Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07404852 · ClinicalTrials.gov registry record · NA
Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
A NA study of Acute Ischemic Stroke and Large Vessel Occlusion, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 65
- Enrollment target
- 1
- Study location
NCT07404852: Recruiting NA study of Acute Ischemic Stroke and Large Vessel Occlusion, sponsored by Washington University School of Medicine.
NCT07404852 is a NA study of Acute Ischemic Stroke and Large Vessel Occlusion that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 65 participants, below the 349-participant average among 25 other Acute Ischemic Stroke trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07404852, a NA study of Acute Ischemic Stroke and Large Vessel Occlusion, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 65 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation.
Primary Outcome
The primary endpoints of the study will include changes in the levels of brain injury biomarkers measured at onset and every 1.5 days till day 7, or discharge (whichever occurs first), this includes: Brain Derived Tau (BD-tau). The investigators will measure BD-tau in aliquots from the plasma with mononuclear antibodies that recognizes a protein of 48 to 68 kilodalton specific to BD-tau. A functional assay will be measured in picogram/milliliter. Will utilize a high sensitivity assays to minimiz
Conditions Studied
Interventions
- DEVICE transcutaneous auricular vagal nerve stimulation
- DEVICE Sham transcutaneous vagal nerve stimulation
Study Locations (1)
Missouri
- Barnes-Jewish Hospital - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 65 participants |
| Start Date | 2026-02-23 |
| Est. Completion | 2028-02-29 |
| Phase | NA |
What NCT07404852 shows while recruiting
NCT07404852 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 65 participants, a relatively small participant target, below the 349-participant average among 25 other Acute Ischemic Stroke trials with a reported enrollment target (81% lower).
The record links to 2 conditions, with Acute Ischemic Stroke appearing as the primary indexed condition, and to 2 interventions - of which transcutaneous auricular vagal nerve stimulation is the first listed.
NCT07404852 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT07404852 about?
NCT07404852 is a clinical study titled "Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke". This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted manageme...
What is the current status of trial NCT07404852?
This trial is currently recruiting. It is a NA study. The enrollment target is 65 participants. The study started on 2026-02-23. Estimated completion is 2028-02-29.
What conditions does trial NCT07404852 study?
This clinical trial studies the following conditions: Acute Ischemic Stroke, Large Vessel Occlusion.
What interventions are being tested in trial NCT07404852?
The interventions under investigation include: transcutaneous auricular vagal nerve stimulation (DEVICE), Sham transcutaneous vagal nerve stimulation (DEVICE).
Who is sponsoring clinical trial NCT07404852?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07404852 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Acute Ischemic Stroke
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07404852's enrollment target sits among peer trials
65 21st of 25 higher than 5 of 25 other Acute Ischemic Stroke trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Ischemic Stroke trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Hyperbaric Oxygen Therapy in Acute Ischemic Stroke Ischemic Stroke Recovery (Pro00061930)
RECRUITING · NA
-
The Pivotal Study of RapidPulseTM Aspiration System
RECRUITING · NA
-
An EFS to Evaluate the CGuard Prime™ Carotid Stent in Acute Ischemic Stroke
ACTIVE NOT RECRUITING · NA
-
Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI
ACTIVE NOT RECRUITING · NA
-
EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions (ESCAPE-MeVO Trial)
ACTIVE NOT RECRUITING · NA
-
Solitaire™ With the Intention For Thrombectomy as PRIMary Endovascular Treatment (SWIFT PRIME) Trial
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03366116 · 65 participants · Phase 1
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors
- NCT03603730 · 65 participants · NA
Vagal Nerve Stimulation for Functional Dyspepsia and Gastroparesis
- NCT03796559 · 65 participants · NA
Magseed Enabled Long-Term Localization of Axillary Lymph Nodes
- NCT03993106 · 65 participants · Phase 2
A Study of sEphB4-HSA in Kaposi Sarcoma
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI