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NCT00001307 · ClinicalTrials.gov registry record
Positron Emission Tomography to Measure Pain and Pain Control
A clinical trial, sponsored by National Institute of Dental and Craniofacial Research (NIDCR).
- Completed
- Registry status
- 273
- Enrollment target
NCT00001307: Completed study, sponsored by National Institute of Dental and Craniofacial Research (NIDCR).
NCT00001307 is a clinical trial that has completed, run by National Institute of Dental and Craniofacial Research (NIDCR). The registered enrollment target is 273 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00001307 has completed, sponsored by National Institute of Dental and Craniofacial Research (NIDCR).
- COMPLETED
- Registry status
- 273 participants
- Enrollment target
Study Summary
This study will examine how the brain processes pain signals and how the different parts of the brain work with each other in response to painful stimuli. A better understanding of how people experience pain may be helpful in developing more effective treatments. Healthy normal volunteers, patients requiring third molar (wisdom tooth) extraction, and patients with persistent pain due to disease, injury or other reason may be eligible for this study. Participants will receive one or more of the following sensory stimuli, which may cause brief discomfort or pain: * Heat/Cold - applied by an electronically controlled device that touches the skin, or by temperature-controlled water baths, or by a thermally controlled brass cylinder the subject grasps * Capsaicin (active ingredient in hot chili peppers) - injected in a small volume of fluid under the skin or into a muscle * Mechanical stimulation - brushings or vibrations that do not normally cause pain * Ischemic stimulation - inflation of a blood pressure cuff on the arm or leg for up to 30 minutes These stimuli will be applied both before and during positron emission tomography (PET) scanning. This test shows which parts of the brain are active and which are not and is important for studying how different parts of the brain work together to feel and react to specific sensations. For this procedure, the subject lies on a table in the PET scanner while a series of scans are taken during different sensory conditions. At the beginning of each scan, radioactive water is injected into an arm vein through a catheter (a thin plastic tube). A special camera records the arrival and disappearance of the radiation in various brain areas, creating a picture of the brain's activity in various regions. Oral surgery patients may have PET scans both before and after their wisdom tooth extraction. Alfentanil, a commonly used narcotic pain reliever, will also be given during the PET procedure to determine how the brain responds to s
Interventions
- DRUG Capsaicin
- DRUG Oxygen-15 Water
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 273 participants |
| Start Date | 1992-08 |
| Est. Completion | 2005-08 |
What the finished NCT00001307 record still lists
NCT00001307 is an observational study that tracks outcomes without assigning an intervention. The registered 273 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 2 interventions - of which Capsaicin is the first listed.
NCT00001307 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00001307 about?
NCT00001307 is a clinical study titled "Positron Emission Tomography to Measure Pain and Pain Control". This study will examine how the brain processes pain signals and how the different parts of the brain work with each other in response to painful stimuli. A better understanding of how people experience pain may be helpful in developing more effective treatments. Healthy normal volunteers, patients...
What is the current status of trial NCT00001307?
This trial is currently completed. The enrollment target is 273 participants. The study started on 1992-08. Estimated completion is 2005-08.
What interventions are being tested in trial NCT00001307?
The interventions under investigation include: Capsaicin (DRUG), Oxygen-15 Water (DRUG).
Who is sponsoring clinical trial NCT00001307?
This trial is sponsored by National Institute of Dental and Craniofacial Research (NIDCR), which has 91 total clinical trials registered on ClinicalTrials.gov.
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