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Treatment-Resistant Depression: early-phase trial registry
20 of 55 indexed Treatment-Resistant Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #254 of 28,707 conditions by registered trial count.
55 US clinical trials · 20 currently recruiting · #254 of 28,707 conditions by registered trial count
Treatment-Resistant Depression: 55 US clinical trials tracked, 20 recruiting.
Treatment-Resistant Depression is the subject of 55 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 5 of these trials.
Enrollment posture brief
Registry condition treatment-resistant-depression
OPEN 20 | RECR 36% | LATE 7 | EARLY 19 | RANK #254 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Acquired Brain Injury (36% recruiting · 11 trials)
Treatment-Resistant Depression lists 20 open slots (36% of 55 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Treatment-Resistant Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Treatment-Resistant Depression is recruiting below its size-band peers.
20 of 55 indexed trials (36.4%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Treatment-Resistant Depression trials is spread across many organizations.
Washington University School of Medicine accounts for 5 of 55 trials (9.1%). 38 distinct sponsors appear on at least one study for this condition label.
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Most Treatment-Resistant Depression trials plan to enrol fewer than 100 people.
Median target enrolment is 50 among the 55 trials that report a genuine target (sentinel values excluded). 37 of those (67.3%) plan for fewer than 100 participants.
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Treatment-Resistant Depression research is mostly interventional.
51 interventional and 4 observational studies make up this index (92.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
55 total, page 2 of 2
Mechanistic Evaluation of Response in TRD (MERIT)
Axsome Therapeutics
NCT04608396
Multiple Ascending Dose Phase 1 Study of ALA-3000
Alar Pharmaceuticals
NCT06965569
Neuroimaging in Patients Undergoing TMS for Depression
New York State Psychiatric Institute
NCT02974296
Pilot Accelerated Theta Burst in Treatment-Resistant Bipolar Depression
Stanford University
NCT03953417
Dose-Optimized and Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression
University of California, San Diego
NCT06730841
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 13 |
| Phase 3 | 6 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Treatment-Resistant Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Treatment-Resistant Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Treatment-Resistant Depression page
55 registered trials, 20 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 20 Treatment-Resistant Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Washington University School of Medicine sponsors the most Treatment-Resistant Depression trials on record, review their full trial history before evaluating a specific study. See Washington University School of Medicine's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Treatment-Resistant Depression condition card totals 55 registered trials; most-linked intervention Psilocybin; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.