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Critically Ill clinical trials
Every US clinical trial registered for Critically Ill — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
8 US clinical trials · 2 currently recruiting
The research picture
Critically Ill has 8 registered US clinical trials, 2 of them open to new participants right now — about 25% of the total.
- 2
- recruiting participants now
- 25%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 1
- top sponsor: David Leaf
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
Duke University
NCT05055830
Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients
Zeliha Alicikus
NCT07222007
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness
Sunnybrook Health Sciences Centre
NCT03005145
Managing Acute Pain in Critically Ill Non-communicative Palliative Care Patients
University of Maryland, Baltimore
NCT02127086
Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury
David Leaf
NCT02962102
Safety and Feasibility of Kefir Administration in Critically Ill Adults
Mayo Clinic
NCT05416814
New Stable Isotope Method to Determine Protein Requirements in Critically Ill Children
Texas A&M University
NCT01511354
A Randomized, Controlled Trial of Inspiratory Muscle Training (IMT)in the ICU and CCU
Wake Forest University Health Sciences
NCT02003053
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Critically Ill Trial Landscape
ClinicalTrials.gov lists 8 US studies indexed under Critically Ill, and 2 of those are currently open to recruitment — roughly 25% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Critically Ill shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Critically Ill is led by David Leaf with 1 indexed trial, alongside 7 other organizations in the top contributor list. The list on this page surfaces up to 8 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Critically Ill?
PlainTrial tracks 8 US clinical trials for Critically Ill, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Critically Ill?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.