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ClinicalTrials.gov 14 recruiting now official registry

Stage II Lung Cancer AJCC v8 clinical trials

14 of 25 indexed Stage II Lung Cancer AJCC v8 trials are currently recruiting.

25 US clinical trials · 14 currently recruiting

Stage II Lung Cancer AJCC v8 is the subject of 25 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 7 of these trials.

The research picture

Stage II Lung Cancer AJCC v8 has 25 registered US clinical trials, 14 of them open to new participants right now, about 56% of the total.

14
recruiting participants now
56%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
7
top sponsor: M.D. Anderson Cancer Center
Phase 13Phase 26Phase 36

Active & Recent Trials

25 total, page 1 of 1

RECRUITING Phase 3 1,210 participants

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

National Cancer Institute (NCI)

NCT04267848

RECRUITING Phase 3 1,100 participants

Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

Alliance for Clinical Trials in Oncology

NCT06632327

RECRUITING NA 400 participants

Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non-small Cell Lung or Esophageal Cancer Undergoing Radiotherapy and Their Caregivers

M.D. Anderson Cancer Center

NCT03948100

RECRUITING Phase 3 306 participants

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

National Cancer Institute (NCI)

NCT06498635

RECRUITING Phase 2 220 participants

Respiratory Muscle Training Before Surgery in Preventing Lung Complications in Patients With Stage I-IIIB Lung Cancer

Roswell Park Cancer Institute

NCT04067830

RECRUITING NA 150 participants

Quality of Life Intervention to Inform Patient Decision-Making in Early-Stage Lung Cancer

Roswell Park Cancer Institute

NCT05292521

RECRUITING NA 100 participants

The Impact of Surgical Technique on Circulating Tumor DNA in Stage I-III Non-Small Cell Lung Cancer

Thomas Jefferson University

NCT05502523

RECRUITING NA 100 participants

A Tool for Improving the Shared Decision-making Process in Patients With Non-small Cell Lung Cancer

Mayo Clinic

NCT06122064

RECRUITING NA 100 participants

New York Better Breathing Study

Roswell Park Cancer Institute

NCT06869447

RECRUITING NA 70 participants

Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study

Northwestern University

NCT05802186

RECRUITING Phase 2 60 participants

Cemiplimab and Fianlimab Before Surgery for the Treatment of Stage IB-IIIB Non-Small Cell Lung Cancer

Mayo Clinic

NCT06918132

RECRUITING Phase 2 50 participants

Canakinumab for the Prevention of Lung Cancer, the Can-Prevent-Lung Trial

M.D. Anderson Cancer Center

NCT04789681

RECRUITING NA 34 participants

Adaptive Radiation Planning for the Reduction of Radiation-Induced Toxicity in Patients With Stage II-IV Non-small Cell Lung Cancer

Rutgers, The State University of New Jersey

NCT04751747

RECRUITING Phase 1 28 participants

Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer

Ohio State University Comprehensive Cancer Center

NCT05136846

ACTIVE NOT RECRUITING Phase 3 544 participants

Testing the Addition of a New Immunotherapy Drug, Atezolizumab (MPDL3280A), to the Usual Chemoradiation (CRT) Therapy Treatment for Limited Stage Small Cell Lung Cancer (LS-SCLC)

National Cancer Institute (NCI)

NCT03811002

ACTIVE NOT RECRUITING Phase 3 480 participants

Testing the Addition of the Drug Atezolizumab to the Usual Radiation Treatment for Patients With Early Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT04214262

ACTIVE NOT RECRUITING Phase 3 403 participants

Self-Management Survivorship Care in Stage I-III Non-small Cell Lung Cancer or Colorectal Cancer

City of Hope Medical Center

NCT04428905

ACTIVE NOT RECRUITING NA 98 participants

Decision Aid for the Improvement of Decision-Making in Patients With Non-small Cell Lung Cancer

OHSU Knight Cancer Institute

NCT04946279

ACTIVE NOT RECRUITING 74 participants

Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME Study

M.D. Anderson Cancer Center

NCT04430725

ACTIVE NOT RECRUITING NA 70 participants

Online Psychosocial Intervention in Improving Social Well-Being and Support in Women With Stage I-IV Non-small Cell Lung Cancer Undergoing Treatment

M.D. Anderson Cancer Center

NCT03731585

ACTIVE NOT RECRUITING Phase 2 47 participants

Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients

National Cancer Institute (NCI)

NCT04310020

ACTIVE NOT RECRUITING Phase 2 45 participants

Pembrolizumab in Preventing Lung Cancer in Patients With Stage I-II Non-Small Cell Lung Cancer or High-Risk Pulmonary Nodules, the IMPRINT-Lung Study

M.D. Anderson Cancer Center

NCT03634241

ACTIVE NOT RECRUITING Phase 1 34 participants

NBTXR3 and Radiation Therapy for the Treatment of Inoperable Recurrent Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT04505267

ACTIVE NOT RECRUITING Phase 1 21 participants

Ipilimumab and Nivolumab in Combination With Radiation Therapy in Treating Patients With Stage 2-3 Non-small Lung Cancer

M.D. Anderson Cancer Center

NCT04013542

ACTIVE NOT RECRUITING Phase 2 5 participants

Subcutaneous Atezolizumab for the Treatment of Non-small Cell Lung Cancer

University of Southern California

NCT05340309

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 6
Phase 3 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stage II Lung Cancer AJCC v8 Trial Landscape

25 indexed Stage II Lung Cancer AJCC v8 studies · 14 recruiting (56%).

Phase mix: 6 late (III/IV) vs 9 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (7 trials), 9 others listed. 25 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stage II Lung Cancer AJCC v8?

PlainTrial tracks 25 US clinical trials for Stage II Lung Cancer AJCC v8, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stage II Lung Cancer AJCC v8?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.