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ClinicalTrials.gov 5 recruiting now official registry

Short Bowel Syndrome clinical trials

Every US clinical trial registered for Short Bowel Syndrome — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

18 US clinical trials · 5 currently recruiting

The research picture

Short Bowel Syndrome has 18 registered US clinical trials, 5 of them open to new participants right now — about 28% of the total.

5
recruiting participants now
28%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
4
top sponsor: Zealand Pharma

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 3 90 participants

Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS

Zealand Pharma

NCT07197944

RECRUITING NA 40 participants

A Feasibility Study to Evaluate Safety and Probable Benefit of the Eclipse XL1 System for Distraction Enterogenesis in Adult and Pediatric Patients With Short Bowel Syndrome

Eclipse Regenesis

NCT05535361

RECRUITING NA 32 participants

A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB

Boston Children's Hospital

NCT03530852

RECRUITING Phase 2 18 participants

Phase 2 Study to Assess the Safety, PK, and PD of Sonefpeglutide (HM15912) in SBS-IF Subjects

Hanmi Pharmaceutical Company Limited

NCT04775706

RECRUITING Early Phase 1 6 participants

Open-Label Pilot Study With Crofelemer in Patients With Short Bowel Syndrome

Lindsey Russell, MD

NCT06326645

ACTIVE NOT RECRUITING 1,806 participants

Registry for Participants With Short Bowel Syndrome

Shire

NCT01990040

ACTIVE NOT RECRUITING Phase 3 158 participants

Open-label Extension Trial to Evaluate the Long-term Safety of Apraglutide in Short Bowel Syndrome.

VectivBio

NCT05018286

ACTIVE NOT RECRUITING Phase 3 145 participants

Evaluation of Long Term Safety and Efficacy of Glepaglutide in Treatment of SBS

Zealand Pharma

NCT03905707

ACTIVE NOT RECRUITING Phase 3 129 participants

Evaluation of Long Term Safety and Efficacy of Glepaglutide in Treatment of SBS - Extension Trial

Zealand Pharma

NCT04881825

COMPLETED Phase 3 164 participants

Trial to Evaluate Efficacy and Safety of Apraglutide in SBS-IF

VectivBio

NCT04627025

COMPLETED 142 participants

Pediatric Teduglutide Registry

Boston Children's Hospital

NCT04832087

COMPLETED Phase 3 106 participants

Efficacy And Safety Evaluation of Glepaglutide in Treatment of Short Bowel Syndrome (SBS)

Zealand Pharma

NCT03690206

COMPLETED Phase 3 88 participants

Open-Label Study of Teduglutide for Subjects With PN-Dependent Short Bowel Syndrome (SBS)

Shire

NCT00930644

COMPLETED Phase 3 84 participants

Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome

Shire

NCT00081458

COMPLETED Phase 3 61 participants

Long-term Safety and Efficacy Study of Teduglutide in Pediatric Participants With Short Bowel Syndrome (SBS)

Shire

NCT02954458

COMPLETED Early Phase 1 40 participants

Early Provision of Enteral Microlipid and Fish Oil to Infants With Enterostomy

Wake Forest University

NCT01306838

COMPLETED 25 participants

Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure Patients

Christopher Duggan

NCT02561819

COMPLETED Phase 4 8 participants

rtPA in in the Prevention of CVAD-Associated Thrombosis and Infection in Pediatric Patients With Short Bowel Syndrome

Lynn Malec

NCT02355743

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 1
Phase 3 9
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Short Bowel Syndrome Trial Landscape

ClinicalTrials.gov lists 18 US studies indexed under Short Bowel Syndrome, and 5 of those are currently open to recruitment — roughly 28% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Short Bowel Syndrome shows 10 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Short Bowel Syndrome is led by Zealand Pharma with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 18 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Short Bowel Syndrome?

PlainTrial tracks 18 US clinical trials for Short Bowel Syndrome, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Short Bowel Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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