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2026 data Public-data reference. official source

TNBC - Triple-Negative Breast Cancer

Open-data reference.

20 US clinical trials · 15 currently recruiting

Active & Recent Trials

RECRUITING Phase 2 5,000 participants

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

QuantumLeap Healthcare Collaborative

NCT01042379

RECRUITING 900 participants

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

Tempus AI

NCT07211178

RECRUITING Phase 1 430 participants

Study of AVZO-021 in Patients With Advanced Solid Tumors

Avenzo Therapeutics

NCT05867251

RECRUITING 422 participants

CtDNA Based MRD Testing for NAC Monitoring in TNBC

Personalis

NCT06230185

RECRUITING 300 participants

Role of the Immune Environment in Response to Therapy in Breast Cancer

Abramson Cancer Center at Penn Medicine

NCT05396612

RECRUITING Phase 1 260 participants

BAL0891 in Patients With Advanced Solid Tumors or Relapsed or Refractory Acute Myeloid Leukemia

SillaJen

NCT05768932

RECRUITING Phase 1 258 participants

A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors

BeiGene

NCT06257264

RECRUITING Phase 1 250 participants

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

Tubulis

NCT06657222

RECRUITING Phase 1 175 participants

Study of LP-184 in Patients With Advanced Solid Tumors

Lantern Pharma

NCT05933265

RECRUITING Phase 2 90 participants

A Phase 2 Study of PCS6422 With Capecitabine in Patients With Advanced or Metastatic Breast Cancer

Processa Pharmaceuticals

NCT06568692

RECRUITING Phase 2 36 participants

Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC)

The Methodist Hospital Research Institute

NCT05660083

RECRUITING Phase 2 34 participants

Phase II Trial of Ivonescimab in Combination With Carboplatin + Docetaxel in Patients With Early-Stage Triple Negative Breast Cancer

Cedars-Sinai Medical Center

NCT07017673

RECRUITING Phase 2 34 participants

A Study of Radiation Therapy With Pembrolizumab and Olaparib or Other Radiosensitizers in Women Who Have Triple-Negative or Hormone-Receptor Positive/Her2 Negative Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT04683679

RECRUITING Early Phase 1 15 participants

Neoadjuvant Dupilumab, Pembrolizumab, Paclitaxel, and Carboplatin in Locally Advanced Triple Negative Breast Cancer

Rima Patel

NCT06637306

RECRUITING NA 15 participants

NearWave Optical Molecular Monitoring

Indiana University

NCT06744465

ACTIVE NOT RECRUITING Phase 2 107 participants

Randomized Study of Stereotactic Body Radiation Therapy (SBRT) in Patients With Oligoprogressive Metastatic Cancers of the Breast and Lung

Memorial Sloan Kettering Cancer Center

NCT03808662

ACTIVE NOT RECRUITING Phase 1 70 participants

TH1902 in Patients With Advanced Solid Tumors

Theratechnologies

NCT04706962

ACTIVE NOT RECRUITING Phase 1 37 participants

Gedatolisib Plus Talazoparib in Advanced Triple Negative or BRCA1/2 Positive, HER2 Negative Breast Cancers

Kari Wisinski

NCT03911973

ACTIVE NOT RECRUITING Early Phase 1 35 participants

Adjuvant Therapy With an Alpha-lactalbumin Vaccine in Triple-Negative Breast Cancer

George T. Budd

NCT04674306

ACTIVE NOT RECRUITING Phase 2 35 participants

Reinvigorating TNBC Response to Immunotherapy With Combination Myeloid Inhibition and Radiation

Stephen Shiao

NCT05491226

Phase Distribution

PhaseTrial count
Early Phase 1 9
Phase 2 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the TNBC - Triple-Negative Breast Cancer Trial Landscape

ClinicalTrials.gov lists 20 US studies indexed under TNBC - Triple-Negative Breast Cancer, and 15 of those are currently open to recruitment — roughly 75% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for TNBC - Triple-Negative Breast Cancer shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 16 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for TNBC - Triple-Negative Breast Cancer is led by Memorial Sloan Kettering Cancer Center with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 20 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for TNBC - Triple-Negative Breast Cancer?

PlainTrial tracks 20 US clinical trials for TNBC - Triple-Negative Breast Cancer, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for TNBC - Triple-Negative Breast Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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