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RECRUITING

CtDNA Based MRD Testing for NAC Monitoring in TNBC

NCT06230185 · View on ClinicalTrials.gov ↗

Study Summary

A prospective, multicenter, observational study to evaluate the correlation of Molecular Residual Disease (MRD) detection using circulating tumor DNA guided test to pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in stage I-III triple negative breast cancer (TNBC). Results from this study aim to improve MRD detection and disease outcomes for future patients.

Study Locations (14)

Florida

  • Mount Sinai Medical Center of Florida — Miami Beach
  • Comprehensive Hematology Oncology (ONare Alliance, LLC / Exigent Research, LLC — St. Petersburg

Arizona

  • Arizona Oncology — Tucson

Colorado

  • University of Colorado Cancer Center — Aurora

District of Columbia

  • George Washington University — Washington D.C.

Illinois

  • Illinois Cancer Care — Peoria

Louisiana

  • Louisiana State University — New Orleans

Michigan

  • Trinity Health-Michigan — Ypsilanti

Nebraska

  • Nebraska Methodist — Omaha

Trial Details

FieldValue
Enrollment Target 422 participants
Start Date 2023-11-09
Est. Completion 2025-12-31

Sponsor

Personalis

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06230185

The ClinicalTrials.gov registry entry for NCT06230185 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 422 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Personalis, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with TNBC - Triple-Negative Breast Cancer appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06230185 reports 14 study locations spanning 13 distinct geographic areas — top geographies include Florida, Arizona, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06230185 about?

NCT06230185 is a clinical study titled "CtDNA Based MRD Testing for NAC Monitoring in TNBC". A prospective, multicenter, observational study to evaluate the correlation of Molecular Residual Disease (MRD) detection using circulating tumor DNA guided test to pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in stage I-III triple negative breast cancer (TNBC). Results ...

What is the current status of trial NCT06230185?

This trial is currently recruiting. The enrollment target is 422 participants. The study started on 2023-11-09. Estimated completion is 2025-12-31.

What conditions does trial NCT06230185 study?

This clinical trial studies the following conditions: TNBC - Triple-Negative Breast Cancer, Minimal Residual Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

Who is sponsoring clinical trial NCT06230185?

This trial is sponsored by Personalis, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06230185 being conducted?

This trial has 14 study locations across Arizona, Colorado, District of Columbia, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial