Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05611242 · ClinicalTrials.gov registry record · Phase 3
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
A Phase 3 study of Acute Ischemic Stroke, sponsored by Mercy Health Ohio.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 404
- Enrollment target
- 20
- Study locations
NCT05611242: Recruiting Phase 3 study of Acute Ischemic Stroke, sponsored by Mercy Health Ohio.
NCT05611242 is a Phase 3 study of Acute Ischemic Stroke that is actively recruiting participants, run by Mercy Health Ohio. The registered enrollment target is 404 participants, above the 336-participant average among 25 other Acute Ischemic Stroke trials with a reported enrollment target (20% higher). The trial reports 20 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05611242, a Phase 3 study of Acute Ischemic Stroke, is actively recruiting participants, sponsored by Mercy Health Ohio.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 404 participants
- Enrollment target
- 20
- Study locations
Study Summary
The primary objective is to establish the efficacy of intra-arterial (IA) mechanical thrombectomy (MT) with extracranial proximal carotid artery acute stenting versus non-stenting approaches in patients with acute ischemic stroke (AIS) from intracranial vessel occlusion (IVO) in the anterior circulation and have a proximal carotid occlusive disease (occlusion or severe stenosis).
Primary Outcome
Scale used for measuring the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. Scale ranges from 0-6 where 0 represents no symptoms and 6 represents death. 0 = No symptoms at all. 1. No significant disability despite symptoms; able to carry out all usual duties and activities. 2. Slight disability; unable to carry out all previous activities but able to look after own affairs without assistance. 3. Modera
Conditions Studied
Interventions
- PROCEDURE MT+CAS with IV-AP
- PROCEDURE MT+CAS with PO-AP
- PROCEDURE MT+CAT with PO-AP
Study Locations (20)
Florida
- Boca Raton - Baptist Health - Boca Raton
- Delray Medical Center - Delray Beach
- Baptist Health Research Institute - Jacksonville
- University of Florida Health Jacksonville - Jacksonville
- University of Miami School of Medicine - Miami
- Orlando Health, Inc. - Orlando
- University of South Florida - Tampa
- St. Mary's Medical Center - West Palm Beach
California
- Glendale Adventist Medical Center - Glendale
- University of California, Irvine - Irvine
- Pomona Valley - Pomona
- Sutter Institute for Medical Research - Sacramento
- California Pacific Medical Center/Mils Peninsula Medical Center - San Francisco
Illinois
- Ascension/Alexian Brothers Health System - Chicago
- University of Chicago - Chicago
- Northwestern Medicine Central DuPage Hospital - Winfield
Georgia
- Piedmont Healthcare - Atlanta
- WellStar Health System, Inc - Marietta
Alabama
- Mobile Infirmary Medical Center - Mobile
Indiana
- Indiana University Health Methodist Hospital - Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 404 participants |
| Start Date | 2024-05-08 |
| Est. Completion | 2027-05-08 |
| Phase | Phase 3 |
What NCT05611242 shows while recruiting
NCT05611242 is an interventional study that assigns participants to a tested intervention. The registered 404 participants enrollment target is mid-sized for trials with a published cap, above the 336-participant average among 25 other Acute Ischemic Stroke trials with a reported enrollment target (20% higher).
The record links to 1 condition, with Acute Ischemic Stroke appearing as the primary indexed condition, and to 3 interventions - of which MT+CAS with IV-AP is the first listed.
NCT05611242 names 20 study sites across 6 states, led by Florida, California, Illinois.
Frequently Asked Questions
What is clinical trial NCT05611242 about?
NCT05611242 is a clinical study titled "Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial". The primary objective is to establish the efficacy of intra-arterial (IA) mechanical thrombectomy (MT) with extracranial proximal carotid artery acute stenting versus non-stenting approaches in patients with acute ischemic stroke (AIS) from intracranial vessel occlusion (IVO) in the anterior circula...
What is the current status of trial NCT05611242?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 404 participants. The study started on 2024-05-08. Estimated completion is 2027-05-08.
What conditions does trial NCT05611242 study?
This clinical trial studies the following conditions: Acute Ischemic Stroke.
What interventions are being tested in trial NCT05611242?
The interventions under investigation include: MT+CAS with IV-AP (PROCEDURE), MT+CAS with PO-AP (PROCEDURE), MT+CAT with PO-AP (PROCEDURE).
Who is sponsoring clinical trial NCT05611242?
This trial is sponsored by Mercy Health Ohio, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05611242 being conducted?
This trial has 20 study locations across Alabama, California, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Acute Ischemic Stroke
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05611242's enrollment target sits among peer trials
404 10th of 25 higher than 16 of 25 other Acute Ischemic Stroke trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Ischemic Stroke trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
RECRUITING · Phase 3
-
Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial
COMPLETED · Phase 3
-
Efficacy and Safety Trial of Transcranial Laser Therapy Within 24 Hours From Stroke Onset (NEST-3)
COMPLETED · Phase 3
-
Multi-arm Optimization of Stroke Thrombolysis
COMPLETED · Phase 3
-
Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke
RECRUITING · Phase 2
-
Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT05049057 · 404 participants · Phase 2
Treatment of Acute PTH With a CGRP Receptor mAb in Military Service Members and Civilians With mTBI
- NCT06072612 · 404 participants · Phase 3
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
- NCT05576350 · 405 participants · NA
TRAC-ER Intervention to Reduce Risky Alcohol Use and HIV Risk
- NCT07066657 · 405 participants · Phase 1
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI