Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Tobacco Smoking
Open-data reference.
39 US clinical trials · 15 currently recruiting
Active & Recent Trials
The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study
Memorial Sloan Kettering Cancer Center
NCT06535867
CONNECT Cancer Survivors With Tobacco Treatment
Washington University School of Medicine
NCT07020273
Reach Through Equitable Implementation in Utah
University of Utah
NCT06881069
Smoking Cessation Program in the Construction Sector
University of Miami
NCT06098144
Smoke-free Home Study in Subsidized Housing
University of California, San Francis
NCT06170437
Intervention to Increase Intention to Change Alcohol/Tobacco Use in Veterans With Chronic Disease
VA Office of Research and Development
NCT07039175
Cannabidiol for Reducing Cigarette Use
University of California, Los Angeles
NCT06218056
Development of a Smoking Cessation Video Series
Wayne State University
NCT06443294
Using Novel Behavioral Economic Measures to Characterize Dual Marijuana and Tobacco Use in Young Adults
Brown University
NCT07398443
Effects of Cannabidiol on Stress and Nicotine Withdrawal
Johns Hopkins University
NCT07001930
Oral Cannabidiol for Tobacco Cessation
Johns Hopkins University
NCT05445804
Abuse Liability for Five Modern Oral Nicotine Products
RAI Services Company
NCT07132814
Trauma-Informed Care for Smoking Cessation for Pregnancy
University of California, San Francis
NCT07129590
Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates
Corporal Michael J. Crescenz VA Medical Center
NCT03495024
A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
Memorial Sloan Kettering Cancer Center
NCT06693700
Potential Impact of Menthol Ban in Cigarettes and E-cigarettes
Yale University
NCT05259566
The Effect of Tobacco Products on Wound Healing
University of Minnesota
NCT04870970
Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers
University of Colorado, Denver
NCT03347838
Helping Poor Smokers Quit
Washington University School of Medicine
NCT03194958
Evaluation of the Media Detective Program for Elementary School-Aged Children to Prevention Substance Use
Innovation Research & Training
NCT01060852
Methods Project 4: Clinical Trial - Amended
University of Minnesota
NCT03111537
CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Ambulatory Setting
RAI Services Company
NCT05307822
A Facebook Intervention for Young Sexual and Gender Minority Smokers
University of California, San Francis
NCT03259360
Innovative Digital Therapeutic for Smoking Cessation
My Digital Study
NCT03694327
A Guided Imagery Tobacco Cessation Intervention Delivered by a Quit Line and Website
University of Arizona
NCT02968381
Developing Genetic Education for Smoking Cessation
University of Nebraska
NCT01186016
Recruitment Messages for Current Smokers Recently Diagnosed With Cancer
University of Oklahoma
NCT05471284
Promoting Evidenced-Based Tobacco Smoking Cessation Treatment in Community Mental Health Clinics
Johns Hopkins University
NCT04796961
CSD200907: A Study to Assess Elements of Abuse Liability for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants
RAI Services Company
NCT05114863
Connecting Alaska Native People to Quit Smoking
Mayo Clinic
NCT03645941
Tobacco and Socioeconomic Disadvantage
Rutgers, The State University of New Jersey
NCT03620708
CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches
RAI Services Company
NCT05294497
Effects of Nature Exposure on Smoking Behavior
University of Montana
NCT03716440
Acute Effects of TCIG vs ECIG in PLWH
University of California, Los Angeles
NCT04568395
A Study to Assess the Pharmacokinetics of Oral Nicotine Pouches and Lozenges in Healthy Adults
British American Tobacco (Investments) Limited
NCT04755348
Pilot Testing a Computer Delivered Tobacco Cessation Intervention in Outpatient Clinical Settings: A Feasibility Study
Johns Hopkins University
NCT05145738
Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes
University of California, San Francis
NCT04053868
Brain Imaging in Tobacco Smokers During a Quit Attempt
Johns Hopkins University
NCT04055467
E-cigarettes to Promote Smoking Reduction Among Individuals With Schizophrenia
The University of Texas Health Science Center, Houston
NCT02918630
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 3 |
| Phase 2 | 2 |
| Phase 3 | 1 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Tobacco Smoking Trial Landscape
ClinicalTrials.gov lists 39 US studies indexed under Tobacco Smoking, and 15 of those are currently open to recruitment — roughly 38% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Tobacco Smoking shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Tobacco Smoking is led by Johns Hopkins University with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 39 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Tobacco Smoking?
PlainTrial tracks 39 US clinical trials for Tobacco Smoking, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Tobacco Smoking?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.