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Cataract clinical trials
20 of 85 indexed Cataract trials are currently recruiting.
85 US clinical trials · 20 currently recruiting
Cataract is the subject of 85 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 30 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Alcon Research, running 12 of these trials.
The research picture
Cataract has 85 registered US clinical trials, 20 of them open to new participants right now, about 24% of the total.
- 20
- recruiting participants now
- 24%
- of trials open to enrollment
- 30
- in Phase 3–4 (later-stage)
- 12
- top sponsor: Alcon Research
Active & Recent Trials
85 total, page 2 of 2
Effect of Intraocular Lens (IOL) Centration and Tilt on Visual Performance With Clareon® Vivity® IOL Implantation
East Coast Institute for Research
NCT05827133
Assessment of Low Energy Lens Fragmentation Cataract Extraction in Patients Undergoing Cataract Surgery
Carl Zeiss Meditec
NCT04747834
Ocular Tissue Levels of 1.5% Levofloxacin Ophthalmic Solution Compared to an Active Comparator
Santen
NCT00630019
Cataract Surgery to Obtain Human Lens Material for the Study of Nuclear Cataracts
National Eye Institute (NEI)
NCT00001613
Femtosecond Laser Assisted Keratotomies for the Management of Corneal Astigmatism
Milton S. Hershey Medical Center
NCT04676451
Evaluation of the EpiGlare Tester for the Measurement of Glare-Induced Changes in BSCVA in Subjects With and Without Cataracts
Epico
NCT04739397
Conventional Surgery vs. Verion/VerifEye
Carolina Eyecare Physicians
NCT02513745
Efficacy of Dextenza Insert in Upper vs Lower Punctum Following Cataract Surgery With PCIOL.
Iworks Laser and Vision Center
NCT05372315
Monofocal IOL Visual Outcomes When Targeting Mini Monovision
Carolina Eyecare Physicians
NCT05069415
Rotational Stability of the AcrySof® Toric
Alcon Research
NCT00762216
A Comparison of Corneal Aberrations in Subjects With Contralateral AcrySof IQ Toric Intraocular Lens (IOL) and AcrySof IQ IOL With Limbal Relaxing Incision (LRI)
Alcon Research
NCT01045733
A Comparison of Visual Function After Bilateral Implantation of Presbyopia-correcting Intraocular Lenses (IOLs)
Alcon Research
NCT01166971
A Study Assessing the Safety and Efficacy of Dextenza® for the Treatment of Ocular Pain and Inflammation Following Surgery for Pediatric Cataract
Ocular Therapeutix
NCT04539548
Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery
Alcon Research
NCT00870103
Symfony vs Vivity in Dim Light
Carolina Eyecare Physicians
NCT06229106
Dropless vs. Standard Drops Contralateral Eye Study
Carolina Eyecare Physicians
NCT02515045
Post-market Study to Obtain Surgeon Feedback on Clinical Outcome in Eyes Implanted With TECNIS Toric II IOL
Johnson & Johnson Surgical Vision
NCT04210232
Clinical Comparison of Length of Cataract Procedures With Zeiss Lumera Versus Older Zeiss Microscope
Toyos Clinic
NCT03298841
Bioavailability of Bimatoprost Ophthalmic Solution in Human Aqueous.
Indiana University School of Medicine
NCT00355446
Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs
Indiana University School of Medicine
NCT00392275
Intraocular Steroid After Cataract Surgery Study
Dean Health System
NCT00478764
Evaluation of Effective Lens Position With a Uniplanar Bi-aspheric IOL
Lenstec Incorporated
NCT01248572
Investigate, Following Cataract Surgery With IOL in Conjunction With Intracanalicular Dexamethasone Insert
Wolstan and Goldberg Eye Associates
NCT04465864
Veracity Surgical: A Time/Motion and Quality of Care Study
Research Insight
NCT04337892
Clinical Outcomes With Bilateral Implantation of Odyssey IOLs
Mann Eye Institute
NCT06550375
Prophylactic Treatment: Lessdrops™ vs Standard Drops Regimen
Carolina Eyecare Physicians
NCT03578276
Visual Function and Patient Satisfaction After Bilateral Implantation of AcrySof Natural ReSTOR (Model SN60D3) or AcrySof Natural Monofocal (Model SN60AT)
Alcon Research
NCT00759668
Evaluation of Quality of Vision and Visual Outcomes With Bilateral Implantation of the Clareon PanOptix Intraocular Lens
Newsom Eye & Laser Center
NCT05518539
The Evaluation of Balanced Salt Solution During Cataract Surgery
Adam Fedyk, MD, FACS
NCT05853978
Binocular Custom Vision Utilizing The Light Adjustable Lens (LAL)
Vance Thompson Vision
NCT04533191
Evaluation of the Aspheric ReSTOR IOL After Routine Cataract Extraction
Medical University of South Carolina
NCT00720005
Refractive and Visual Outcomes With the ARGOS Biometer In Eyes With a History of Refractive Surgery: ARGOS Study
Vance Thompson Vision
NCT07129980
Netarsudil Use After Descemetorhexis Without Endothelial Keratoplasty
Massachusetts Eye and Ear Infirmary
NCT04057053
Test of QLS Device to Detect Early Cataracts
National Eye Institute (NEI)
NCT00001617
Ketorolac vs. Steroid in the Prevention of CME
Innovative Medical
NCT00348244
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 1 |
| Phase 3 | 10 |
| Phase 4 | 20 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cataract Trial Landscape
85 indexed Cataract studies · 20 recruiting (24%).
Phase mix: 30 late (III/IV) vs 5 early (I/II).
Top sponsor: Alcon Research (12 trials), 9 others listed. 35 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cataract?
PlainTrial tracks 85 US clinical trials for Cataract, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cataract?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.