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NCT01511354 · ClinicalTrials.gov registry record
New Stable Isotope Method to Determine Protein Requirements in Critically Ill Children
A clinical trial of Critically Ill, sponsored by Texas A&M University.
- Completed
- Registry status
- 12
- Enrollment target
- 1
- Study location
NCT01511354 is a study of Critically Ill that has completed, run by Texas A&M University. The registered enrollment target is 12 participants, below the 888-participant average among 7 other Critically Ill trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.
The verdict
NCT01511354, a study of Critically Ill, has completed, sponsored by Texas A&M University.
- COMPLETED
- Registry status
- 12 participants
- Enrollment target
- 1
- Study location
Study Summary
The need for certain components of food (i.e. protein) for critically ill children is not clear. It is important to have critically ill children fed adequately to prevent that their condition becomes worse or that recovery takes longer. Research methods used in the past to investigate the need for protein (Nitrogen Balance calculations), were not sensitive enough in severely ill children. The purpose of this study is to develop a new research method to determine the need for protein in severely ill children. In order to develop this new method, more information is needed on the way the body of these children uses protein in 24-hours. In the present study during 24-hours 8 children of age less than 18 years who are admitted to either the Pediatric ICU or the Cardiovascular ICU. Subjects will receive a standard nutrition, providing an age specific amount of protein (age ≤ 3: 2.52 protein g/kg BW.d; age 4-6: 1.8 protein g/kg BW.d; age \> 10: 1.44 protein g/kg BW.d) via tube feeding. They will also receive a mixture of stable isotopes of amino to investigate protein behavior in the body (protein kinetics) both by infusion in their blood and together with the nutrition. Blood will be drawn every 60 minutes during the 24-hour period and the behavior of protein and the concentrations in blood of amino acids and urea will be measured. Urine will be collected to measure nitrogen balance. The investigators will compare the results of this nitrogen balance method with the results of the stable isotope method. PIM2, PRISM, SIRS criteria will be used to get information on the severity of illness of the subjects. Also body weight and length as well as body composition of the subjects will be measured at the start and after the 24-hour period. Body composition will be measured by Bioelectrical Impedance Spectroscopy. Endpoints of the study are net whole-body protein synthesis (protein balance), 24-hour pattern of protein balance, 24-hour urea production, 24-hour nitrogen balance,
Conditions Studied
Study Locations (1)
Arkansas
- Arkansas Children's Hospital - Little Rock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2008-02 |
| Est. Completion | 2013-01 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01511354
The ClinicalTrials.gov registry entry for NCT01511354 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 888-participant average among 7 other Critically Ill trials with a reported enrollment target (99% lower). The listed sponsor is Texas A&M University, which has 95 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Critically Ill appearing as the primary indexed condition, and to 0 interventions.
NCT01511354 reports 1 study location spanning 1 distinct geographic area - top geographies include Arkansas.
Frequently Asked Questions
What is clinical trial NCT01511354 about?
NCT01511354 is a clinical study titled "New Stable Isotope Method to Determine Protein Requirements in Critically Ill Children". The need for certain components of food (i.e. protein) for critically ill children is not clear. It is important to have critically ill children fed adequately to prevent that their condition becomes worse or that recovery takes longer. Research methods used in the past to investigate the need for p...
What is the current status of trial NCT01511354?
This trial is currently completed. The enrollment target is 12 participants. The study started on 2008-02. Estimated completion is 2013-01.
What conditions does trial NCT01511354 study?
This clinical trial studies the following conditions: Critically Ill.
Who is sponsoring clinical trial NCT01511354?
This trial is sponsored by Texas A&M University, which has 95 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01511354 being conducted?
This trial has 1 study location across Arkansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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