Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 20 recruiting now official registry

Cataract clinical trials

20 of 85 indexed Cataract trials are currently recruiting.

85 US clinical trials · 20 currently recruiting

Cataract is the subject of 85 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 30 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Alcon Research, running 12 of these trials.

The research picture

Cataract has 85 registered US clinical trials, 20 of them open to new participants right now, about 24% of the total.

20
recruiting participants now
24%
of trials open to enrollment
30
in Phase 3–4 (later-stage)
12
top sponsor: Alcon Research
Phase 14Phase 21Phase 310Phase 420

Active & Recent Trials

85 total, page 2 of 2

COMPLETED 101 participants

Effect of Intraocular Lens (IOL) Centration and Tilt on Visual Performance With Clareon® Vivity® IOL Implantation

East Coast Institute for Research

NCT05827133

COMPLETED NA 100 participants

Assessment of Low Energy Lens Fragmentation Cataract Extraction in Patients Undergoing Cataract Surgery

Carl Zeiss Meditec

NCT04747834

COMPLETED Phase 4 96 participants

Ocular Tissue Levels of 1.5% Levofloxacin Ophthalmic Solution Compared to an Active Comparator

Santen

NCT00630019

COMPLETED 96 participants

Cataract Surgery to Obtain Human Lens Material for the Study of Nuclear Cataracts

National Eye Institute (NEI)

NCT00001613

COMPLETED NA 94 participants

Femtosecond Laser Assisted Keratotomies for the Management of Corneal Astigmatism

Milton S. Hershey Medical Center

NCT04676451

COMPLETED 89 participants

Evaluation of the EpiGlare Tester for the Measurement of Glare-Induced Changes in BSCVA in Subjects With and Without Cataracts

Epico

NCT04739397

COMPLETED NA 84 participants

Conventional Surgery vs. Verion/VerifEye

Carolina Eyecare Physicians

NCT02513745

COMPLETED Phase 4 80 participants

Efficacy of Dextenza Insert in Upper vs Lower Punctum Following Cataract Surgery With PCIOL.

Iworks Laser and Vision Center

NCT05372315

COMPLETED NA 75 participants

Monofocal IOL Visual Outcomes When Targeting Mini Monovision

Carolina Eyecare Physicians

NCT05069415

COMPLETED NA 71 participants

Rotational Stability of the AcrySof® Toric

Alcon Research

NCT00762216

COMPLETED NA 70 participants

A Comparison of Corneal Aberrations in Subjects With Contralateral AcrySof IQ Toric Intraocular Lens (IOL) and AcrySof IQ IOL With Limbal Relaxing Incision (LRI)

Alcon Research

NCT01045733

COMPLETED Phase 4 65 participants

A Comparison of Visual Function After Bilateral Implantation of Presbyopia-correcting Intraocular Lenses (IOLs)

Alcon Research

NCT01166971

COMPLETED Phase 3 65 participants

A Study Assessing the Safety and Efficacy of Dextenza® for the Treatment of Ocular Pain and Inflammation Following Surgery for Pediatric Cataract

Ocular Therapeutix

NCT04539548

COMPLETED Phase 4 64 participants

Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery

Alcon Research

NCT00870103

COMPLETED Phase 4 64 participants

Symfony vs Vivity in Dim Light

Carolina Eyecare Physicians

NCT06229106

COMPLETED Phase 4 59 participants

Dropless vs. Standard Drops Contralateral Eye Study

Carolina Eyecare Physicians

NCT02515045

COMPLETED NA 54 participants

Post-market Study to Obtain Surgeon Feedback on Clinical Outcome in Eyes Implanted With TECNIS Toric II IOL

Johnson & Johnson Surgical Vision

NCT04210232

COMPLETED 50 participants

Clinical Comparison of Length of Cataract Procedures With Zeiss Lumera Versus Older Zeiss Microscope

Toyos Clinic

NCT03298841

COMPLETED Phase 4 48 participants

Bioavailability of Bimatoprost Ophthalmic Solution in Human Aqueous.

Indiana University School of Medicine

NCT00355446

COMPLETED Phase 4 48 participants

Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs

Indiana University School of Medicine

NCT00392275

COMPLETED NA 41 participants

Intraocular Steroid After Cataract Surgery Study

Dean Health System

NCT00478764

COMPLETED Phase 4 40 participants

Evaluation of Effective Lens Position With a Uniplanar Bi-aspheric IOL

Lenstec Incorporated

NCT01248572

COMPLETED Phase 4 40 participants

Investigate, Following Cataract Surgery With IOL in Conjunction With Intracanalicular Dexamethasone Insert

Wolstan and Goldberg Eye Associates

NCT04465864

COMPLETED 40 participants

Veracity Surgical: A Time/Motion and Quality of Care Study

Research Insight

NCT04337892

COMPLETED 40 participants

Clinical Outcomes With Bilateral Implantation of Odyssey IOLs

Mann Eye Institute

NCT06550375

COMPLETED Phase 4 35 participants

Prophylactic Treatment: Lessdrops™ vs Standard Drops Regimen

Carolina Eyecare Physicians

NCT03578276

COMPLETED NA 35 participants

Visual Function and Patient Satisfaction After Bilateral Implantation of AcrySof Natural ReSTOR (Model SN60D3) or AcrySof Natural Monofocal (Model SN60AT)

Alcon Research

NCT00759668

COMPLETED 30 participants

Evaluation of Quality of Vision and Visual Outcomes With Bilateral Implantation of the Clareon PanOptix Intraocular Lens

Newsom Eye & Laser Center

NCT05518539

COMPLETED Phase 4 26 participants

The Evaluation of Balanced Salt Solution During Cataract Surgery

Adam Fedyk, MD, FACS

NCT05853978

COMPLETED 25 participants

Binocular Custom Vision Utilizing The Light Adjustable Lens (LAL)

Vance Thompson Vision

NCT04533191

COMPLETED 20 participants

Evaluation of the Aspheric ReSTOR IOL After Routine Cataract Extraction

Medical University of South Carolina

NCT00720005

COMPLETED 20 participants

Refractive and Visual Outcomes With the ARGOS Biometer In Eyes With a History of Refractive Surgery: ARGOS Study

Vance Thompson Vision

NCT07129980

COMPLETED Early Phase 1 10 participants

Netarsudil Use After Descemetorhexis Without Endothelial Keratoplasty

Massachusetts Eye and Ear Infirmary

NCT04057053

COMPLETED 10 participants

Test of QLS Device to Detect Early Cataracts

National Eye Institute (NEI)

NCT00001617

COMPLETED Phase 4

Ketorolac vs. Steroid in the Prevention of CME

Innovative Medical

NCT00348244

← Previous Page 2 of 2

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 1
Phase 3 10
Phase 4 20

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cataract Trial Landscape

85 indexed Cataract studies · 20 recruiting (24%).

Phase mix: 30 late (III/IV) vs 5 early (I/II).

Top sponsor: Alcon Research (12 trials), 9 others listed. 35 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cataract?

PlainTrial tracks 85 US clinical trials for Cataract, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cataract?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.