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NCT06985147 · ClinicalTrials.gov registry record · Phase 2
A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)
A Phase 2 study of Polycythemia Vera (PV), sponsored by Disc Medicine.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 14
- Study locations
NCT06985147 is a Phase 2 study of Polycythemia Vera (PV) that is actively recruiting participants, run by Disc Medicine. The registered enrollment target is 60 participants. The trial reports 14 study locations across 10 states.
The verdict
NCT06985147, a Phase 2 study of Polycythemia Vera (PV), is actively recruiting participants, sponsored by Disc Medicine.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 14
- Study locations
Study Summary
This open-label, multicenter, within-participant dose escalation study examining up to 2 dose levels of DISC-3405 will assess the safety, tolerability, efficacy, pharmacokinetics, and pharmacodynamics of DISC-3405 in participants with polycythemia vera (PV).
Conditions Studied
Interventions
- DRUG DISC-3405
Study Locations (14)
California
- USC Norris Comprehensive Cancer Center - Los Angeles
- UCLA Health - Los Angeles
- Keck Medicine of USC - Cancer Clinic- Newport Beach - Newport Beach
North Carolina
- Atrium Health - Levine Cancer Center - Charlotte
- Duke University - Durham
- Atrium Health Wake Forest Baptist Medical Center - Winston-Salem
Arizona
- Mayo Clinic in Arizona - Phoenix
Florida
- Mayo Clinic in Florida - Jacksonville
Minnesota
- Mayo Clinic in Minnesota - Rochester
Missouri
- Siteman Cancer Center - Washington University St. Louis - St Louis
Ohio
- Ohio State University - Columbus
Oregon
- Oregon Health & Science University - Portland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-08-12 |
| Est. Completion | 2029-02 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06985147
The ClinicalTrials.gov registry entry for NCT06985147 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Disc Medicine, which has 9 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Polycythemia Vera (PV) appearing as the primary indexed condition, and to 1 intervention - of which DISC-3405 is the first listed.
NCT06985147 reports 14 study locations spanning 10 distinct geographic areas - top geographies include California, North Carolina, Arizona.
Frequently Asked Questions
What is clinical trial NCT06985147 about?
NCT06985147 is a clinical study titled "A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)". This open-label, multicenter, within-participant dose escalation study examining up to 2 dose levels of DISC-3405 will assess the safety, tolerability, efficacy, pharmacokinetics, and pharmacodynamics of DISC-3405 in participants with polycythemia vera (PV).
What is the current status of trial NCT06985147?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2025-08-12. Estimated completion is 2029-02.
What conditions does trial NCT06985147 study?
This clinical trial studies the following conditions: Polycythemia Vera (PV).
What interventions are being tested in trial NCT06985147?
The interventions under investigation include: DISC-3405 (DRUG).
Who is sponsoring clinical trial NCT06985147?
This trial is sponsored by Disc Medicine, which has 9 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06985147 being conducted?
This trial has 14 study locations across Arizona, California, Florida, Minnesota, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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