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NCT05129605 · ClinicalTrials.gov registry record
Prostate Cancer Genetic Risk Evaluation and Screening Study
A clinical trial of Prostate Cancer and Lynch Syndrome, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- 400
- Enrollment target
- 1
- Study location
NCT05129605: Recruiting study of Prostate Cancer and Lynch Syndrome, sponsored by Massachusetts General Hospital.
NCT05129605 is a study of Prostate Cancer and Lynch Syndrome that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 400 participants, below the 608-participant average among 735 other Prostate Cancer trials with a reported enrollment target (34% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05129605, a study of Prostate Cancer and Lynch Syndrome, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- 400 participants
- Enrollment target
- 1
- Study location
Study Summary
This study aims to define the natural history of men at high genetic risk for prostate cancer on the basis of specific germline genetic mutations, family history, or Black/African ancestry and evaluate the utility of prostate MRI as a screening tool. The hypothesis is that this targeted population of men are at elevated risk of developing prostate cancer compared to the general population, and enhanced screening with MRI will enable early detection and diagnosis of potentially aggressive prostate cancer, characterization of the penetrance of specific mutations, and potentially identify new genetic risk mutations.
Primary Outcome
Diagnosis of overall and clinically significant (grade group 2 or higher) prostate cancer
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Prostate cancer screening
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2020-02-12 |
| Est. Completion | 2040-12 |
What NCT05129605 shows while recruiting
NCT05129605 is an observational study that tracks outcomes without assigning an intervention. The registered 400 participants enrollment target is mid-sized for trials with a published cap, below the 608-participant average among 735 other Prostate Cancer trials with a reported enrollment target (34% lower).
The record links to 8 conditions, with Prostate Cancer appearing as the primary indexed condition, and to 1 intervention - of which Prostate cancer screening is the first listed.
NCT05129605 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05129605 about?
NCT05129605 is a clinical study titled "Prostate Cancer Genetic Risk Evaluation and Screening Study". This study aims to define the natural history of men at high genetic risk for prostate cancer on the basis of specific germline genetic mutations, family history, or Black/African ancestry and evaluate the utility of prostate MRI as a screening tool. The hypothesis is that this targeted population o...
What is the current status of trial NCT05129605?
This trial is currently recruiting. The enrollment target is 400 participants. The study started on 2020-02-12. Estimated completion is 2040-12.
What conditions does trial NCT05129605 study?
This clinical trial studies the following conditions: Prostate Cancer, Lynch Syndrome, BRCA1 Mutation, BRCA2 Mutation, Genetic Predisposition to Disease.
What interventions are being tested in trial NCT05129605?
The interventions under investigation include: Prostate cancer screening (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05129605?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05129605 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Prostate Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05129605's enrollment target sits among peer trials
400 128th of 735 higher than 605 of 735 other Prostate Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Prostate Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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