National Institute of Dental and Craniofacial Research (NIDCR)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Dental and Craniofacial Research (NIDCR) sits in the top decile of US sponsors by registered trial count (#259 of 15,742 sponsors by registered trial count).

91 total trials 11 currently recruiting 70 completed early-phase tilt top decile by trial count

National Institute of Dental and Craniofacial Research (NIDCR): 91 sponsored US clinical trials, 11 recruiting.

National Institute of Dental and Craniofacial Research (NIDCR) sponsors 91 registered US clinical trials on ClinicalTrials.gov, 11 of them currently recruiting, and 70 completed. 2 of these trials are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Sjogren's Syndrome, with 6 trials.

Top-decile sponsor footprint

National Institute of Dental and Craniofacial Research (NIDCR) ranks in the top decile of sponsors by registered trial count (#259 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 64/100

70 of 78 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (89.7%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

91 total, page 2 of 2

COMPLETED Phase 2

Rofecoxib to Prevent Pain After Third Molar (Wisdom Tooth) Extraction

NCT00026819

COMPLETED

Potential of Transplanted Stem Cells to Mature Into Salivary Gland and Cheek Cells

NCT00023491

COMPLETED Phase 3

A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome

NCT00017927

COMPLETED

Pain Evaluation and Treatment

NCT00362167

COMPLETED Phase 2

Topiramate in the Treatment of Sciatica

NCT00011804

COMPLETED Phase 2

Pain Treatment for Sciatica

NCT00009672

COMPLETED Phase 2

Capsaicin to Control Pain Following Third Molar Extraction

NCT00008476

COMPLETED

Pathophysiology of Chronic Wounds

NCT00006437

COMPLETED Phase 1

Effects of Letrozole on Precocious Puberty Due to McCune Albright Syndrome

NCT00006174

COMPLETED

Cyclooxygenase Levels Following Surgery to Remove Third Molars (Wisdom Teeth)

NCT00006175

COMPLETED Phase 2

Etanercept (Enbrel) to Treat Pain and Swelling After Third Molar Extraction

NCT00006070

COMPLETED

Oral Manifestations of Aplastic Anemia

NCT00006300

COMPLETED Phase 1

Effects of Topical SLPI on Skin Wounds

NCT00005569

COMPLETED Phase 2

Influence of Genetics in Pain Sensitivity

NCT00001956

COMPLETED

Eligibility Screening for National Institute of Dental and Craniofacial Research Studies

NCT00001983

COMPLETED Phase 2

Etanercept Therapy for Sjogren's Syndrome

NCT00001954

COMPLETED Phase 2

Celebrex for Pain Relief After Oral Surgery

NCT00006299

COMPLETED Phase 2

Study of Etanercept and Celecoxib to Treat Temporomandibular Disorders (Painful Joint Conditions)

NCT00001955

COMPLETED

The Functioning of Immune and Hormonal Systems in Patients With Sjogren's Syndrome and in Healthy Volunteers

NCT00001953

COMPLETED

Using a Narcotic to Enhance the Numbing Effect of the Local Anesthetic Lidocaine on Inflamed Molar Teeth

NCT00001952

COMPLETED

Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome

NCT00001852

COMPLETED

Bone Marrow Injection to Replace Diseased Bone in Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome

NCT00001851

COMPLETED Phase 2

Alendronate to Treat Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome

NCT00001728

COMPLETED

Study of the Composition of Dental Plaque

NCT00001726

COMPLETED Phase 2

Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain

NCT00001725

COMPLETED Phase 2

Local Flurbiprofen to Treat Pain Following Wisdom Tooth Extraction

NCT00001724

COMPLETED NA

Evaluation and Treatment of Oral Soft Tissue Diseases

NCT00001601

COMPLETED

Diagnosis and Evaluation of Patients Needing Third Molar (Wisdom Tooth) Extraction and Patients With Chronic Facial Pain

NCT00001600

COMPLETED Phase 2

Pilot Study of Thalidomide to Treat Sjogren's Syndrome

NCT00001599

COMPLETED Phase 2

DHEA Treatment for Sjogren's Syndrome

NCT00001598

COMPLETED

Pain Measurement in Healthy Volunteers

NCT00001597

COMPLETED

Studies on Abnormal Bone From Patients With Polyostotic Fibrous Dysplasia and McCune Albright Syndrome

NCT00001973

COMPLETED Phase 2

Thalidomide to Treat Oral Lesions in HIV-Infected Patients

NCT00001524

COMPLETED

Structure and Functional Status of Parotid Glands Exposed to Therapeutic Irradiation

NCT00001523

COMPLETED

Bone Regeneration Using Bone Marrow Stromal Cells

NCT00001391

COMPLETED

Salivary Evaluation in Healthy Volunteers

NCT00001390

COMPLETED Phase 2

Dextromethorphan Versus Placebo for Neuropathic Pain

NCT00001344

COMPLETED

Positron Emission Tomography to Measure Pain and Pain Control

NCT00001307

COMPLETED

Clinical Study of Oral Endosseous Titanium Implants in Edentulous Subjects

NCT00001211

TERMINATED

Evaluation of Salivary Gland Dysfunction

NCT00001196

COMPLETED NA

Evaluation of Patients With Unusual Diagnostic or Treatment Considerations

NCT00001182

← Previous Page 2 of 2

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 32
Phase 3 2

What is open in the National Institute of Dental and Craniofacial Research (NIDCR) pipeline

11 recruiting of 91 indexed (12% open); 70 completed (77%).

Phase mix: 2 late (III/IV) vs 41 early (I/II) (early-phase heavy).

Top condition: Sjogren's Syndrome (6 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Dental and Craniofacial Research (NIDCR): open-pipeline peers nationwide

Peers matched on 91 registered trials and 12% open enrollment, not the therapeutic-area sidebar.

National Institute of Dental and Craniofacial Research (NIDCR) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 20406080100 10%20%30%40%50% Total trials Recruiting share National Institute of Dental and Craniofacial Research (NIDCR)University of Central FloridaChildren's National Research InstituteDrexel UniversityLoyola UniversityEast Carolina UniversityAntonios LikourezosOregon State UniversityUniversity of Massachusetts, Amherst
National Institute of Dental and Craniofacial Research (NIDCR) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Dental and Craniofacial Research (NIDCR) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 91 trials (± recruiting share)

Sponsors near 12% open enrollment (± trial volume)

What to do with this National Institute of Dental and Craniofacial Research (NIDCR) page

91 registered trials is a research-attention snapshot, not an endorsement of National Institute of Dental and Craniofacial Research (NIDCR) or any single study.

  • 11 of National Institute of Dental and Craniofacial Research (NIDCR)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Sjogren's Syndrome is the condition National Institute of Dental and Craniofacial Research (NIDCR) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Sjogren's Syndrome trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

National Institute of Dental and Craniofacial Research (NIDCR) pipeline card: 91 registered trials from official public datasets.Report a data error.