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NCT01827384 · ClinicalTrials.gov registry record · Phase 2
MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations
A Phase 2 study of Advanced Malignant Solid Neoplasm, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- Phase 2
- Development phase
- 208
- Enrollment target
- 8
- Study locations
NCT01827384: Completed Phase 2 study of Advanced Malignant Solid Neoplasm, sponsored by National Cancer Institute (NCI).
NCT01827384 is a Phase 2 study of Advanced Malignant Solid Neoplasm that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 208 participants, above the 175-participant average among 108 other Advanced Malignant Solid Neoplasm trials with a reported enrollment target (19% higher). The trial reports 8 study locations across 8 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01827384, a Phase 2 study of Advanced Malignant Solid Neoplasm, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 208 participants
- Enrollment target
- 8
- Study locations
Study Summary
This phase II trial studies molecular profiling-based assignment of cancer therapy (MPACT) in treating patients with solid tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced). Adavosertib, everolimus, and trametinib are drugs that each target a specific variation in tumors by blocking different proteins needed for cell growth. Veliparib blocks an enzyme that helps repair deoxyribonucleic acid (DNA) damaged by chemotherapy, which may help chemotherapy drugs work better. It is not yet known whether testing patients for variations in their tumor and assigning treatment targeting the variation is more effective than standard non-targeted therapy in treating advanced solid tumors.
Primary Outcome
ORR is the proportion of participants with a complete response (CR) or partial response (PR) per the Response Evaluation Criteria in Solid Tumors (RECIST). Complete Response is disappearance of all tumors. Partial Response is at least a 30% decrease in the sum of the diameters of target lesions, taking as reference the baseline sum of diameters.
Conditions Studied
Interventions
- DRUG Carboplatin
- DRUG Temozolomide
- DRUG Everolimus
- DRUG Trametinib
- DRUG Adavosertib
Study Locations (8)
Colorado
- University of Colorado Hospital - Aurora
Georgia
- Emory University Hospital/Winship Cancer Institute - Atlanta
Kentucky
- University of Kentucky/Markey Cancer Center - Lexington
Maryland
- National Cancer Institute Developmental Therapeutics Clinic - Bethesda
Missouri
- Washington University School of Medicine - St Louis
New Jersey
- Rutgers Cancer Institute of New Jersey - New Brunswick
Pennsylvania
- University of Pittsburgh Cancer Institute (UPCI) - Pittsburgh
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 208 participants |
| Start Date | 2014-01-07 |
| Est. Completion | 2021-10-08 |
| Phase | Phase 2 |
What the finished NCT01827384 record still lists
NCT01827384 is an interventional study that assigns participants to a tested intervention. The registered 208 participants enrollment target is mid-sized for trials with a published cap, above the 175-participant average among 108 other Advanced Malignant Solid Neoplasm trials with a reported enrollment target (19% higher).
The record links to 1 condition, with Advanced Malignant Solid Neoplasm appearing as the primary indexed condition, and to 5 interventions - of which Carboplatin is the first listed.
NCT01827384 lists 8 locations in 8 states (Colorado, Georgia, Kentucky).
Frequently Asked Questions
What is clinical trial NCT01827384 about?
NCT01827384 is a clinical study titled "MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations". This phase II trial studies molecular profiling-based assignment of cancer therapy (MPACT) in treating patients with solid tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced). Adavosertib, everolimus, and trametinib are drugs that e...
What is the current status of trial NCT01827384?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 208 participants. The study started on 2014-01-07. Estimated completion is 2021-10-08.
What conditions does trial NCT01827384 study?
This clinical trial studies the following conditions: Advanced Malignant Solid Neoplasm.
What interventions are being tested in trial NCT01827384?
The interventions under investigation include: Carboplatin (DRUG), Temozolomide (DRUG), Everolimus (DRUG), Trametinib (DRUG), Adavosertib (DRUG).
Who is sponsoring clinical trial NCT01827384?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01827384 being conducted?
This trial has 8 study locations across Colorado, Georgia, Kentucky, Maryland, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT01827384's enrollment target sits among peer trials
208 9th of 108 higher than 99 of 108 other Advanced Malignant Solid Neoplasm trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Advanced Malignant Solid Neoplasm trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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