Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 10 recruiting now official registry

BRCA2 Mutation clinical trials

10 of 15 indexed BRCA2 Mutation trials are currently recruiting.

15 US clinical trials · 10 currently recruiting

BRCA2 Mutation is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Abramson Cancer Center at Penn Medicine, running 2 of these trials.

The research picture

BRCA2 Mutation has 15 registered US clinical trials, 10 of them open to new participants right now, about 67% of the total.

10
recruiting participants now
67%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: Abramson Cancer Center at Penn Medicine
Phase 16Phase 21

Active & Recent Trials

15 total, page 1 of 1

RECRUITING NA 1,000 participants

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results

Memorial Sloan Kettering Cancer Center

NCT05420064

RECRUITING NA 820 participants

FaCT Trial (Facilitated Cascade Testing Trial)

Weill Medical College of Cornell University

NCT04613440

RECRUITING 400 participants

Prostate Cancer Genetic Risk Evaluation and Screening Study

Massachusetts General Hospital

NCT05129605

RECRUITING Phase 1 120 participants

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

858 Therapeutics

NCT06395519

RECRUITING NA 50 participants

Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy

Duke University

NCT06972719

RECRUITING Phase 2 32 participants

Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With Select HRR Gene Alterations

Rana McKay, MD

NCT05498272

RECRUITING Phase 1 24 participants

SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells

General Oncology

NCT04150042

RECRUITING Phase 1 24 participants

Combination Therapy in Cancers With Mutations in DNA Repair Genes

University of California, San Francisco

NCT05694715

RECRUITING Phase 1 20 participants

Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer

Dana-Farber Cancer Institute

NCT06488378

RECRUITING Phase 1 18 participants

Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors

Pamela Munster

NCT06177171

ACTIVE NOT RECRUITING 5,412 participants

BRCA Founder OutReach (BFOR) Study

Memorial Sloan Kettering Cancer Center

NCT03351803

ACTIVE NOT RECRUITING 100 participants

Evaluating Cascade Communication Methods

University of Pennsylvania

NCT04428736

ACTIVE NOT RECRUITING 50 participants

BRCA1/2 Flu Vaccine

Abramson Cancer Center at Penn Medicine

NCT04499534

COMPLETED NA 276 participants

Decision Support for BRCA Testing in Ethnically Diverse Women

Columbia University

NCT03470402

COMPLETED Phase 1 9 participants

HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer

Abramson Cancer Center at Penn Medicine

NCT03685331

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the BRCA2 Mutation Trial Landscape

15 indexed BRCA2 Mutation studies · 10 recruiting (67%).

Phase mix: 0 late (III/IV) vs 7 early (I/II).

Top sponsor: Abramson Cancer Center at Penn Medicine (2 trials), 9 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for BRCA2 Mutation?

PlainTrial tracks 15 US clinical trials for BRCA2 Mutation, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for BRCA2 Mutation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.