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RECRUITING Phase 3

A Study of Recombinant Von Willebrand Factor (rVWF) With or Without ADVATE in Children With Severe Von Willebrand Disease (VWD)

NCT02932618 · View on ClinicalTrials.gov ↗

Study Summary

The main aim of the study is to check effectiveness, side effects, and tolerability of vonicog alfa (recombinant von Willebrand factor \[rVWF\]), with or without ADVATE, in the treatment and control of nonsurgical bleeding events in pediatric participants (less than (\<)18 years of age) with severe hereditary von Willebrand disease (VWD). The participants will be treated with vonicog alfa for 12-18 months. Their von Willebrand Disease will be treated by their doctor according to their doctor's usual clinical practice. During the study, participants will be followed up at clinics or over telephone calls.

Conditions Studied

Interventions

  • BIOLOGICAL Vonicog alfa
  • BIOLOGICAL Antihemophilic Factor (Recombinant)

Study Locations (20)

Other

  • Medizinische Universität Innsbruck — Innsbruck
  • AKH - Medizinische Universität Wien — Vienna
  • UZ Leuven — Leuven
  • Fakultni nemocnice Brno — Brno

Ohio

  • Cincinnati Children's Hospital Medical Center — Cincinnati
  • Rainbow Babies and Children's Hospital — Cleveland
  • Nationwide Children's Hospital — Columbus

North Carolina

  • St. Jude Affiliate Clinic at Novant Health — Charlotte
  • Comprehensive Cancer Center of Wake Forest Unversity — Winston-Salem

Texas

  • Texas Children's Cancer and Hematology Center — Houston
  • Texas Children's Hospital — Houston

Colorado

  • University of Colorado Hemophilia & Thrombosis Center — Aurora

District of Columbia

  • Children's National Medical Center — Washington D.C.

Florida

  • University of Florida College of Medicine — Jacksonville

Illinois

  • Bleeding and Clotting Disorders Institute — Peoria

Trial Details

FieldValue
Enrollment Target 31 participants
Start Date 2017-11-06
Est. Completion 2026-03-31
Phase Phase 3

Sponsor

Baxalta now part of Shire

12 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02932618

The ClinicalTrials.gov registry entry for NCT02932618 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 31 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Baxalta now part of Shire, which has 12 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Von Willebrand Disease appearing as the primary indexed condition, and to 2 interventions — of which Vonicog alfa is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02932618 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Other, Ohio, North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02932618 about?

NCT02932618 is a clinical study titled "A Study of Recombinant Von Willebrand Factor (rVWF) With or Without ADVATE in Children With Severe Von Willebrand Disease (VWD)". The main aim of the study is to check effectiveness, side effects, and tolerability of vonicog alfa (recombinant von Willebrand factor \[rVWF\]), with or without ADVATE, in the treatment and control of nonsurgical bleeding events in pediatric participants (less than (\<)18 years of age) with severe ...

What is the current status of trial NCT02932618?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 31 participants. The study started on 2017-11-06. Estimated completion is 2026-03-31.

What conditions does trial NCT02932618 study?

This clinical trial studies the following conditions: Von Willebrand Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02932618?

The interventions under investigation include: Vonicog alfa (BIOLOGICAL), Antihemophilic Factor (Recombinant) (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02932618?

This trial is sponsored by Baxalta now part of Shire, which has 12 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02932618 being conducted?

This trial has 20 study locations across Colorado, District of Columbia, Florida, Illinois, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial