Blueprint Medicines Corporation

24 total trials 6 currently recruiting 12 completed

Blueprint Medicines Corporation sponsors 24 registered US clinical trials on ClinicalTrials.gov, 6 of them currently recruiting, and 12 completed. 1 of these trials are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is KIT D816V Mutation, with 2 trials.

Trial Pipeline

24 total, page 1 of 1

RECRUITING Phase 1

A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

NCT07629960

RECRUITING

An Observational Study in Participants With Indolent Systemic Mastocytosis (ISM)

NCT07264959

RECRUITING Phase 1

A Study of Elenestinib in Healthy Adult Female Participants

NCT07388511

RECRUITING

Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations

NCT07143669

RECRUITING Phase 2

Study of BLU-808 in Chronic Inducible Urticaria (CIndU) and Chronic Spontaneous Urticaria (CSU)

NCT06931405

RECRUITING Phase 2

(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

NCT04910685

ACTIVE NOT RECRUITING Phase 2

(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis

NCT03731260

COMPLETED Phase 1

Study of BLU-808 in Healthy Adult Participants

NCT06948032

TERMINATED Phase 1

Study of Elenestinib (BLU-263) in Advanced Systemic Mastocytosis (AdvSM) and and Other KIT Altered Hematologic Malignancies

NCT05609942

COMPLETED Phase 1

A Drug-drug Interaction Study of Avapritinib and Midazolam

NCT04908176

TERMINATED Phase 1

(VELA) Study of BLU-222 in Advanced Solid Tumors

NCT05252416

TERMINATED Phase 1

(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations

NCT05241873

COMPLETED Phase 1

A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling

NCT04773782

TERMINATED Phase 1

(HARMONY) Study of BLU-701 in EGFR-mutant NSCLC

NCT05153408

COMPLETED

(PROSPECTOR) Screening Study Evaluating the Prevalence of the KIT D816V Mutation in Patients With Systemic Mast Cell Activation

NCT04811365

TERMINATED Phase 1

(SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC

NCT04862780

COMPLETED

Retrospective Study Assessing the Effect of Avapritinib Versus Best Available Therapy in Patients With AdvSM

NCT04695431

COMPLETED Phase 1

Safety, Tolerability, Pharmacokinetics, and Food Effect of BLU-782 in Healthy Adults

NCT03858075

COMPLETED Phase 2

(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis

NCT03580655

COMPLETED Phase 3

(VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST

NCT03465722

COMPLETED Phase 1

(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies

NCT02561988

COMPLETED

Mast Cell Connect: A Registry for Patients With Mastocytosis

NCT02620254

COMPLETED Phase 1

(NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors

NCT02508532

COMPLETED Phase 1

A Phase 1 Study of Fisogatinib (BLU-554) in Patients With Hepatocellular Carcinoma

NCT02508467

What the Pipeline for Blueprint Medicines Corporation Shows

According to the ClinicalTrials.gov registry, Blueprint Medicines Corporation is linked to 24 US clinical trials across every stage of research activity. Of those, 6 studies are currently recruiting, about 25% of the sponsor's indexed portfolio, and 12 are already marked complete, representing roughly 50% of the total.

The phase mix for Blueprint Medicines Corporation reports 1 late-stage studies (Phase 3 and Phase 4 combined) and 18 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Blueprint Medicines Corporation is KIT D816V Mutation with 2 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.