Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 11 recruiting now official registry

Smoking, Cigarette clinical trials

11 of 22 indexed Smoking, Cigarette trials are currently recruiting.

22 US clinical trials · 11 currently recruiting

Smoking, Cigarette is the subject of 22 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Medical University of South Carolina, running 2 of these trials.

The research picture

Smoking, Cigarette has 22 registered US clinical trials, 11 of them open to new participants right now, about 50% of the total.

11
recruiting participants now
50%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: Medical University of South Carolina
Phase 13Phase 21

Active & Recent Trials

22 total, page 1 of 1

RECRUITING 5,122 participants

The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study

Memorial Sloan Kettering Cancer Center

NCT06535867

RECRUITING NA 900 participants

Dyadic Financial Incentive Treatments for Dual Smoker Couples

University of Georgia

NCT06296849

RECRUITING NA 768 participants

Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia

University of Virginia

NCT05660525

RECRUITING NA 231 participants

Optimizing Tobacco Treatment Delivery for People Living With HIV

Medical University of South Carolina

NCT05019495

RECRUITING 200 participants

University of Michigan COPD Identification Through Lung Cancer Screening Cohort Study - MAP2

University of Michigan

NCT07482475

RECRUITING Phase 1 100 participants

Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation

University of Pennsylvania

NCT03721822

RECRUITING 100 participants

Vape Use Among Younger & Older Smokers

Abramson Cancer Center at Penn Medicine

NCT07214168

RECRUITING NA 50 participants

ACT Lung Health Intervention: Phase Two

Dana-Farber Cancer Institute

NCT06945120

RECRUITING NA 48 participants

Maternal Smoking Cessation and Pediatric Obesity Prevention

State University of New York at Buffalo

NCT03514602

RECRUITING NA 20 participants

Trauma-Informed Care for Smoking Cessation for Pregnancy

University of California, San Francisco

NCT07129590

RECRUITING NA 10 participants

A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home

Memorial Sloan Kettering Cancer Center

NCT06693700

ACTIVE NOT RECRUITING Phase 1 47 participants

Biomarkers of Exposure and Effect in Standardized Research E-cigarette (SREC) Users

Masonic Cancer Center, University of Minnesota

NCT04003805

COMPLETED NA 1,944 participants

Helping Poor Smokers Quit

Washington University School of Medicine

NCT03194958

COMPLETED NA 663 participants

Tobacco/Nicotine Purchase Patterns Across SES

Virginia Polytechnic Institute and State University

NCT06795997

COMPLETED NA 433 participants

The Impact of Standardized Tobacco Product Packaging on Young Adults in the Retail Environment

RAND

NCT05973981

COMPLETED NA 165 participants

A Facebook Intervention for Young Sexual and Gender Minority Smokers

University of California, San Francisco

NCT03259360

COMPLETED Early Phase 1 99 participants

Hollings Cancer Center Varenicline Sampling Study

Medical University of South Carolina

NCT03742154

COMPLETED NA 95 participants

Personalized Feedback for Smokers With Elevated Anxiety Sensitivity

University of Houston

NCT03382093

COMPLETED NA 70 participants

FDA Cigarette Warning Labels: Eye Tracking Study

Abramson Cancer Center at Penn Medicine

NCT04936724

COMPLETED NA 61 participants

Connecting Alaska Native People to Quit Smoking

Mayo Clinic

NCT03645941

COMPLETED Phase 2 58 participants

AXS-05 Phase II Trial on Smoking Behavior

James Davis

NCT03471767

COMPLETED 30 participants

A Comparison of Exhaled Carbon Monoxide Measurements Using the iCOquit Smokerlyzer and Vitalograph Breath CO Monitor vs Carboxyhemoglobin From Venous Samples While Validating a Mobile Research Application

Rose Research Center

NCT04826549

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Smoking, Cigarette Trial Landscape

22 indexed Smoking, Cigarette studies · 11 recruiting (50%).

Phase mix: 0 late (III/IV) vs 4 early (I/II).

Top sponsor: Medical University of South Carolina (2 trials), 9 others listed. 22 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Smoking, Cigarette?

PlainTrial tracks 22 US clinical trials for Smoking, Cigarette, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Smoking, Cigarette?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.