Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06763536 · ClinicalTrials.gov registry record · NA
Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia
A NA study of Cigarette Smoking-Related Carcinoma, sponsored by Ohio State University Comprehensive Cancer Center.
- Recruiting
- Registry status
- NA
- Development phase
- 1,000
- Enrollment target
- 1
- Study location
NCT06763536: Recruiting NA study of Cigarette Smoking-Related Carcinoma, sponsored by Ohio State University Comprehensive Cancer Center.
NCT06763536 is a NA study of Cigarette Smoking-Related Carcinoma that is actively recruiting participants, run by Ohio State University Comprehensive Cancer Center. The registered enrollment target is 1,000 participants, above the 420-participant average among 21 other Cigarette Smoking-Related Carcinoma trials with a reported enrollment target (138% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06763536, a NA study of Cigarette Smoking-Related Carcinoma, is actively recruiting participants, sponsored by Ohio State University Comprehensive Cancer Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 1,000 participants
- Enrollment target
- 1
- Study location
Study Summary
This clinical trial compares the use of oral nicotine pouches to nicotine replacement therapy, consisting of nicotine patches and lozenges, to reduce cigarette use in smokers living in rural Appalachia. The lung and oral cancers that plague Appalachia are fueled by cigarette smoking. Oral nicotine pouches which contain nicotine but no tobacco leaf, present a new opportunity to reduce cancer risk among Appalachian adults who smoke. Oral nicotine pouches and nicotine replacement therapy may work well to reduce cigarette use for smokers in rural Appalachia.
Primary Outcome
Statistical analyses will be performed using SAS 9.4. P-values less than 0.05 will be considered statistically significant. Will be presented as frequencies and proportions and compared with chi-squared tests.
Conditions Studied
Interventions
- OTHER Survey Administration
- OTHER Carbon Monoxide Measurement
- OTHER Nicotine Lozenge
- OTHER Oral Nicotine Pouch
- OTHER Nicotine Patch
Study Locations (1)
Ohio
- Ohio State University Comprehensive Cancer Center - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 2025-06-13 |
| Est. Completion | 2028-12-31 |
| Phase | NA |
What NCT06763536 shows while recruiting
NCT06763536 is an interventional study that assigns participants to a tested intervention. Its 1,000 participants enrollment target places it among the larger protocols in the corpus, above the 420-participant average among 21 other Cigarette Smoking-Related Carcinoma trials with a reported enrollment target (138% higher).
The record links to 1 condition, with Cigarette Smoking-Related Carcinoma appearing as the primary indexed condition, and to 5 interventions - of which Survey Administration is the first listed.
NCT06763536 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT06763536 about?
NCT06763536 is a clinical study titled "Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia". This clinical trial compares the use of oral nicotine pouches to nicotine replacement therapy, consisting of nicotine patches and lozenges, to reduce cigarette use in smokers living in rural Appalachia. The lung and oral cancers that plague Appalachia are fueled by cigarette smoking. Oral nicotine p...
What is the current status of trial NCT06763536?
This trial is currently recruiting. It is a NA study. The enrollment target is 1,000 participants. The study started on 2025-06-13. Estimated completion is 2028-12-31.
What conditions does trial NCT06763536 study?
This clinical trial studies the following conditions: Cigarette Smoking-Related Carcinoma.
What interventions are being tested in trial NCT06763536?
The interventions under investigation include: Survey Administration (OTHER), Carbon Monoxide Measurement (OTHER), Nicotine Lozenge (OTHER), Oral Nicotine Pouch (OTHER), Nicotine Patch (OTHER).
Who is sponsoring clinical trial NCT06763536?
This trial is sponsored by Ohio State University Comprehensive Cancer Center, which has 341 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06763536 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cigarette Smoking-Related Carcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06763536's enrollment target sits among peer trials
1,000 4th of 21 higher than 18 of 21 other Cigarette Smoking-Related Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cigarette Smoking-Related Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Digital Smoking Cessation Intervention for Helping American Indians and Alaska Natives Quit Smoking, IndigeQuit Trial
RECRUITING · NA
-
CONNECTing to LungCare
RECRUITING · NA
-
Smoking Cessation Intervention Development for Homeless Youth
RECRUITING · NA
-
Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences
RECRUITING · NA
-
A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior
RECRUITING · NA
-
Evaluating the Episodic Future Thinking Intervention for Reducing Cigarette Consumption in Cigarette Smokers
ACTIVE NOT RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00018044 · 1,000 participants
Study of Mycobacterial Infections
- NCT01036581 · 1,000 participants · NA
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
- NCT01192048 · 1,000 participants
Genetics of Congenital Heart Disease
- NCT01553214 · 1,000 participants · Phase 4
Improving White Blood Cell Collection From Healthy Donors
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI