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2026 data Public-data reference. official source

Depression, Postpartum

Open-data reference.

16 US clinical trials · 5 currently recruiting

Active & Recent Trials

RECRUITING 200 participants

A Study to Learn More About How Zuranolone Affects Postpartum Depression Symptoms in Participants Who Took it Within 1 Year After The End of Their Pregnancy

Biogen

NCT07047820

RECRUITING NA 156 participants

Healing at Home 2.0 - Enhanced Chat Tool for Lowering Postpartum Depression

University of Pennsylvania

NCT06877104

RECRUITING Phase 2 150 participants

Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women

Cedars-Sinai Medical Center

NCT05552053

RECRUITING NA 100 participants

IMAGINE: Pilot Trial of a Digital Group Intervention to Prevent Perinatal Depression

University of Washington

NCT06746337

RECRUITING NA 50 participants

HeartGPS: A Study Exploring the Effects of a Psychological Intervention for Parents and Their Babies After Prenatal Cardiac Diagnosis

Children's Hospital Medical Center, Cincinnati

NCT06175104

ACTIVE NOT RECRUITING NA 20 participants

Enhancing Mental and Physical Health of Women Veterans

VA Office of Research and Development

NCT05050266

COMPLETED NA 590 participants

Using a Preparation and Education Intervention to Reduce Postpartum Depression Among New Mothers (The MADE IT 2 Study)

Icahn School of Medicine at Mount Sinai

NCT00951717

COMPLETED NA 248 participants

Doula Support for Young Mothers: A Randomized Trial

University of Chicago

NCT01925664

COMPLETED Phase 4 238 participants

Effectiveness of Supplemental Calcium in Preventing Postpartum Depression

Oregon Health and Science University

NCT00228033

COMPLETED NA 177 participants

Madres Para la Salud (Mothers for Health)

Arizona State University

NCT01908959

COMPLETED Phase 2 162 participants

Effectiveness of Sertraline Alone and Interpersonal Psychotherapy Alone in Treating Women With Postpartum Depression

Women and Infants Hospital of Rhode Island

NCT00602355

COMPLETED Phase 2 109 participants

Inhaled Oxytocin and HPA Axis Reactivity

University of North Carolina, Chapel Hill

NCT03593473

COMPLETED Phase 2 93 participants

A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression

DuKang Pharmaceuticals

NCT06285916

COMPLETED NA 70 participants

Meditation for NICU Moms

St. Louis University

NCT03574766

COMPLETED NA 61 participants

CSE v. Epidural for Postpartum Depression

Grace Lim, MD, MS

NCT03022526

COMPLETED NA 31 participants

Tracking Depression Symptoms With a Health Chatbot

University of Chicago

NCT03990389

Phase Distribution

PhaseTrial count
Phase 2 4
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Depression, Postpartum Trial Landscape

ClinicalTrials.gov lists 16 US studies indexed under Depression, Postpartum, and 5 of those are currently open to recruitment — roughly 31% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Depression, Postpartum shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Depression, Postpartum is led by University of Chicago with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 16 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Depression, Postpartum?

PlainTrial tracks 16 US clinical trials for Depression, Postpartum, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Depression, Postpartum?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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