Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Critically Ill: early-phase trial registry
2 of 8 indexed Critically Ill trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #2,176 of 28,707 conditions by registered trial count.
8 US clinical trials · 2 currently recruiting · #2,176 of 28,707 conditions by registered trial count
Critically Ill: 8 US clinical trials tracked, 2 recruiting.
Critically Ill is the subject of 8 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is David Leaf, running 1 of these trials.
Enrollment posture brief
Registry condition critically-ill
OPEN 2 | RECR 25% | LATE 0 | EARLY 2 | RANK #2176 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Abdominal Pain (25% recruiting · 20 trials)
Critically Ill lists 2 open slots (25% of 8 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Critically Ill on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Critically Ill is recruiting below its size-band peers.
2 of 8 indexed trials (25%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Critically Ill trials is spread across many organizations.
David Leaf accounts for 1 of 8 trials (12.5%). 8 distinct sponsors appear on at least one study for this condition label.
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Typical Critically Ill enrolment sits around 150 participants.
Median target enrolment is 150 among the 8 trials that report a genuine target (sentinel values excluded). 4 of those (50%) plan for fewer than 100 participants.
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Critically Ill splits between interventional and observational designs.
5 interventional and 3 observational studies make up this index (62.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
8 total, page 1 of 1
Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
Duke University
NCT05055830
Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients
Zeliha Alicikus
NCT07222007
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness
Sunnybrook Health Sciences Centre
NCT03005145
Managing Acute Pain in Critically Ill Non-communicative Palliative Care Patients
University of Maryland, Baltimore
NCT02127086
Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury
David Leaf
NCT02962102
Safety and Feasibility of Kefir Administration in Critically Ill Adults
Mayo Clinic
NCT05416814
New Stable Isotope Method to Determine Protein Requirements in Critically Ill Children
Texas A&M University
NCT01511354
A Randomized, Controlled Trial of Inspiratory Muscle Training (IMT)in the ICU and CCU
Wake Forest University Health Sciences
NCT02003053
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Critically Ill records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Critically Ill trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Critically Ill page
8 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 2 Critically Ill trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- David Leaf sponsors the most Critically Ill trials on record, review their full trial history before evaluating a specific study. See David Leaf's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Critically Ill condition card totals 8 registered trials; most-linked intervention Calcifediol; top US site state North Carolina. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.