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ClinicalTrials.gov 10 recruiting now official registry

Diabetic Macular Edema clinical trials

10 of 64 indexed Diabetic Macular Edema trials are currently recruiting.

64 US clinical trials · 10 currently recruiting

Diabetic Macular Edema is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 18 are in Phase 3-4 (later-stage) and 38 in Phase 1-2 (earlier-stage). The most active sponsor is Hoffmann-La Roche, running 5 of these trials.

The research picture

Diabetic Macular Edema has 64 registered US clinical trials, 10 of them open to new participants right now, about 16% of the total.

10
recruiting participants now
16%
of trials open to enrollment
18
in Phase 3–4 (later-stage)
5
top sponsor: Hoffmann-La Roche
Phase 123Phase 215Phase 311Phase 47

Active & Recent Trials

64 total, page 2 of 2

COMPLETED Phase 4 30 participants

Ocular Safety and Usability Study for FYB203 PFS

Formycon

NCT06708637

COMPLETED Phase 4 30 participants

IAI for Persistent DME After Treatment With Bevacizumab And Ranibizumab

Southeast Retina Center, Georgia

NCT03340610

COMPLETED Phase 1 29 participants

Efficacy & Safety Trial of Intravitreal Injections Combined With PRP for CSME Secondary to Diabetes Mellitus (DAVE)

David M. Brown, M.D.

NCT01552408

COMPLETED Phase 2 27 participants

Study of EYP-1901 in Patients With Diabetic Macular Edema (DME)

EyePoint Pharmaceuticals

NCT06099184

COMPLETED Phase 2 25 participants

Oxulumis® Suprachoroidal Microcatherization of Triesence® in Diabetic Macular Edema

Oxular Limited

NCT05512962

COMPLETED Phase 1 25 participants

The Effect of Intravitreal Ranibizumab on Visual Acuity and Hard Exudate Resolution in the Treatment of Diabetic Macular Edema With Center Involved Edema and Lipid Exudates

South Coast Retina Center; Carson, McBeath, Boswell

NCT02448446

COMPLETED Phase 1 21 participants

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IVT MHU650 in Macular Edema Patients

Novartis Pharmaceuticals

NCT04635800

COMPLETED Phase 1 20 participants

Safety and Tolerability of NOVA63035 "Corticosteroid" in Patients With Diabetic Macular Edema Secondary to Diabetic Retinopathy

Santen SAS

NCT00665106

COMPLETED Phase 1 20 participants

Suprachoroidal Injection of CLS-TA Alone or With Aflibercept in Subjects With Diabetic Macular Edema

Clearside Biomedical

NCT02949024

COMPLETED Phase 1 14 participants

A Phase I Single Ascending Dose Study of the Intravitreal Plasma Kallikrein Inhibitor KVD001 in Subjects With DME

KalVista Pharmaceuticals

NCT02193113

COMPLETED Phase 1 12 participants

A Study to Evaluate the Safety of THR-687 in Subjects With Diabetic Macular Edema (DME)

ThromboGenics

NCT03666923

COMPLETED Phase 1 12 participants

A Study to Evaluate the Safety of THR-149 in Subjects With Diabetic Macular Edema (DME)

ThromboGenics

NCT03511898

COMPLETED Phase 4 10 participants

Analysis of Cytokines in Response to Treatment of Diabetic Macular Edema With 0.3mg Lucentis

Vitreo-Retinal Associates, Michigan

NCT03097068

COMPLETED Phase 1 4 participants

Near-infrared Light (NIR) Therapy for Diabetic Macular Edema: A Pilot Study

Medical College of Wisconsin

NCT00846092

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Phase Distribution

PhaseTrial count
Phase 1 23
Phase 2 15
Phase 3 11
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetic Macular Edema Trial Landscape

64 indexed Diabetic Macular Edema studies · 10 recruiting (16%).

Phase mix: 18 late (III/IV) vs 38 early (I/II).

Top sponsor: Hoffmann-La Roche (5 trials), 9 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetic Macular Edema?

PlainTrial tracks 64 US clinical trials for Diabetic Macular Edema, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetic Macular Edema?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.