolumab Maintenance

Fox Chase Cancer Center

NCT03311958

COMPLETED Phase 1 12 participants

Combination Chemotherapy and TAK-659 as Front-Line Treatment in Treating Patients With High-Risk Diffuse Large B Cell Lymphoma

Northwestern University

NCT03742258

COMPLETED NA 10 participants

Adaptive Bridging RT in R/R B-cell Lymphoma (Pre-CAR T)

Massachusetts General Hospital

NCT06004167

COMPLETED Phase 1 7 participants

Safety, PK/PD, and Clinical Activity of KT-413 in Adult Patients with Relapsed or Refractory B-cell NHL

Kymera Therapeutics

NCT05233033

COMPLETED Phase 1 6 participants

TC-110 T Cells in Adults With Relapsed or Refractory Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia

TCR2 Therapeutics

NCT04323657

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Phase Distribution

PhaseTrial count
Phase 1 58
Phase 2 30
Phase 3 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diffuse Large B Cell Lymphoma Trial Landscape

115 indexed Diffuse Large B Cell Lymphoma studies · 53 recruiting (46%).

Phase mix: 11 late (III/IV) vs 88 early (I/II).

Top sponsor: Genmab (6 trials), 9 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diffuse Large B Cell Lymphoma?

PlainTrial tracks 115 US clinical trials for Diffuse Large B Cell Lymphoma, of which 53 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diffuse Large B Cell Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.