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ACTIVE NOT RECRUITING Phase 3

A Study of Atezolizumab Plus Bevacizumab Versus Active Surveillance as Adjuvant Therapy in Patients With Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation

NCT04102098 · View on ClinicalTrials.gov ↗

Study Summary

This study will evaluate the efficacy and safety of adjuvant therapy with atezolizumab plus bevacizumab compared with active surveillance in participants with completely resected or ablated hepatocellular carcinoma (HCC) who are at high risk for disease recurrence.

Conditions Studied

Interventions

  • DRUG Bevacizumab
  • DRUG Atezolizumab

Study Locations (20)

Other

  • Lkh-Univ. Klinikum Graz — Graz
  • Klinikum Klagenfurt am Wörtersee — Klagenfurt
  • Medizinische Universität Wien — Vienna
  • Imeldaziekenhuis — Bonheiden
  • AZ Delta (Campus Rumbeke) — Roeselare

Texas

  • The University of Texas Southwestern Medical Center at Dallas — Dallas
  • MD Anderson Cancer Center — Houston

California

  • Kaiser Permanente Los Angeles — Los Angeles

Maryland

  • Mercy Medical Center — Baltimore

Michigan

  • Henry Ford Health System — Detroit

New York

  • Columbia University Medical Center — New York

Pennsylvania

  • Thomas Jefferson University — Philadelphia

Washington

  • Swedish Cancer Inst. — Seattle

Trial Details

FieldValue
Enrollment Target 668 participants
Start Date 2019-12-31
Est. Completion 2026-05-15
Phase Phase 3

Sponsor

Hoffmann-La Roche

758 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04102098

The ClinicalTrials.gov registry entry for NCT04102098 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 668 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Carcinoma, Hepatocellular appearing as the primary indexed condition, and to 2 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04102098 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Other, Texas, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04102098 about?

NCT04102098 is a clinical study titled "A Study of Atezolizumab Plus Bevacizumab Versus Active Surveillance as Adjuvant Therapy in Patients With Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation". This study will evaluate the efficacy and safety of adjuvant therapy with atezolizumab plus bevacizumab compared with active surveillance in participants with completely resected or ablated hepatocellular carcinoma (HCC) who are at high risk for disease recurrence.

What is the current status of trial NCT04102098?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 668 participants. The study started on 2019-12-31. Estimated completion is 2026-05-15.

What conditions does trial NCT04102098 study?

This clinical trial studies the following conditions: Carcinoma, Hepatocellular. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04102098?

The interventions under investigation include: Bevacizumab (DRUG), Atezolizumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04102098?

This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04102098 being conducted?

This trial has 20 study locations across California, Maryland, Michigan, New York, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial