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ClinicalTrials.gov 37 recruiting now official registry

Stage IV Lung Cancer AJCC v8 clinical trials

37 of 82 indexed Stage IV Lung Cancer AJCC v8 trials are currently recruiting.

82 US clinical trials · 37 currently recruiting

Stage IV Lung Cancer AJCC v8 is the subject of 82 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 59 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 16 of these trials.

The research picture

Stage IV Lung Cancer AJCC v8 has 82 registered US clinical trials, 37 of them open to new participants right now, about 45% of the total.

37
recruiting participants now
45%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
16
top sponsor: National Cancer Institute (NCI)
Phase 132Phase 227Phase 38

Active & Recent Trials

82 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 1 63 participants

Olaparib and Durvalumab With Carboplatin, Etoposide, and/or Radiation Therapy for the Treatment of Extensive-Stage Small Cell Lung Cancer, PRIO Trial

M.D. Anderson Cancer Center

NCT04728230

ACTIVE NOT RECRUITING Phase 1 59 participants

Niraparib, Temozolomide and Atezolizumab in Treating Patients With Advanced Solid Tumors and Extensive-Stage Small Cell Lung Cancer With a Complete or Partial Response to Platinum-Based First-Line Chemotherapy

Jonsson Comprehensive Cancer Center

NCT03830918

ACTIVE NOT RECRUITING Phase 1 56 participants

WSD0922-FU for the Treatment of Glioblastoma, Anaplastic Astrocytoma, or Non-small Cell Lung Cancer With Central Nervous System Metastases

Mayo Clinic

NCT04197934

ACTIVE NOT RECRUITING Phase 2 55 participants

Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain Metastasis

M.D. Anderson Cancer Center

NCT04516070

ACTIVE NOT RECRUITING Phase 2 51 participants

Atezolizumab and Cobimetinib in Treating Patients With Metastatic, Recurrent, or Refractory Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT03600701

ACTIVE NOT RECRUITING Phase 1 50 participants

Single Fraction Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Non-small Cell Lung Cancer

Roswell Park Cancer Institute

NCT04073745

ACTIVE NOT RECRUITING NA 42 participants

A Nurse-Led Intervention for Fear of Progression in Advanced Cancer

City of Hope Medical Center

NCT04819997

ACTIVE NOT RECRUITING Phase 1 37 participants

Trametinib and Pembrolizumab in Treating Patients With Recurrent Non-small Cell Lung Cancer That Is Metastatic, Unresectable, or Locally Advanced

M.D. Anderson Cancer Center

NCT03225664

ACTIVE NOT RECRUITING Phase 1 35 participants

Local Consolidative Therapy and Brigatinib in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT03707938

ACTIVE NOT RECRUITING Phase 1 32 participants

Aurora Kinase Inhibitor LY3295668 in Combination With Osimertinib for the Treatment of Advanced or Metastatic EGFR-Mutant Non-squamous Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT05017025

ACTIVE NOT RECRUITING Phase 2 30 participants

Phase 2 DoceRamPem for Patients With Metastatic or Recurrent NSCLC Who Progressed on Platinum-Doublet and PD-1/PD-L1 Blockade

Emory University

NCT04340882

ACTIVE NOT RECRUITING Phase 1 28 participants

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

National Cancer Institute (NCI)

NCT04514497

ACTIVE NOT RECRUITING Phase 2 27 participants

Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy

National Cancer Institute (NCI)

NCT03965689

ACTIVE NOT RECRUITING Phase 2 25 participants

Anamorelin Hydrochloride in Reducing Anorexia in Patients With Advanced Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT03637816

ACTIVE NOT RECRUITING Phase 1 24 participants

CCL21-Gene Modified Dendritic Cell Vaccine and Pembrolizumab in Treating Patients With Stage IV Non-small Cell Lung Cancer

Jonsson Comprehensive Cancer Center

NCT03546361

ACTIVE NOT RECRUITING Phase 1 22 participants

Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT04250545

ACTIVE NOT RECRUITING Phase 1 22 participants

Telaglenastat Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT03831932

ACTIVE NOT RECRUITING Phase 1 18 participants

All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Dwight Owen

NCT04919369

ACTIVE NOT RECRUITING Phase 1 15 participants

Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors

National Cancer Institute (NCI)

NCT02589522

ACTIVE NOT RECRUITING Phase 1 12 participants

Testing the Addition of an Anti-cancer Drug, Berzosertib (M6620, VX-970), to the Usual Treatments (Carboplatin and Gemcitabine) and to Pembrolizumab for Patients With Advanced Squamous Cell Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT04216316

ACTIVE NOT RECRUITING Phase 1 12 participants

Ensartinib, Carboplatin, Pemetrexed and Bevacizumab for the Treatment of Stage IIIC or IV or Recurrent ALK-Positive Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT04837716

ACTIVE NOT RECRUITING Phase 2 10 participants

Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT03737994

ACTIVE NOT RECRUITING Phase 1 8 participants

Minnelide and Osimertinib for the Treatment of Advanced EGFR Mutated Non-Small Cell Lung Cancer

City of Hope Medical Center

NCT05166616

ACTIVE NOT RECRUITING Phase 2 7 participants

Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases

National Cancer Institute (NCI)

NCT02971501

ACTIVE NOT RECRUITING Phase 1 6 participants

Genetically Engineered Natural Killer (NK) Cells With or Without Atezolizumab for the Treatment of Non-small Cell Lung Cancer Previously Treated With PD-1 and/or PD-L1 Immune Checkpoint Inhibitors

University of California, Irvine

NCT05334329

ACTIVE NOT RECRUITING Phase 2 5 participants

A Multiple Antigen Vaccine (STEMVAC) for the Treatment of Patients With Stage IV Non-Small Cell Lung Cancer

University of Washington

NCT05242965

ACTIVE NOT RECRUITING Phase 1 5 participants

Brigatinib and Bevacizumab for the Treatment of ALK-Rearranged Locally Advanced, Metastatic, or Recurrent NSCLC

City of Hope Medical Center

NCT04227028

ACTIVE NOT RECRUITING Phase 2 5 participants

Subcutaneous Atezolizumab for the Treatment of Non-small Cell Lung Cancer

University of Southern California

NCT05340309

COMPLETED 75 participants

4D PET/CT in Diagnosing Participants With Lung and Colorectal Cancer With Liver and Lung Metastasis

M.D. Anderson Cancer Center

NCT00862680

COMPLETED NA 38 participants

Conquer Fear SUPPORT Intervention in Supporting Patients With Stage III-IV Lung or Gynecologic Cancer

City of Hope Medical Center

NCT03776253

COMPLETED NA 14 participants

Genetics and Shared Decision Making in Improving Care for Patients With Stage IVA-C Non-small Cell Lung Cancer

Thomas Jefferson University

NCT03944265

COMPLETED 2 participants

Evaluating Modifiable Biomarkers for the Prediction of Immunotherapy Response and Toxicity

Ohio State University Comprehensive Cancer Center

NCT04954885

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Phase Distribution

PhaseTrial count
Phase 1 32
Phase 2 27
Phase 3 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stage IV Lung Cancer AJCC v8 Trial Landscape

82 indexed Stage IV Lung Cancer AJCC v8 studies · 37 recruiting (45%).

Phase mix: 8 late (III/IV) vs 59 early (I/II).

Top sponsor: National Cancer Institute (NCI) (16 trials), 9 others listed. 32 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stage IV Lung Cancer AJCC v8?

PlainTrial tracks 82 US clinical trials for Stage IV Lung Cancer AJCC v8, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stage IV Lung Cancer AJCC v8?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.