Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 27 recruiting now official registry

Advanced Malignant Solid Neoplasm clinical trials

27 of 109 indexed Advanced Malignant Solid Neoplasm trials are currently recruiting.

109 US clinical trials · 27 currently recruiting

Advanced Malignant Solid Neoplasm is the subject of 109 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 99 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 67 of these trials.

The research picture

Advanced Malignant Solid Neoplasm has 109 registered US clinical trials, 27 of them open to new participants right now, about 25% of the total.

27
recruiting participants now
25%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
67
top sponsor: National Cancer Institute (NCI)
Phase 144Phase 255Phase 31

Active & Recent Trials

109 total, page 2 of 3

ACTIVE NOT RECRUITING Phase 2 54 participants

Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study

National Cancer Institute (NCI)

NCT03872427

ACTIVE NOT RECRUITING Phase 2 53 participants

Testing Binimetinib as a Potential Targeted Treatment in Cancers With NRAS Genetic Changes (MATCH-Subprotocol Z1A)

National Cancer Institute (NCI)

NCT04439344

ACTIVE NOT RECRUITING Phase 2 50 participants

Testing Trametinib as a Potential Targeted Treatment in Cancers With NF1 Genetic Changes (MATCH-Subprotocol S1)

National Cancer Institute (NCI)

NCT04439318

ACTIVE NOT RECRUITING Phase 1 50 participants

FID-007 in Treating Participants With Advanced Solid Tumors

University of Southern California

NCT03537690

ACTIVE NOT RECRUITING Phase 1 49 participants

EphA2 siRNA in Treating Patients With Advanced or Recurrent Solid Tumors

M.D. Anderson Cancer Center

NCT01591356

ACTIVE NOT RECRUITING Phase 2 49 participants

Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With TSC1 or TSC2 Genetic Changes (MATCH - Subprotocol M)

National Cancer Institute (NCI)

NCT06390865

ACTIVE NOT RECRUITING Phase 2 44 participants

Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Genetic Changes (MATCH - Subprotocol C1)

National Cancer Institute (NCI)

NCT06357975

ACTIVE NOT RECRUITING Phase 1 44 participants

Cabozantinib and Pamiparib for the Treatment of Advanced of Refractory Solid Tumors

M.D. Anderson Cancer Center

NCT05038839

ACTIVE NOT RECRUITING Phase 2 43 participants

Testing Palbociclib (PD-0332991) as Potentially Targeting Treatment in Cancers With CDK4 or CDK6 Amplification (MATCH - Subprotocol Z1C)

National Cancer Institute (NCI)

NCT06390839

ACTIVE NOT RECRUITING Phase 2 40 participants

Testing Afatinib as a Potential Targeted Treatment in Cancers With HER2 Genetic Changes (MATCH-Subprotocol B)

National Cancer Institute (NCI)

NCT04439136

ACTIVE NOT RECRUITING Phase 2 40 participants

Testing Palbociclib (PD-0332991) as a Potential Targeted Treatment in Cancers With CCND1, 2, 3 Amplification (MATCH-Subprotocol Z1B)

National Cancer Institute (NCI)

NCT04439201

ACTIVE NOT RECRUITING Phase 1 39 participants

Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations

National Cancer Institute (NCI)

NCT03842228

ACTIVE NOT RECRUITING Phase 2 38 participants

Testing Ado-Trastuzumab Emtansine as a Potential Targeted Treatment in Cancers With HER2 Genetic Changes (MATCH-Subprotocol Q)

National Cancer Institute (NCI)

NCT04439110

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Expression (MATCH - Subprotocol Z1H)

National Cancer Institute (NCI)

NCT06400238

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing LOXO-101 as Potentially Targeted Treatment in Cancers With NTRK Genetic Changes (MATCH - Subprotocol Z1E)

National Cancer Institute (NCI)

NCT06390852

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing AZD1775 as a Potential Targeted Treatment in Cancers With BRCA Genetic Changes (MATCH-Subprotocol Z1I)

National Cancer Institute (NCI)

NCT04439227

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing VS-6063 (Defactinib) as a Potential Targeted Treatment in Cancers With NF2 Genetic Changes (MATCH-Subprotocol U)

National Cancer Institute (NCI)

NCT04439331

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing GDC-0449 (Vismodegib) as Potentially Targeted Treatment in Cancers With Smoothened or Patched 1 Mutant Tumors (MATCH - Subprotocol T)

National Cancer Institute (NCI)

NCT06357988

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Loss of Expression (MATCH-Subprotocol P)

National Cancer Institute (NCI)

NCT04439188

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Trametinib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol R)

National Cancer Institute (NCI)

NCT04439279

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Copanlisib as a Potential Targeted Treatment in Cancers With PIK3CA Mutations (MATCH-Subprotocol Z1F)

National Cancer Institute (NCI)

NCT05490771

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Amplifications (MATCH-Subprotocol K1)

National Cancer Institute (NCI)

NCT06308822

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing AZD5363 as a Potential Targeted Treatment in Cancers With AKT Genetic Changes (MATCH-Subprotocol Y)

National Cancer Institute (NCI)

NCT04439123

ACTIVE NOT RECRUITING Phase 1 35 participants

Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or Melanoma

National Cancer Institute (NCI)

NCT01303341

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With mTOR Genetic Changes (MATCH - Subprotocol L)

National Cancer Institute (NCI)

NCT06385496

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing BVD-523FB (Ulixertinib) as Potentially Targeted Treatment in Cancers With Genetic Changes (MATCH - Subprotocol Z1L)

National Cancer Institute (NCI)

NCT06400225

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Trametinib and Dabrafenib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol H)

National Cancer Institute (NCI)

NCT04439292

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Ipatasertib as Potentially Targeted Treatment in Cancers With AKT Genetic Changes (MATCH - Subprotocol Z1K)

National Cancer Institute (NCI)

NCT06400251

ACTIVE NOT RECRUITING Phase 2 30 participants

A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer

OHSU Knight Cancer Institute

NCT06630325

ACTIVE NOT RECRUITING Phase 1 30 participants

Methoxyamine, Cisplatin, and Pemetrexed Disodium in Treating Patients With Advanced Solid Tumors or Mesothelioma That Cannot Be Removed by Surgery or Mesothelioma That Is Refractory to Pemetrexed Disodium and Cisplatin or Carboplatin

National Cancer Institute (NCI)

NCT02535312

ACTIVE NOT RECRUITING Phase 2 24 participants

Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Genetic Changes (MATCH-Subprotocol N)

National Cancer Institute (NCI)

NCT04439149

ACTIVE NOT RECRUITING Phase 1 23 participants

PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT03218826

ACTIVE NOT RECRUITING Phase 2 20 participants

Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Exon 14 Deletion Genetic Changes (MATCH - Subprotocol C2)

National Cancer Institute (NCI)

NCT06360575

ACTIVE NOT RECRUITING Phase 2 20 participants

Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)

National Cancer Institute (NCI)

NCT03698994

ACTIVE NOT RECRUITING Phase 2 20 participants

Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)

National Cancer Institute (NCI)

NCT03210714

ACTIVE NOT RECRUITING Phase 2 19 participants

Testing Afatinib as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH - Subprotocol A)

National Cancer Institute (NCI)

NCT06385483

ACTIVE NOT RECRUITING Phase 2 19 participants

Testing AZD9291 as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH-Subprotocol E)

National Cancer Institute (NCI)

NCT06303167

ACTIVE NOT RECRUITING Phase 1 15 participants

Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1

Roswell Park Cancer Institute

NCT02650986

ACTIVE NOT RECRUITING Phase 1 14 participants

Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors

National Cancer Institute (NCI)

NCT04616534

ACTIVE NOT RECRUITING Phase 1 14 participants

Dasatinib, Temsirolimus, and Cyclophosphamide in Treating Patients With Advanced, Recurrent, or Refractory Solid Tumors

M.D. Anderson Cancer Center

NCT02389309

ACTIVE NOT RECRUITING Phase 2 13 participants

Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)

National Cancer Institute (NCI)

NCT03213652

ACTIVE NOT RECRUITING Phase 1 13 participants

Testing the Sequential Combination of the Anti-cancer Drugs Olaparib Followed by Adavosertib (AZD1775) in Patients With Advanced Solid Tumors With Selected Mutations and PARP Resistance, STAR Study

National Cancer Institute (NCI)

NCT04197713

ACTIVE NOT RECRUITING Phase 2 10 participants

Testing Sunitinib as Potentially Targeted Treatment in Cancers With cKIT Genetic Changes (MATCH - Subprotocol V)

National Cancer Institute (NCI)

NCT06390826

ACTIVE NOT RECRUITING Phase 2 9 participants

Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)

National Cancer Institute (NCI)

NCT03213704

ACTIVE NOT RECRUITING Phase 1 8 participants

Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV

National Cancer Institute (NCI)

NCT04514484

ACTIVE NOT RECRUITING Phase 2 5 participants

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ALK Genetic Changes (MATCH-Subprotocol F)

National Cancer Institute (NCI)

NCT04439266

ACTIVE NOT RECRUITING Phase 2 4 participants

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ROS1 Genetic Changes (MATCH-Subprotocol G)

National Cancer Institute (NCI)

NCT04439253

ACTIVE NOT RECRUITING Phase 2 4 participants

Testing Trametinib as a Potential Targeted Treatment in Cancers With GNAQ or GNA11 Genetic Changes (MATCH-Subprotocol S2)

National Cancer Institute (NCI)

NCT04439357

COMPLETED 223 participants

Distress Associated with Coronavirus Disease 2019 and Telehealth on Supportive Care Patients with Advanced Cancer

M.D. Anderson Cancer Center

NCT05058339

COMPLETED Phase 2 208 participants

MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations

National Cancer Institute (NCI)

NCT01827384

← Previous Page 2 of 3 Next →

Phase Distribution

PhaseTrial count
Phase 1 44
Phase 2 55
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Malignant Solid Neoplasm Trial Landscape

109 indexed Advanced Malignant Solid Neoplasm studies · 27 recruiting (25%).

Phase mix: 1 late (III/IV) vs 99 early (I/II).

Top sponsor: National Cancer Institute (NCI) (67 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Malignant Solid Neoplasm?

PlainTrial tracks 109 US clinical trials for Advanced Malignant Solid Neoplasm, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Malignant Solid Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.