Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 7 recruiting now official registry

Synovial Sarcoma clinical trials

7 of 12 indexed Synovial Sarcoma trials are currently recruiting.

12 US clinical trials · 7 currently recruiting

Synovial Sarcoma is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is Uswm CT, running 2 of these trials.

The research picture

Synovial Sarcoma has 12 registered US clinical trials, 7 of them open to new participants right now, about 58% of the total.

7
recruiting participants now
58%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: Uswm CT
Phase 18Phase 22Phase 31

Active & Recent Trials

12 total, page 1 of 1

RECRUITING 1,000 participants

Synovial Sarcoma Registry / Biospecimen Repository

Children's Hospital of Philadelphia

NCT05910307

RECRUITING Phase 3 325 participants

Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)

Advenchen Laboratories

NCT03016819

RECRUITING Phase 1 44 participants

Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1

M.D. Anderson Cancer Center

NCT06083883

RECRUITING Phase 1 27 participants

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

University of Florida

NCT06625190

RECRUITING Phase 1 25 participants

HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma

Baylor College of Medicine

NCT04995003

RECRUITING Phase 1 20 participants

SPEARHEAD-3 Pediatric Study

Uswm CT

NCT05642455

RECRUITING Phase 1 15 participants

ACTengine® IMA203 Combined With mRNA-4203

Immatics US

NCT06946225

ACTIVE NOT RECRUITING Phase 1 71 participants

MAGE-A4ᶜ¹º³²T for Multi-Tumor

Adaptimmune

NCT03132922

ACTIVE NOT RECRUITING Phase 2 52 participants

Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

Uswm CT

NCT04044768

COMPLETED Phase 1 109 participants

EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma

Epizyme

NCT02601937

COMPLETED Phase 2 20 participants

Bevacizumab and Radiation Therapy for Sarcomas

Massachusetts General Hospital

NCT00356031

COMPLETED Phase 1 19 participants

Decitabine Followed by a Cancer Antigen Vaccine for Patients With Neuroblastoma and Sarcoma

University of Louisville

NCT01241162

Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 2
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Synovial Sarcoma Trial Landscape

12 indexed Synovial Sarcoma studies · 7 recruiting (58%).

Phase mix: 1 late (III/IV) vs 10 early (I/II).

Top sponsor: Uswm CT (2 trials), 9 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Synovial Sarcoma?

PlainTrial tracks 12 US clinical trials for Synovial Sarcoma, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Synovial Sarcoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.