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ClinicalTrials.gov 12 recruiting now official registry

Cigarette Smoking-Related Carcinoma clinical trials

12 of 22 indexed Cigarette Smoking-Related Carcinoma trials are currently recruiting.

22 US clinical trials · 12 currently recruiting

Cigarette Smoking-Related Carcinoma is the subject of 22 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Ohio State University Comprehensive Cancer Center, running 6 of these trials.

The research picture

Cigarette Smoking-Related Carcinoma has 22 registered US clinical trials, 12 of them open to new participants right now, about 55% of the total.

12
recruiting participants now
55%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
6
top sponsor: Ohio State University Comprehensive Cancer Center
Phase 12Phase 22Phase 32Phase 41

Active & Recent Trials

22 total, page 1 of 1

RECRUITING Phase 4 2,010 participants

Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial

M.D. Anderson Cancer Center

NCT04604509

RECRUITING NA 1,500 participants

A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior

Ohio State University Comprehensive Cancer Center

NCT06260683

RECRUITING NA 1,000 participants

Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia

Ohio State University Comprehensive Cancer Center

NCT06763536

RECRUITING NA 776 participants

A Digital Smoking Cessation Intervention for Helping American Indians and Alaska Natives Quit Smoking, IndigeQuit Trial

Fred Hutchinson Cancer Center

NCT06145763

RECRUITING Phase 3 600 participants

Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program

Alliance for Clinical Trials in Oncology

NCT05008848

RECRUITING NA 298 participants

Smoking Cessation Intervention Development for Homeless Youth

Ohio State University Comprehensive Cancer Center

NCT06754215

RECRUITING 150 participants

Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study)

Roswell Park Cancer Institute

NCT07167225

RECRUITING NA 147 participants

CONNECTing to LungCare

University of California, San Francisco

NCT06213532

RECRUITING Phase 2 135 participants

Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers

National Cancer Institute (NCI)

NCT05121051

RECRUITING 40 participants

Understanding Tobacco and Cannabis Co-Use Practices: Initiation, Escalation, and Maintenance

Roswell Park Cancer Institute

NCT07439471

RECRUITING Early Phase 1 30 participants

Sensory Tests of Cigarettes for Identification of Flavors in Current Daily Smoking Adults

Roswell Park Cancer Institute

NCT06816459

RECRUITING NA 30 participants

Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences

Ohio State University Comprehensive Cancer Center

NCT07111234

ACTIVE NOT RECRUITING Phase 3 1,647 participants

An Innovative Conversational Agent (Quitbot) for Smoking Cessation

Fred Hutchinson Cancer Center

NCT04308759

ACTIVE NOT RECRUITING NA 191 participants

Increasing Access to Smoking Cessation and Smoke Free Home Services for Low-Income Pregnant Women in Northeast Texas

M.D. Anderson Cancer Center

NCT05051345

ACTIVE NOT RECRUITING 182 participants

Impact of E-cigarette Use on the Body

Ohio State University Comprehensive Cancer Center

NCT04972513

ACTIVE NOT RECRUITING NA 104 participants

Evaluating the Episodic Future Thinking Intervention for Reducing Cigarette Consumption in Cigarette Smokers

Roswell Park Cancer Institute

NCT05825001

ACTIVE NOT RECRUITING Phase 2 41 participants

Evaluation of Canakinumab in High-Risk Former-Smokers

Peter Shields

NCT06038526

COMPLETED NA 500 participants

Pilot Trial of a Game Embedded in a Smartphone App for Smoking Cessation

University of California, San Francisco

NCT05227027

COMPLETED 182 participants

Electronic Cigarette Use During Pregnancy

UConn Health

NCT03480373

COMPLETED NA 169 participants

Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes

M.D. Anderson Cancer Center

NCT03856515

COMPLETED Phase 1 53 participants

Website Smoking Cessation Intervention for the Promotion of Smoking Cessation in Low-Income Veterans

Fred Hutchinson Cancer Center

NCT04502524

COMPLETED NA 27 participants

Evaluating the Impact of Quitting Using Executive Function Strategy Training (QUEST) on Smoking Cessation in Homeless Young Adult Smokers

Ohio State University Comprehensive Cancer Center

NCT06745154

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 2
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cigarette Smoking-Related Carcinoma Trial Landscape

22 indexed Cigarette Smoking-Related Carcinoma studies · 12 recruiting (55%).

Phase mix: 3 late (III/IV) vs 4 early (I/II).

Top sponsor: Ohio State University Comprehensive Cancer Center (6 trials), 8 others listed. 22 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cigarette Smoking-Related Carcinoma?

PlainTrial tracks 22 US clinical trials for Cigarette Smoking-Related Carcinoma, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cigarette Smoking-Related Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.