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ClinicalTrials.gov 5 recruiting now official registry

Chronic Heart Failure clinical trials

5 of 13 indexed Chronic Heart Failure trials are currently recruiting.

13 US clinical trials · 5 currently recruiting

Chronic Heart Failure is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Nile Therapeutics, running 1 of these trials.

The research picture

Chronic Heart Failure has 13 registered US clinical trials, 5 of them open to new participants right now, about 38% of the total.

5
recruiting participants now
38%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
1
top sponsor: Nile Therapeutics
Phase 11Phase 22Phase 31

Active & Recent Trials

13 total, page 1 of 1

RECRUITING Phase 3 1,900 participants

Multi-center Trial of Ferric Derisomaltose Versus no Intravenous Iron in Iron-deficient Subjects With Symptomatic Chronic Heart Failure

Pharmacosmos A/S

NCT06929806

RECRUITING NA 1,500 participants

The HEARTFELT Study

Heartfelt Technologies

NCT06222099

RECRUITING NA 150 participants

Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment

XSpline S.p.A.

NCT05327062

RECRUITING NA 136 participants

Mindful Steps 2.0: Promoting Physical Activity in Patients With COPD and HF

Beth Israel Deaconess Medical Center

NCT05934565

RECRUITING NA 40 participants

Reducing Fluid Overload in Heart Failure Patients Using a Non-invasive, Renal Independent System

AquaPass Medical

NCT06360380

ACTIVE NOT RECRUITING Phase 2 314 participants

Evaluate Efficacy, Safety and Tolerability of JTT-861 in Subjects With Heart Failure With Reduced Ejection Fraction

Akros Pharma

NCT06017609

ACTIVE NOT RECRUITING 300 participants

Destination Therapy Post Approval Study

Medtronic Cardiac Rhythm and Heart Failure

NCT03681210

ACTIVE NOT RECRUITING 216 participants

R&D Study to Evaluate Cordio's Usability and to Collect Patient Speech Utterances

Cordio Medical

NCT05876533

COMPLETED NA 247 participants

Cost and Shared Decision-Making for Heart Failure

Emory University

NCT04793880

COMPLETED NA 104 participants

Telehealth Management in HF Disparity Patients

Northwell Health

NCT02196922

COMPLETED 77 participants

Iron Deficiency and FGF23 Regulation in CKD and HF

Northwestern University

NCT03106298

COMPLETED Phase 1 58 participants

PK/PD Study of Subcutaneous Cenderitide Infusion in CHF Patients

Nile Therapeutics

NCT01316432

COMPLETED Phase 2 25 participants

A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00094562

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 2
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Heart Failure Trial Landscape

13 indexed Chronic Heart Failure studies · 5 recruiting (38%).

Phase mix: 1 late (III/IV) vs 3 early (I/II).

Top sponsor: Nile Therapeutics (1 trial), 9 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Heart Failure?

PlainTrial tracks 13 US clinical trials for Chronic Heart Failure, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Heart Failure?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.