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TBI (Traumatic Brain Injury) clinical trials
16 of 21 indexed TBI (Traumatic Brain Injury) trials are currently recruiting.
21 US clinical trials · 16 currently recruiting
TBI (Traumatic Brain Injury) is the subject of 21 registered US clinical trials on ClinicalTrials.gov, 16 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is University of Minnesota, running 3 of these trials.
The research picture
TBI (Traumatic Brain Injury) has 21 registered US clinical trials, 16 of them open to new participants right now, about 76% of the total.
- 16
- recruiting participants now
- 76%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 3
- top sponsor: University of Minnesota
Active & Recent Trials
21 total, page 1 of 1
Augmented Renal Clearance in Neurocritical Care
University of Alberta
NCT07410624
Emergency Department Implementation of the i-STAT Alinity Traumatic Brain Injury Whole Blood Test
Shawn Eagle
NCT07373509
Biomarkers in the Brain Oxygen Optimization in Severe Traumatic Brain Injury Trial
University of Pennsylvania
NCT04565119
Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches
Veterans Medical Research Foundation
NCT05176392
Behavioral Treatment of Insomnia in Active-Duty Service Members With Traumatic Brain Injury
Noctem
NCT06867666
Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury
University of Texas Southwestern Medical Center
NCT06480838
Mindfulness for Cognition in Early-stage Alzheimer's Disease
VA Boston Healthcare System
NCT06792877
Evaluation of Well-being Interventions in Adults With TBI
Kessler Foundation
NCT05943756
InMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBI
University of Washington
NCT06005194
Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy
Summit Hyperbarics and Wellness
NCT07214415
Cognitive Rehabilitation for Refugees With Traumatic Brain Injury and Cognitive Impairment
Massachusetts General Hospital
NCT06839079
Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury
University of Texas Southwestern Medical Center
NCT06467708
Growth Hormone Replacement Therapy for Retried Professional Football Players
Center for Neurological Studies
NCT04121780
Evaluation of Decision-Making Fatigue After Traumatic Brain Injury
University of Minnesota
NCT07103200
Stimulating After Recovery From Traumatic Brain Injury
University of Minnesota
NCT05327829
Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury
University of Minnesota
NCT05205174
Follow-up of MTBI Patients Discharged from the ED Using Standard Clinical Triage Including BrainScope One
BrainScope Company
NCT04279431
Autologous Stem Cell Study for Adult TBI (Phase 2b)
The University of Texas Health Science Center, Houston
NCT02525432
A Multi-Center Study of Near-Infrared Spectroscopy (NIRS) for Hematoma Detection
InfraScan
NCT00576147
Brain Aging in Veterans (BRAVE) Training: A Cognitive Training Pilot Trial in Older Veterans With Traumatic Brain Injury
San Francisco Veterans Affairs Medical Center
NCT02561403
VR Cognitive Rehabiliation for Pediatric TBI
University of Massachusetts, Lowell
NCT04526639
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the TBI (Traumatic Brain Injury) Trial Landscape
21 indexed TBI (Traumatic Brain Injury) studies · 16 recruiting (76%).
Phase mix: 0 late (III/IV) vs 4 early (I/II).
Top sponsor: University of Minnesota (3 trials), 9 others listed. 21 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for TBI (Traumatic Brain Injury)?
PlainTrial tracks 21 US clinical trials for TBI (Traumatic Brain Injury), of which 16 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for TBI (Traumatic Brain Injury)?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.