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NCT06083883 · ClinicalTrials.gov registry record · Phase 1

Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1

A Phase 1 study of Synovial Sarcoma and Myxoid/Round Cell Liposarcoma, sponsored by M.D. Anderson Cancer Center.

Recruiting
Registry status
Phase 1
Development phase
44
Enrollment target
1
Study location

NCT06083883 is a Phase 1 study of Synovial Sarcoma and Myxoid/Round Cell Liposarcoma that is actively recruiting participants, run by M.D. Anderson Cancer Center. The registered enrollment target is 44 participants, below the 153-participant average among 11 other Synovial Sarcoma trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06083883, a Phase 1 study of Synovial Sarcoma and Myxoid/Round Cell Liposarcoma, is actively recruiting participants, sponsored by M.D. Anderson Cancer Center.

RECRUITING
Registry status
Phase 1
Development phase
44 participants
Enrollment target
1
Study location

Study Summary

The goal of this clinical research study is to find a recommended dose of donated NK cells that can be given along with chemotherapy to patients with advanced cancers. The safety and effects of this therapy will also be studied.

Conditions Studied

Synovial Sarcoma Myxoid/Round Cell Liposarcoma

Interventions

  • DRUG Cyclophosphamide
  • DRUG Fludarabine phosphate
  • DRUG NY-ESO-1 TCR/IL-15 NK

Study Locations (1)

Texas

  • MD Anderson Cancer Center - Houston

Trial Details

FieldValue
Enrollment Target 44 participants
Start Date 2024-03-27
Est. Completion 2028-11-30
Phase Phase 1

Sponsor

M.D. Anderson Cancer Center

2,692 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06083883

The ClinicalTrials.gov registry entry for NCT06083883 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 44 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 153-participant average among 11 other Synovial Sarcoma trials with a reported enrollment target (71% lower). The listed sponsor is M.D. Anderson Cancer Center, which has 2,692 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Synovial Sarcoma appearing as the primary indexed condition, and to 3 interventions - of which Cyclophosphamide is the first listed.

NCT06083883 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT06083883 about?

NCT06083883 is a clinical study titled "Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1". The goal of this clinical research study is to find a recommended dose of donated NK cells that can be given along with chemotherapy to patients with advanced cancers. The safety and effects of this therapy will also be studied.

What is the current status of trial NCT06083883?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 44 participants. The study started on 2024-03-27. Estimated completion is 2028-11-30.

What conditions does trial NCT06083883 study?

This clinical trial studies the following conditions: Synovial Sarcoma, Myxoid/Round Cell Liposarcoma.

What interventions are being tested in trial NCT06083883?

The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine phosphate (DRUG), NY-ESO-1 TCR/IL-15 NK (DRUG).

Who is sponsoring clinical trial NCT06083883?

This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06083883 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.