Blueprint Medicines Corporation
Blueprint Medicines Corporation sponsors 24 registered US clinical trials on ClinicalTrials.gov, 6 of them currently recruiting, and 12 completed. 1 of these trials are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is KIT D816V Mutation, with 2 trials.
Trial Pipeline
24 total, page 1 of 1
A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations
NCT07629960
An Observational Study in Participants With Indolent Systemic Mastocytosis (ISM)
NCT07264959
A Study of Elenestinib in Healthy Adult Female Participants
NCT07388511
Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations
NCT07143669
Study of BLU-808 in Chronic Inducible Urticaria (CIndU) and Chronic Spontaneous Urticaria (CSU)
NCT06931405
(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis
NCT04910685
(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis
NCT03731260
Study of BLU-808 in Healthy Adult Participants
NCT06948032
Study of Elenestinib (BLU-263) in Advanced Systemic Mastocytosis (AdvSM) and and Other KIT Altered Hematologic Malignancies
NCT05609942
A Drug-drug Interaction Study of Avapritinib and Midazolam
NCT04908176
(VELA) Study of BLU-222 in Advanced Solid Tumors
NCT05252416
(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations
NCT05241873
A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling
NCT04773782
(HARMONY) Study of BLU-701 in EGFR-mutant NSCLC
NCT05153408
(PROSPECTOR) Screening Study Evaluating the Prevalence of the KIT D816V Mutation in Patients With Systemic Mast Cell Activation
NCT04811365
(SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC
NCT04862780
Retrospective Study Assessing the Effect of Avapritinib Versus Best Available Therapy in Patients With AdvSM
NCT04695431
Safety, Tolerability, Pharmacokinetics, and Food Effect of BLU-782 in Healthy Adults
NCT03858075
(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis
NCT03580655
(VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST
NCT03465722
(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies
NCT02561988
Mast Cell Connect: A Registry for Patients With Mastocytosis
NCT02620254
(NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors
NCT02508532
A Phase 1 Study of Fisogatinib (BLU-554) in Patients With Hepatocellular Carcinoma
NCT02508467
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 14 |
| Phase 2 | 4 |
| Phase 3 | 1 |
Therapeutic Areas
What the Pipeline for Blueprint Medicines Corporation Shows
According to the ClinicalTrials.gov registry, Blueprint Medicines Corporation is linked to 24 US clinical trials across every stage of research activity. Of those, 6 studies are currently recruiting, about 25% of the sponsor's indexed portfolio, and 12 are already marked complete, representing roughly 50% of the total.
The phase mix for Blueprint Medicines Corporation reports 1 late-stage studies (Phase 3 and Phase 4 combined) and 18 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Blueprint Medicines Corporation is KIT D816V Mutation with 2 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.