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ClinicalTrials.gov 16 recruiting now official registry

TBI (Traumatic Brain Injury) clinical trials

16 of 21 indexed TBI (Traumatic Brain Injury) trials are currently recruiting.

21 US clinical trials · 16 currently recruiting

TBI (Traumatic Brain Injury) is the subject of 21 registered US clinical trials on ClinicalTrials.gov, 16 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is University of Minnesota, running 3 of these trials.

The research picture

TBI (Traumatic Brain Injury) has 21 registered US clinical trials, 16 of them open to new participants right now, about 76% of the total.

16
recruiting participants now
76%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: University of Minnesota
Phase 11Phase 23

Active & Recent Trials

21 total, page 1 of 1

RECRUITING 512 participants

Augmented Renal Clearance in Neurocritical Care

University of Alberta

NCT07410624

RECRUITING 340 participants

Emergency Department Implementation of the i-STAT Alinity Traumatic Brain Injury Whole Blood Test

Shawn Eagle

NCT07373509

RECRUITING 300 participants

Biomarkers in the Brain Oxygen Optimization in Severe Traumatic Brain Injury Trial

University of Pennsylvania

NCT04565119

RECRUITING NA 240 participants

Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches

Veterans Medical Research Foundation

NCT05176392

RECRUITING NA 168 participants

Behavioral Treatment of Insomnia in Active-Duty Service Members With Traumatic Brain Injury

Noctem

NCT06867666

RECRUITING 130 participants

Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury

University of Texas Southwestern Medical Center

NCT06480838

RECRUITING NA 100 participants

Mindfulness for Cognition in Early-stage Alzheimer's Disease

VA Boston Healthcare System

NCT06792877

RECRUITING NA 94 participants

Evaluation of Well-being Interventions in Adults With TBI

Kessler Foundation

NCT05943756

RECRUITING NA 80 participants

InMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBI

University of Washington

NCT06005194

RECRUITING Phase 2 54 participants

Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy

Summit Hyperbarics and Wellness

NCT07214415

RECRUITING NA 50 participants

Cognitive Rehabilitation for Refugees With Traumatic Brain Injury and Cognitive Impairment

Massachusetts General Hospital

NCT06839079

RECRUITING NA 42 participants

Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury

University of Texas Southwestern Medical Center

NCT06467708

RECRUITING Phase 2 42 participants

Growth Hormone Replacement Therapy for Retried Professional Football Players

Center for Neurological Studies

NCT04121780

RECRUITING NA 40 participants

Evaluation of Decision-Making Fatigue After Traumatic Brain Injury

University of Minnesota

NCT07103200

RECRUITING Early Phase 1 30 participants

Stimulating After Recovery From Traumatic Brain Injury

University of Minnesota

NCT05327829

RECRUITING NA 15 participants

Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury

University of Minnesota

NCT05205174

ACTIVE NOT RECRUITING 660 participants

Follow-up of MTBI Patients Discharged from the ED Using Standard Clinical Triage Including BrainScope One

BrainScope Company

NCT04279431

ACTIVE NOT RECRUITING Phase 2 37 participants

Autologous Stem Cell Study for Adult TBI (Phase 2b)

The University of Texas Health Science Center, Houston

NCT02525432

COMPLETED NA 431 participants

A Multi-Center Study of Near-Infrared Spectroscopy (NIRS) for Hematoma Detection

InfraScan

NCT00576147

COMPLETED NA 89 participants

Brain Aging in Veterans (BRAVE) Training: A Cognitive Training Pilot Trial in Older Veterans With Traumatic Brain Injury

San Francisco Veterans Affairs Medical Center

NCT02561403

COMPLETED NA 14 participants

VR Cognitive Rehabiliation for Pediatric TBI

University of Massachusetts, Lowell

NCT04526639

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the TBI (Traumatic Brain Injury) Trial Landscape

21 indexed TBI (Traumatic Brain Injury) studies · 16 recruiting (76%).

Phase mix: 0 late (III/IV) vs 4 early (I/II).

Top sponsor: University of Minnesota (3 trials), 9 others listed. 21 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for TBI (Traumatic Brain Injury)?

PlainTrial tracks 21 US clinical trials for TBI (Traumatic Brain Injury), of which 16 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for TBI (Traumatic Brain Injury)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.