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NCT06480838 · ClinicalTrials.gov registry record

Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury

Q: What is the current status of trial NCT06480838?

This trial is currently recruiting. The enrollment target is 130 participants. The study started on 2023-09-01. Estimated completion is 2028-05-31.

Q: What conditions does trial NCT06480838 study?

This clinical trial studies the following conditions: TBI (Traumatic Brain Injury), TBI, Traumatic Brain Injury With Loss of Consciousness, Brain Injury Traumatic Severe, Brain Injury Traumatic Moderate.

Q: Who is sponsoring clinical trial NCT06480838?

This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.

Q: Where is trial NCT06480838 being conducted?

This trial has 3 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

A clinical trial of TBI (Traumatic Brain Injury) and TBI, sponsored by University of Texas Southwestern Medical Center.

Compiled by PlainTrial · August 8, 2026

Recruiting
Registry status: 130
Enrollment target: 3
Study locations

NCT06480838: Recruiting study of TBI (Traumatic Brain Injury) and TBI, sponsored by University of Texas Southwestern Medical Center.

NCT06480838 is a study of TBI (Traumatic Brain Injury) and TBI that is actively recruiting participants, run by University of Texas Southwestern Medical Center. The registered enrollment target is 130 participants, below the 167-participant average among 20 other TBI (Traumatic Brain Injury) trials with a reported enrollment target (22% lower). The trial reports 3 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT06480838, a study of TBI (Traumatic Brain Injury) and TBI, is actively recruiting participants, sponsored by University of Texas Southwestern Medical Center.

RECRUITING
Registry status: 130 participants
Enrollment target: 3
Study locations

Study Summary

Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia. The goal of this study is to determine whether acute (\< 1 week) cerebrovascular injury and its recovery within the first year postinjury measured by cerebral autoregulation and brain perfusion are associated with cognitive outcome at 12 months after msTBI. The results from this study will improve our understanding of cerebrovascular contributions to cognitive decline related to TBI and provide critical data to inform the development of strategies based on vascular mechanisms to improve cognition and prevent neurodegeneration after msTBI.

Primary Outcome

NIH Toolbox is a set of brief, comprehensive assessment tools. This study protocol will use the Cognitive battery of the Toolbox consisting of 7 subtests designed to measure executive function and attention (Flanker and Dimensional Change Card Sort), episodic memory (Picture Sequence Memory Test), working memory (List Sorting Working Memory Test), processing speed (Pattern Comparison Processing Speed and Flanker), and language (Picture Vocabulary Test). Assessments will be administered on an iPa

Conditions Studied

TBI (Traumatic Brain Injury) TBI Traumatic Brain Injury With Loss of Consciousness Brain Injury Traumatic Severe Brain Injury Traumatic Moderate

Study Locations (3)

Texas

Texas Health Presbyterian Hospital - Dallas
Parkland Health and Hospital System - Dallas
UT Southwestern Medical Center - Dallas

Trial Details

Field	Value
Enrollment Target	130 participants
Start Date	2023-09-01
Est. Completion	2028-05-31

University of Texas Southwestern Medical Center

837 total trials

What NCT06480838 shows while recruiting

NCT06480838 is an observational study that tracks outcomes without assigning an intervention. The registered 130 participants enrollment target is mid-sized for trials with a published cap, below the 167-participant average among 20 other TBI (Traumatic Brain Injury) trials with a reported enrollment target (22% lower).

The record links to 5 conditions, with TBI (Traumatic Brain Injury) appearing as the primary indexed condition, and to 0 interventions.

NCT06480838 reports a single indexed study location in Texas.

Frequently Asked Questions

What is clinical trial NCT06480838 about?

NCT06480838 is a clinical study titled "Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury". Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia. The goal of this study is to determine whether acute (\< 1 week) cerebrovascular injury...

What is the current status of trial NCT06480838?

This trial is currently recruiting. The enrollment target is 130 participants. The study started on 2023-09-01. Estimated completion is 2028-05-31.

What conditions does trial NCT06480838 study?

This clinical trial studies the following conditions: TBI (Traumatic Brain Injury), TBI, Traumatic Brain Injury With Loss of Consciousness, Brain Injury Traumatic Severe, Brain Injury Traumatic Moderate.

Who is sponsoring clinical trial NCT06480838?

This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06480838 being conducted?

This trial has 3 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for TBI (Traumatic Brain Injury)

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT06480838's enrollment target sits among peer trials

130 8th of 20 higher than 13 of 20 other TBI (Traumatic Brain Injury) trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other TBI (Traumatic Brain Injury) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT06480838, the US trial registry maintained by the National Library of Medicine. NCT06480838 (mid enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.