Disc Medicine

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Disc Medicine sits in the top decile of US sponsors by registered trial count (#1,458 of 15,742 sponsors by registered trial count).

9 total trials 5 currently recruiting 3 completed early-phase tilt top decile by trial count

Disc Medicine: 9 sponsored US clinical trials, 5 recruiting.

Disc Medicine sponsors 9 registered US clinical trials on ClinicalTrials.gov, 5 of them currently recruiting, and 3 completed. 1 of these trials are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Anemia, with 2 trials.

Top-decile sponsor footprint

Disc Medicine ranks in the top decile of sponsors by registered trial count (#1,458 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Open and recent trials

9 total, page 1 of 1

RECRUITING Phase 2

Study of DISC-0974-201 in Participants With IBD and Anemia

NCT07368972
RECRUITING Phase 1

A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

NCT07187973
RECRUITING Phase 2

A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)

NCT06985147
RECRUITING Phase 3

Study of Bitopertin in Participants With EPP or XLP (APOLLO)

NCT06910358
RECRUITING Phase 1

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

NCT05320198
ACTIVE NOT RECRUITING Phase 1

Study of DISC-0974 to Assess the Safety, Tolerability, PK and PD of DISC-0974 in Participants With CKD and Anemia

NCT05745883
COMPLETED Phase 1

A Study of DISC-3405 in Healthy Volunteers

NCT06050915
COMPLETED Phase 2

Study of Bitopertin to Evaluate the Safety, Tolerability, Efficacy, and PPIX Concentrations in Participants With EPP

NCT05308472
COMPLETED Phase 1

Study to Evaluate the Safety, Tolerability, PK and PD of DISC-0974 in Healthy Subjects

NCT04999527

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 3
Phase 3 1

Therapeutic Areas

Anemia 2
Anemia of Chronic Kidney Disease 1
Polycythemia Vera (PV) 1
X-Linked Protoporphyria (XLP) 1
Erythropoietic Protoporphyria (EPP) 1
Myelofibrosis Due to and Following Polycythemia Vera 1
Myelofibrosis; Anemia 1
Inflammatory Bowel Disease (IBD); Anemia 1
Post-Essential Thrombocythemia Myelofibrosis 1
Myelofibrosis 1

What is open in the Disc Medicine pipeline

5 recruiting of 9 indexed (56% open); 3 completed (33%).

Phase mix: 1 late (III/IV) vs 8 early (I/II) (early-phase heavy).

Top condition: Anemia (2 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Disc Medicine: open-pipeline peers nationwide

Peers matched on 9 registered trials and 56% open enrollment, not the therapeutic-area sidebar.

Disc Medicine sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 81012141618 0%20%40%60% Total trials Recruiting share Disc Medicine4D Molecular Therapeutics9 Meters BiopharmaAadi BioscienceAblynx, a Sanofi companyHeart Rhythm Clinical and Research SolutionsJoseph TuscanoReplimuneMGH Institute of Health Professions
Disc Medicine sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Disc Medicine sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 9 trials (± recruiting share)

Sponsors near 56% open enrollment (± trial volume)

Related

Read our methodology - how this data is sourced, computed, and verified.

What to do with this Disc Medicine page

9 registered trials is a research-attention snapshot, not an endorsement of Disc Medicine or any single study.

  • 5 of Disc Medicine's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Anemia is the condition Disc Medicine studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Anemia trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Disc Medicine pipeline card: 9 registered trials from official public datasets.Report a data error.