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NCT06225570 · ClinicalTrials.gov registry record · Early Phase 1
Weekly Isotretinoin vs Tetracycline for Moderate Acne
A Early Phase 1 study of Acne Vulgaris, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06225570: Recruiting Early Phase 1 study of Acne Vulgaris, sponsored by Medical University of South Carolina.
NCT06225570 is a Early Phase 1 study of Acne Vulgaris that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 50 participants, below the 275-participant average among 67 other Acne Vulgaris trials with a reported enrollment target (82% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06225570, a Early Phase 1 study of Acne Vulgaris, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
In the effort to find better treatments for Moderate Acne, which often relies on long-term antibiotic use, researchers are exploring alternative options. While Isotretinoin, a Vitamin A derivative, is highly effective for severe acne, its side effects limit its use for milder cases. A recent study from our institution investigated a new approach: weekly Isotretinoin dosing. The results were promising, with acne improvement and no major side effects. This suggests that weekly Isotretinoin could be a successful alternative for moderate acne in both males and females. To validate these findings, investigators propose a randomized controlled trial comparing weekly Isotretinoin to daily Doxycycline over four months. This study could confirm the safety and effectiveness of weekly Isotretinoin, as well as shed light on patient satisfaction, and long-term results compared to standard antibiotics. This research may offer a breakthrough in treating moderate acne while addressing concerns about antibiotic overuse.
Primary Outcome
Determine the efficacy of weekly isotretinoin therapy for the treatment of moderate acne vulgaris compared to the current SOC therapy, systemic tetracyclines.
Conditions Studied
Interventions
- DRUG Isotretinoin
- DRUG Tetracycline
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-02-01 |
| Est. Completion | 2026-05 |
| Phase | Early Phase 1 |
What NCT06225570 shows while recruiting
NCT06225570 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 275-participant average among 67 other Acne Vulgaris trials with a reported enrollment target (82% lower).
The record links to 1 condition, with Acne Vulgaris appearing as the primary indexed condition, and to 2 interventions - of which Isotretinoin is the first listed.
NCT06225570 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT06225570 about?
NCT06225570 is a clinical study titled "Weekly Isotretinoin vs Tetracycline for Moderate Acne". In the effort to find better treatments for Moderate Acne, which often relies on long-term antibiotic use, researchers are exploring alternative options. While Isotretinoin, a Vitamin A derivative, is highly effective for severe acne, its side effects limit its use for milder cases. A recent study f...
What is the current status of trial NCT06225570?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 50 participants. The study started on 2025-02-01. Estimated completion is 2026-05.
What conditions does trial NCT06225570 study?
This clinical trial studies the following conditions: Acne Vulgaris.
What interventions are being tested in trial NCT06225570?
The interventions under investigation include: Isotretinoin (DRUG), Tetracycline (DRUG).
Who is sponsoring clinical trial NCT06225570?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06225570 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06225570's enrollment target sits among peer trials
50 45th of 67 higher than 21 of 67 other Acne Vulgaris trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acne Vulgaris trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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