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ClinicalTrials.gov 6 recruiting now official registry

Post-Essential Thrombocythemia Myelofibrosis clinical trials

6 of 10 indexed Post-Essential Thrombocythemia Myelofibrosis trials are currently recruiting.

10 US clinical trials · 6 currently recruiting

Post-Essential Thrombocythemia Myelofibrosis is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is John Mascarenhas, running 2 of these trials.

The research picture

Post-Essential Thrombocythemia Myelofibrosis has 10 registered US clinical trials, 6 of them open to new participants right now, about 60% of the total.

6
recruiting participants now
60%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
2
top sponsor: John Mascarenhas
Phase 16Phase 21Phase 33

Active & Recent Trials

10 total, page 1 of 1

RECRUITING Phase 3 400 participants

A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

Merck Sharp & Dohme

NCT06351631

RECRUITING Phase 3 399 participants

A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

Swedish Orphan Biovitrum

NCT03165734

RECRUITING Phase 1 150 participants

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

Disc Medicine

NCT05320198

RECRUITING Phase 1 76 participants

A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)

Ajax Therapeutics

NCT06343805

RECRUITING Phase 1 24 participants

Pacritinib w/ Talazoparib in Pts w/ Myeloproliferative Neoplasms Unresponsive to JAK2 Inhibition

Fox Chase Cancer Center

NCT06218628

RECRUITING Phase 2 14 participants

Study of Canakinumab in Patients With Myelofibrosis

John Mascarenhas

NCT05467800

ACTIVE NOT RECRUITING Phase 3 430 participants

Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)

Novartis Pharmaceuticals

NCT04603495

ACTIVE NOT RECRUITING Phase 1 84 participants

INCB000928 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Anemia Due to Myeloproliferative Disorders

Incyte Corporation

NCT04455841

COMPLETED Phase 1 77 participants

Safety and Tolerability Study of Oral NS-018 in Patients With Primary Myelofibrosis (MF), Post-polycythemia Vera MF or Post-essential Thrombocythemia MF

NS Pharma

NCT01423851

COMPLETED Phase 1 21 participants

MPN-RC 118 AVID200 in Myelofibrosis

John Mascarenhas

NCT03895112

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 1
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Post-Essential Thrombocythemia Myelofibrosis Trial Landscape

10 indexed Post-Essential Thrombocythemia Myelofibrosis studies · 6 recruiting (60%).

Phase mix: 3 late (III/IV) vs 7 early (I/II).

Top sponsor: John Mascarenhas (2 trials), 8 others listed. 10 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Post-Essential Thrombocythemia Myelofibrosis?

PlainTrial tracks 10 US clinical trials for Post-Essential Thrombocythemia Myelofibrosis, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Post-Essential Thrombocythemia Myelofibrosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.