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NCT00105443 · ClinicalTrials.gov registry record · Phase 3
A Phase III Study of Sorafenib in Patients With Advanced Hepatocellular Carcinoma
A Phase 3 study of Carcinoma, Hepatocellular, sponsored by Bayer.
- Completed
- Registry status
- Phase 3
- Development phase
- 602
- Enrollment target
- 20
- Study locations
NCT00105443: Completed Phase 3 study of Carcinoma, Hepatocellular, sponsored by Bayer.
NCT00105443 is a Phase 3 study of Carcinoma, Hepatocellular that has completed, run by Bayer. The registered enrollment target is 602 participants, roughly in line with the 590-participant average among 27 other Carcinoma, Hepatocellular trials with a reported enrollment target. The trial reports 20 study locations across 9 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00105443, a Phase 3 study of Carcinoma, Hepatocellular, has completed, sponsored by Bayer.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 602 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of the study is: Find out if patients receiving sorafenib will live longer. Find out if sorafenib has any effect on patient reported outcomes. Find out if sorafenib prevents the growth of or shrinks liver tumors and/or their metastases. Determine the pharmacokinetics (PK) in patients with liver cancer.
Primary Outcome
Overall Survival was defined as the time from date of starting treatment to death due to any cause. Subjects still alive at the time of analysis were censored at their last date of last contact.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Sorafenib (Nexavar, BAY43-9006)
Study Locations (20)
California
- - Los Angeles
- - Los Angeles
- - Orange
- - San Francisco
- - Stanford
Florida
- - Gainesville
- - Miami
- - Tampa
Arizona
- - Phoenix
- - Tucson
Connecticut
- - Farmington
- - New Haven
Georgia
- - Atlanta
- - Atlanta
Illinois
- - Chicago
- - Chicago
Michigan
- - Ann Arbor
- - Detroit
Kentucky
- - Lexington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 602 participants |
| Start Date | 2005-03 |
| Est. Completion | 2008-11 |
| Phase | Phase 3 |
What the finished NCT00105443 record still lists
NCT00105443 is an interventional study that assigns participants to a tested intervention. The registered 602 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 590-participant average among 27 other Carcinoma, Hepatocellular trials with a reported enrollment target.
The record links to 1 condition, with Carcinoma, Hepatocellular appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT00105443 names 20 study sites across 9 states, led by California, Florida, Arizona.
Frequently Asked Questions
What is clinical trial NCT00105443 about?
NCT00105443 is a clinical study titled "A Phase III Study of Sorafenib in Patients With Advanced Hepatocellular Carcinoma". The purpose of the study is: Find out if patients receiving sorafenib will live longer. Find out if sorafenib has any effect on patient reported outcomes. Find out if sorafenib prevents the growth of or shrinks liver tumors and/or their metastases. Determine the pharmacokinetics (PK) in patients wit...
What is the current status of trial NCT00105443?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 602 participants. The study started on 2005-03. Estimated completion is 2008-11.
What conditions does trial NCT00105443 study?
This clinical trial studies the following conditions: Carcinoma, Hepatocellular.
What interventions are being tested in trial NCT00105443?
The interventions under investigation include: Placebo (DRUG), Sorafenib (Nexavar, BAY43-9006) (DRUG).
Who is sponsoring clinical trial NCT00105443?
This trial is sponsored by Bayer, which has 591 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00105443 being conducted?
This trial has 20 study locations across Arizona, California, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Carcinoma, Hepatocellular
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00105443's enrollment target sits among peer trials
602 7th of 27 higher than 21 of 27 other Carcinoma, Hepatocellular trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Carcinoma, Hepatocellular trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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