Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor
NCT04008797 · View on ClinicalTrials.gov ↗
Study Summary
The primary objective of this study is to assess the safety and tolerability and to determine the recommended Phase 2 dose (RP2D) of E7386 in combination with other anticancer drug(s), and to determine the optimal dose of E7386 in combination with lenvatinib in endometrial carcinoma (EC) (for EC Dose Optimization Part only).
Conditions Studied
Interventions
- DRUG Doxorubicin
- DRUG Paclitaxel
- DRUG Lenvatinib
- DRUG E7386
Study Locations (20)
California
- University of California San Diego (UCSD) - Moores Cancer Center(All) — La Jolla
- Cedars-Sinai Medical Center — Los Angeles
- Pasadena Liver Center — Pasadena
- California Pacific Medical Center — San Francisco
- UCLA University of California - Los Angeles — Santa Monica
- John Muir Clinical Research — Walnut Creek
Florida
- Uni. Of Miami- Sylvester Cancer Centre — Miami
- Florida Cancer Specialists - South — Sarasota
- Florida Cancer Specialists - East — West Palm Beach
New York
- Perlmutter Cancer Center- NYU Langone Health — New York
- Memorial Sloan Kettering Cancer Center — New York
- Montefiore Medical Center (MMC) - Jack D. Weiler Hospital — The Bronx
Ohio
- MetroHealth Medical Center — Cleveland
- ProMedica Flower Hospital — Sylvania
Arkansas
- UAMS — Little Rock
Colorado
- University of Colorado Cancer Center - Anschutz Medical Campus — Aurora
Louisiana
- Women's Cancer Care - Covington, LA — Covington
Mississippi
- University Of Mississippi Medical Center — Jackson
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 301 participants |
| Start Date | 2019-07-11 |
| Est. Completion | 2027-03-31 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04008797
The ClinicalTrials.gov registry entry for NCT04008797 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 301 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eisai, which has 71 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 5 conditions, with Neoplasms appearing as the primary indexed condition, and to 4 interventions — of which Doxorubicin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04008797 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Florida, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04008797 about?
NCT04008797 is a clinical study titled "A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor". The primary objective of this study is to assess the safety and tolerability and to determine the recommended Phase 2 dose (RP2D) of E7386 in combination with other anticancer drug(s), and to determine the optimal dose of E7386 in combination with lenvatinib in endometrial carcinoma (EC) (for EC Dos...
What is the current status of trial NCT04008797?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 301 participants. The study started on 2019-07-11. Estimated completion is 2027-03-31.
What conditions does trial NCT04008797 study?
This clinical trial studies the following conditions: Neoplasms, Colorectal Neoplasms, Carcinoma, Hepatocellular, Endometrial Neoplasms, Liver Neoplasms. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04008797?
The interventions under investigation include: Doxorubicin (DRUG), Paclitaxel (DRUG), Lenvatinib (DRUG), E7386 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04008797?
This trial is sponsored by Eisai, which has 71 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04008797 being conducted?
This trial has 20 study locations across Arkansas, California, Colorado, Florida, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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