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Short Bowel Syndrome clinical trials
5 of 18 indexed Short Bowel Syndrome trials are currently recruiting.
18 US clinical trials · 5 currently recruiting
Short Bowel Syndrome is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Zealand Pharma, running 4 of these trials.
The research picture
Short Bowel Syndrome has 18 registered US clinical trials, 5 of them open to new participants right now, about 28% of the total.
- 5
- recruiting participants now
- 28%
- of trials open to enrollment
- 10
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Zealand Pharma
Active & Recent Trials
18 total, page 1 of 1
Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS
Zealand Pharma
NCT07197944
A Feasibility Study to Evaluate Safety and Probable Benefit of the Eclipse XL1 System for Distraction Enterogenesis in Adult and Pediatric Patients With Short Bowel Syndrome
Eclipse Regenesis
NCT05535361
A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB
Boston Children's Hospital
NCT03530852
Phase 2 Study to Assess the Safety, PK, and PD of Sonefpeglutide (HM15912) in SBS-IF Subjects
Hanmi Pharmaceutical Company Limited
NCT04775706
Open-Label Pilot Study With Crofelemer in Patients With Short Bowel Syndrome
Lindsey Russell, MD
NCT06326645
Registry for Participants With Short Bowel Syndrome
Shire
NCT01990040
Open-label Extension Trial to Evaluate the Long-term Safety of Apraglutide in Short Bowel Syndrome.
VectivBio
NCT05018286
Evaluation of Long Term Safety and Efficacy of Glepaglutide in Treatment of SBS
Zealand Pharma
NCT03905707
Evaluation of Long Term Safety and Efficacy of Glepaglutide in Treatment of SBS - Extension Trial
Zealand Pharma
NCT04881825
Trial to Evaluate Efficacy and Safety of Apraglutide in SBS-IF
VectivBio
NCT04627025
Pediatric Teduglutide Registry
Boston Children's Hospital
NCT04832087
Efficacy And Safety Evaluation of Glepaglutide in Treatment of Short Bowel Syndrome (SBS)
Zealand Pharma
NCT03690206
Open-Label Study of Teduglutide for Subjects With PN-Dependent Short Bowel Syndrome (SBS)
Shire
NCT00930644
Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome
Shire
NCT00081458
Long-term Safety and Efficacy Study of Teduglutide in Pediatric Participants With Short Bowel Syndrome (SBS)
Shire
NCT02954458
Early Provision of Enteral Microlipid and Fish Oil to Infants With Enterostomy
Wake Forest University
NCT01306838
Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure Patients
Christopher Duggan
NCT02561819
rtPA in in the Prevention of CVAD-Associated Thrombosis and Infection in Pediatric Patients With Short Bowel Syndrome
Lynn Malec
NCT02355743
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 1 |
| Phase 3 | 9 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Short Bowel Syndrome Trial Landscape
18 indexed Short Bowel Syndrome studies · 5 recruiting (28%).
Phase mix: 10 late (III/IV) vs 3 early (I/II).
Top sponsor: Zealand Pharma (4 trials), 9 others listed. 18 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Short Bowel Syndrome?
PlainTrial tracks 18 US clinical trials for Short Bowel Syndrome, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Short Bowel Syndrome?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.