Duke University

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Duke University sits in the top decile of US sponsors by registered trial count (#9 of 15,742 sponsors by registered trial count).

1,725 total trials 187 currently recruiting 1244 completed early-phase tilt top decile by trial count

Duke University: 1,725 sponsored US clinical trials, 187 recruiting.

Duke University sponsors 1,725 registered US clinical trials on ClinicalTrials.gov, 187 of them currently recruiting, and 1,244 completed. 175 of these trials are in Phase 3-4 (later-stage) and 311 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 15 trials.

Top-decile sponsor footprint

Duke University ranks in the top decile of sponsors by registered trial count (#9 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 55/100

1,244 of 1,444 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (86.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,725 total, page 14 of 35

TERMINATED NA

iControl Chronic Kidney Disease

NCT03951363

COMPLETED NA

Promoting Breast Cancer Screening in Women Who Survived Childhood Cancer

NCT03435380

COMPLETED NA

A Research Program Targeting Pre- and Peri-transplant Optimization Program (R-PPOP)

NCT03823651

COMPLETED

Harnessing Sleep/Circadian Rhythm Data as a Biomarker to Mitigate Health Risks

NCT03843762

COMPLETED NA

Implementation Program to Improve CHG Bathing Compliance

NCT03898115

COMPLETED Phase 4

ED90 for Hyperbaric Bupivacaine in Super Obese Parturients

NCT03781388

COMPLETED

ClinRO Sedation Validation

NCT03956342

COMPLETED NA

Mindfulness Meditation in Glioma Patients

NCT03915912

COMPLETED NA

Addressing Palliative Care Needs Among Intensive Care Unit Family Members

NCT03506438

COMPLETED Phase 2

Trial of Rifaximin in Probable Alzheimer's Disease

NCT03856359

COMPLETED

Understanding and Improving Anticoagulation Dosing for Patients With Atrial Fibrillation

NCT03719144

COMPLETED NA

Impact of Reduced Cannabis Use on Functional Outcomes

NCT03681353

COMPLETED NA

Heated Humidified Breathing Circuit Rewarming in Hypothermic Post Cardiopulmonary Bypass Patients.

NCT03697122

COMPLETED NA

A Trial Assessing the Safety and Feasibility of Respiratory Muscle Training and Exercise Training in Children and Adolescents With Persistent Asthma

NCT03911206

COMPLETED NA

DeStress for Health: Partnering With Granville and Vance Counties to Reduce Stress and Cancer Risk

NCT03776890

COMPLETED Phase 4

ED90 of 3% Chloroprocaine for Cervical Cerclage

NCT03805438

COMPLETED NA

Emotion Regulation and Emotion Perception

NCT03790878

TERMINATED Phase 2

Seizure Prophylaxis in Patients With Glioma or Brain Metastasis

NCT03436433

COMPLETED NA

Walking Gait Biomechanics Following Knee Joint Effusion

NCT03805464

COMPLETED NA

Using Neuroscience to Optimize Digital Health Interventions Across Adulthood

NCT03744052

COMPLETED Phase 4

Adenosine Contrast CorrELations in Evaluating RevAscularizaTION

NCT03557385

COMPLETED Phase 4

Genicular Nerve Block for Total Knee Arthroplasty

NCT03706313

TERMINATED NA

Blood Flow Restriction Concussion

NCT03695042

TERMINATED Phase 4

Desipramine in Infantile Neuroaxonal Dystrophy (INAD).

NCT03726996

COMPLETED NA

A Survivorship Care Plan and Embedded Navigation Tool

NCT03424837

COMPLETED

Long-term Antipsychotic Pediatric Safety Trial

NCT03522168

COMPLETED

SDH of HPV Vaccine Completion

NCT03709602

COMPLETED NA

Peer Support Dyads in Churches

NCT03463941

COMPLETED

IMPROVE Stroke Care- Developing and Optimizing Regional Systems of Stroke Care

NCT04242784

TERMINATED Phase 2

Impact of Combined Medication and Behavioral Treatment for ASD & ADHD

NCT03242772

COMPLETED

A 24 Month Observational Study of Infants 3-24 Months, Who Suffer an Acute Episode of Respiratory Infection and Wheezing Illness

NCT03741322

COMPLETED

Study of Pediatric Migraine: The Pediatric Migraine Registry

NCT03742024

COMPLETED Phase 4

Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)

NCT03726268

COMPLETED NA

Contribution of Urethral Sensory Feedback in Voiding Efficiency

NCT03637582

COMPLETED NA

Acute Exercise Effects in Obese Pregnancy

NCT03750695

TERMINATED NA

INTERVAL: Ipilimumab and Nivolumab Combination Therapy: A Study of a Supervised or Semi-Supervised Exercise InteRVention or Usual Care With Functional Capacity and Quality of Life Evaluations in Subjects With Advanced or Metastatic RenAL Cell Carcinoma

NCT03692338

COMPLETED

Association Between Activity and PROMIS Pediatric Measures in Children With Asthma

NCT03933540

COMPLETED NA

OCT Technology Development to Assess Ocular Integrity and Characterize Ocular Integrity and Intraocular Scatterers

NCT03531853

COMPLETED NA

Coherence Imaging of the Cervical Epithelium With Scanning a/LCI

NCT03502798

COMPLETED

Disseminating NIH Evidence Based Sickle Cell Recommendations in North Carolina

NCT03253211

COMPLETED NA

Implementation and Evaluations of Sepsis Watch

NCT03655626

COMPLETED NA

Testing a Neurocognitive Model of Distancing Using Transcranial Magnetic Stimulation.

NCT03698591

COMPLETED NA

Digital Supportive Care Awareness & Navigation

NCT03628794

COMPLETED NA

Calming Alternatives Learned During MRI-Guided Breast Biopsy

NCT03877146

COMPLETED NA

Reactions to Warnings on Hookah Ads

NCT03723616

COMPLETED Phase 2

Phase II Multicenter Study of Durvalumab and Olaparib in Platinum tReated Advanced Triple Negative Breast Cancer (DORA)

NCT03167619

COMPLETED NA

Communication Coaching to Improve Patient and Clinician Satisfaction in Cardiology Encounters

NCT03464110

COMPLETED NA

Extra Layer Of Support

NCT03532997

COMPLETED

Study of ALS Reversals 4: LifeTime Exposures

NCT03706391

COMPLETED NA

OCT Pilot in Esophagus

NCT03434834

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Phase Distribution

PhaseTrial count
Phase 1 136
Phase 2 175
Phase 3 41
Phase 4 134

What is open in the Duke University pipeline

187 recruiting of 1,725 indexed (11% open); 1,244 completed (72%).

Phase mix: 175 late (III/IV) vs 311 early (I/II) (early-phase heavy).

Top condition: Obesity (15 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Duke University: open-pipeline peers nationwide

Peers matched on 1,725 registered trials and 11% open enrollment, not the therapeutic-area sidebar.

Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 5%10%15%20% Total trials Recruiting share Duke UniversityUniversity of California, San FranciscoStanford UniversityVA Office of Research and DevelopmentPfizerCarnegie Mellon UniversityCAMC Health SystemUConn HealthHartford Hospital
Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,725 trials (± recruiting share)

Sponsors near 11% open enrollment (± trial volume)

What to do with this Duke University page

1,725 registered trials is a research-attention snapshot, not an endorsement of Duke University or any single study.

  • 187 of Duke University's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition Duke University studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Duke University pipeline card: 1,725 registered trials from official public datasets.Report a data error.