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ClinicalTrials.gov 6 recruiting now early-phase tilt small index

SCLC: early-phase trial registry

6 of 11 indexed SCLC trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,577 of 28,707 conditions by registered trial count.

11 US clinical trials · 6 currently recruiting · #1,577 of 28,707 conditions by registered trial count

SCLC: 11 US clinical trials tracked, 6 recruiting.

SCLC is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 2 of these trials.

Enrollment posture brief

Registry condition sclc

OPEN 6 | RECR 55% | LATE 0 | EARLY 9 | RANK #1577 | SPON 2

Nearest open-share peer: Advanced Ovarian Carcinoma (55% recruiting · 11 trials)

Acute Pancreatitis81.8%SCLC (this)55%Acute Stroke45.5%Acquired Brain Injury36.4%Acute Lung Injury9.1%
Open-enrollment share among volume-matched conditions near SCLC

SCLC lists 6 open slots (55% of 11 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for SCLC on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. SCLC is recruiting above its size-band peers.

    6 of 11 indexed trials (54.5%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates SCLC research.

    National Cancer Institute (NCI) accounts for 2 of 11 trials (18.2%). 10 distinct sponsors appear on at least one study for this condition label.

  3. Typical SCLC enrolment sits around 120 participants.

    Median target enrolment is 120 among the 11 trials that report a genuine target (sentinel values excluded). 4 of those (36.4%) plan for fewer than 100 participants.

  4. SCLC research is mostly interventional.

    11 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 18Phase 21

Open and recent trials

11 total, page 1 of 1

RECRUITING Phase 1 250 participants

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

Tubulis

NCT06657222

RECRUITING NA 244 participants

Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy

Wake Forest University Health Sciences

NCT05703269

RECRUITING Phase 1 120 participants

A Phase I/II Study of Sacituzumab Govitecan Plus Berzosertib in Small Cell Lung Cancer, Extra-Pulmonary Small Cell Neuroendocrine Cancer and Homologous Recombination-Deficient Cancers Resistant to PARP Inhibitors

National Cancer Institute (NCI)

NCT04826341

RECRUITING Phase 1 112 participants

A Study of ZL-1310 in Subjects With Small Cell Lung Cancer

Zai Lab (Shanghai) Co.

NCT06179069

RECRUITING Phase 1 70 participants

SLV-154 Treatment of Metastatic Solid Tumors

Solve Therapeutics

NCT06771219

RECRUITING Phase 1 60 participants

GD2-SADA:177Lu-DOTA Complex in Patients With Solid Tumors Known to Express GD2

Y-mAbs Therapeutics

NCT05130255

ACTIVE NOT RECRUITING Phase 2 600 participants

Pharmacogenomics ANDA SNP Clinical Study - Topotecan and Single Nucleotide Polymorphisms

Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair

NCT07145333

ACTIVE NOT RECRUITING Phase 1 264 participants

A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors.

AstraZeneca

NCT02734004

ACTIVE NOT RECRUITING Phase 1 174 participants

Study of Oral MRT-2359 in Selected Cancer Patients

Monte Rosa Therapeutics

NCT05546268

ACTIVE NOT RECRUITING Phase 1 37 participants

Lurbinectedin With Berzosertib, an ATR Kinase Inhibitor in Small Cell Cancers and High-Grade Neuroendocrine Cancers

National Cancer Institute (NCI)

NCT04802174

COMPLETED NA 20 participants

Hippocampal Prophylactic Cranial Irradiation for Small Cell Lung Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT01797159

Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 1

Named interventions

Most-linked intervention names on SCLC records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Berzosertib Drug
2 trials
Hippocampal-sparing Prophylactic Cranial Irradiation Radiation
1 trials
Oral MRT-2359 Drug
1 trials
Topotecan - study Drug
1 trials
Topotecan - usual Drug
1 trials
MEDI4736 Drug
1 trials
fractionated stereotactic radiosurgery (FSRS) Radiation
1 trials
single fraction stereotactic radiosurgery (SSRS) Radiation
1 trials

US sites by state

Facility locations filed on SCLC trials. A trial with sites in several states counts in each.

New York 6 trials
Missouri 5 trials
Michigan 5 trials
Maryland 5 trials
Ohio 4 trials
California 4 trials
Washington 3 trials
Texas 3 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this SCLC page

11 registered trials, 6 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This SCLC condition card totals 11 registered trials; most-linked intervention Berzosertib; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.