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NCT05121051 · ClinicalTrials.gov registry record · Phase 2
Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers
A Phase 2 study of Cigarette Smoking-Related Carcinoma, sponsored by National Cancer Institute (NCI).
- Recruiting
- Registry status
- Phase 2
- Development phase
- 135
- Enrollment target
- 3
- Study locations
NCT05121051: Recruiting Phase 2 study of Cigarette Smoking-Related Carcinoma, sponsored by National Cancer Institute (NCI).
NCT05121051 is a Phase 2 study of Cigarette Smoking-Related Carcinoma that is actively recruiting participants, run by National Cancer Institute (NCI). The registered enrollment target is 135 participants, below the 461-participant average among 21 other Cigarette Smoking-Related Carcinoma trials with a reported enrollment target (71% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05121051, a Phase 2 study of Cigarette Smoking-Related Carcinoma, is actively recruiting participants, sponsored by National Cancer Institute (NCI).
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 135 participants
- Enrollment target
- 3
- Study locations
Study Summary
This phase II trial tests whether broccoli seed and sprout extract works to break down cancer causing substances of tobacco in heavy smokers. Smokers are at increased risk for developing lung, head and neck, and other cancers. Broccoli seed and sprout extract may help break down and remove toxic substances caused by tobacco use and possibly produce substances that may protect cells from tobacco smoke-induced damage in current smokers.
Primary Outcome
Measured by changes in the urinary levels of their respective mercapturic acids, SPMA and 3-HPMA, from baseline.
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- OTHER Questionnaire Administration
- DRUG Placebo Administration
- DIETARY_SUPPLEMENT Broccoli Sprout/Broccoli Seed Extract Supplement
Study Locations (3)
Arizona
- University of Arizona Cancer Center - Prevention Research Clinic - Tucson
District of Columbia
- George Washington University Medical Center - Washington D.C.
New York
- Roswell Park Cancer Institute - Buffalo
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 135 participants |
| Start Date | 2022-09-21 |
| Est. Completion | 2027-12-31 |
| Phase | Phase 2 |
What NCT05121051 shows while recruiting
NCT05121051 is an interventional study that assigns participants to a tested intervention. The registered 135 participants enrollment target is mid-sized for trials with a published cap, below the 461-participant average among 21 other Cigarette Smoking-Related Carcinoma trials with a reported enrollment target (71% lower).
The record links to 1 condition, with Cigarette Smoking-Related Carcinoma appearing as the primary indexed condition, and to 4 interventions - of which Biospecimen Collection is the first listed.
NCT05121051 reports a single indexed study location in Arizona, District of Columbia, New York.
Frequently Asked Questions
What is clinical trial NCT05121051 about?
NCT05121051 is a clinical study titled "Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers". This phase II trial tests whether broccoli seed and sprout extract works to break down cancer causing substances of tobacco in heavy smokers. Smokers are at increased risk for developing lung, head and neck, and other cancers. Broccoli seed and sprout extract may help break down and remove toxic sub...
What is the current status of trial NCT05121051?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 135 participants. The study started on 2022-09-21. Estimated completion is 2027-12-31.
What conditions does trial NCT05121051 study?
This clinical trial studies the following conditions: Cigarette Smoking-Related Carcinoma.
What interventions are being tested in trial NCT05121051?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Questionnaire Administration (OTHER), Placebo Administration (DRUG), Broccoli Sprout/Broccoli Seed Extract Supplement (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT05121051?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05121051 being conducted?
This trial has 3 study locations across Arizona, District of Columbia, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cigarette Smoking-Related Carcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05121051's enrollment target sits among peer trials
135 15th of 21 higher than 7 of 21 other Cigarette Smoking-Related Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cigarette Smoking-Related Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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