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Optimizing Reperfusion to Improve Outcomes and Neurologic Function
NCT06990867 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this study is to evaluate the safety and efficacy of JX10 versus placebo in participants with Acute Ischemic Stroke (AIS) who present for care within 4.5 to 24 hours. The main question the study aims to answer are: 1. JX10 improves functional outcomes as measured by the modified Rankin Scale score when compared with placebo following AIS. 2. Risk of symptomatic intracranial hemorrhage of JX10 in participants with AIS. During Part 1, participants will be randomized to JX 10 (1mg/kg, 3 mg/kg) or placebo. During Part 2, participants will receive JX10 (optimal dose chosen from Part 1) or placebo.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG JX10
Study Locations (20)
Other
- Corxel Investigational Site — Ghent
- Corxel Investigational Site — Blagoevgrad
- Corxel Investigational Site — Burgas
California
- Corxel Investigational Site — Long Beach
- Corxel Investigational Site — Sacramento
Michigan
- Corxel Investigational Site — Kalamazoo
- Corxel Investigational Site — Traverse City
New York
- Corxel Investigational Site — Great Neck
- Corxel Investigational Site — New York
Texas
- Corxel Investigational Site — Dallas
- Corxel Investigational Site — Houston
Colorado
- Corxel Investigational Site — Colorado Springs
District of Columbia
- Corxel Investigational Site — Washington D.C.
Florida
- Corxel Investigational Site — Delray Beach
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 740 participants |
| Start Date | 2025-05-15 |
| Est. Completion | 2029-12-31 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06990867
The ClinicalTrials.gov registry entry for NCT06990867 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 740 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Corxel Pharmaceuticals, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Acute Ischemic Stroke appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06990867 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Other, California, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06990867 about?
NCT06990867 is a clinical study titled "Optimizing Reperfusion to Improve Outcomes and Neurologic Function". The goal of this study is to evaluate the safety and efficacy of JX10 versus placebo in participants with Acute Ischemic Stroke (AIS) who present for care within 4.5 to 24 hours. The main question the study aims to answer are: 1. JX10 improves functional outcomes as measured by the modified Rankin...
What is the current status of trial NCT06990867?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 740 participants. The study started on 2025-05-15. Estimated completion is 2029-12-31.
What conditions does trial NCT06990867 study?
This clinical trial studies the following conditions: Acute Ischemic Stroke. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06990867?
The interventions under investigation include: Placebo (DRUG), JX10 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06990867?
This trial is sponsored by Corxel Pharmaceuticals, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06990867 being conducted?
This trial has 20 study locations across California, Colorado, District of Columbia, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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