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ClinicalTrials.gov 8 recruiting now official registry

Primary Mediastinal Large B Cell Lymphoma clinical trials

8 of 12 indexed Primary Mediastinal Large B Cell Lymphoma trials are currently recruiting.

12 US clinical trials · 8 currently recruiting

Primary Mediastinal Large B Cell Lymphoma is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is University of Washington, running 2 of these trials.

The research picture

Primary Mediastinal Large B Cell Lymphoma has 12 registered US clinical trials, 8 of them open to new participants right now, about 67% of the total.

8
recruiting participants now
67%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: University of Washington
Phase 16Phase 24Phase 31

Active & Recent Trials

12 total, page 1 of 1

RECRUITING Phase 2 120 participants

Epcoritamab Compared to Observation for Treating B-cell Lymphoma Patients Not in Complete Remission After CD19-directed CAR-T Therapy

Academic and Community Cancer Research United

NCT06238648

RECRUITING Phase 1 56 participants

Polatuzumab Vedotin and Combination Chemotherapy With or Without Glofitamab for the Treatment of Untreated Aggressive Large B-cell Lymphoma

University of Washington

NCT04231877

RECRUITING 45 participants

Vaccine Responses in Patient With Multiple Myeloma and Non-Hodgkin Lymphoma After CAR-T Treatment

OHSU Knight Cancer Institute

NCT06784167

RECRUITING Phase 1 42 participants

ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies

Acepodia Biotech

NCT05653271

RECRUITING Phase 1 36 participants

Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma

C. Babis Andreadis

NCT04545762

RECRUITING Phase 2 35 participants

Pembro Plus CAR T-cell Therapy in R/R in PMBCL

Jennifer Crombie, MD

NCT05934448

RECRUITING Phase 2 28 participants

Emapalumab Prevention of CAR-T Cell Associated Toxicities

Marcela V. Maus, M.D.,Ph.D.

NCT06550141

RECRUITING Phase 2 18 participants

Epcoritamab With Dose Adjusted Etoposide, Cyclophosphamide, Vincristine, Doxorubicin, Prednisone and Rituximab (EPOCH-R) for the Treatment of Aggressive B-Cell Non-Hodgkin Lymphoma

University of Washington

NCT07097363

ACTIVE NOT RECRUITING Phase 3 244 participants

Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma

National Cancer Institute (NCI)

NCT04759586

ACTIVE NOT RECRUITING Phase 1 30 participants

19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers

Memorial Sloan Kettering Cancer Center

NCT04464200

COMPLETED Phase 1 18 participants

CLBR001 and SWI019 in Patients With Relapsed / Refractory B-cell Malignancies

Calibr, a division of Scripps Research

NCT04450069

COMPLETED Phase 1 6 participants

TC-110 T Cells in Adults With Relapsed or Refractory Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia

TCR2 Therapeutics

NCT04323657

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 4
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Primary Mediastinal Large B Cell Lymphoma Trial Landscape

12 indexed Primary Mediastinal Large B Cell Lymphoma studies · 8 recruiting (67%).

Phase mix: 1 late (III/IV) vs 10 early (I/II).

Top sponsor: University of Washington (2 trials), 9 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Primary Mediastinal Large B Cell Lymphoma?

PlainTrial tracks 12 US clinical trials for Primary Mediastinal Large B Cell Lymphoma, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Primary Mediastinal Large B Cell Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.