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ACTIVE NOT RECRUITING Phase 1

A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors.

NCT02734004 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to look at the effectiveness, safety, and antitumor activity of study drugs MEDI4736 in combination with olaparib (modules 1, 2, 3, 4, 5 and 7) and MEDI4736 in combination with olaparib and bevacizumab (module 6). It will also examine what happens to the study drugs in the body and investigate how well the combination between MEDI4736, olaparib and bevacizumab is tolerated.

Interventions

  • DRUG Bevacizumab
  • DRUG Olaparib
  • DRUG MEDI4736

Study Locations (20)

Other

  • Research Site — Bordeaux
  • Research Site — Caen
  • Research Site — Clermont-Ferrand
  • Research Site — Dijon
  • Research Site — Marseille
  • Research Site — Nantes
  • Research Site — Paris
  • Research Site — Pierre Benit Cedex
  • Research Site — Toulouse
  • Research Site — Villejuif
  • Research Site — Haifa
  • Research Site — Jerusalem
  • Research Site — Petah Tikva

Georgia

  • Research Site — Newnan

Maryland

  • Research Site — Towson

Massachusetts

  • Research Site — Boston

Michigan

  • Research Site — Detroit

Missouri

  • Research Site — St Louis

Ohio

  • Research Site — Hilliard

Pennsylvania

  • Research Site — Philadelphia

Trial Details

FieldValue
Enrollment Target 264 participants
Start Date 2016-03-17
Est. Completion 2026-09-17
Phase Phase 1

Sponsor

AstraZeneca

1,053 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02734004

The ClinicalTrials.gov registry entry for NCT02734004 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 264 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with SCLC appearing as the primary indexed condition, and to 3 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02734004 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, Georgia, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02734004 about?

NCT02734004 is a clinical study titled "A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors.". The purpose of this study is to look at the effectiveness, safety, and antitumor activity of study drugs MEDI4736 in combination with olaparib (modules 1, 2, 3, 4, 5 and 7) and MEDI4736 in combination with olaparib and bevacizumab (module 6). It will also examine what happens to the study drugs in t...

What is the current status of trial NCT02734004?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 264 participants. The study started on 2016-03-17. Estimated completion is 2026-09-17.

What conditions does trial NCT02734004 study?

This clinical trial studies the following conditions: SCLC, Breast, Gastric Cancers, Ovarian. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02734004?

The interventions under investigation include: Bevacizumab (DRUG), Olaparib (DRUG), MEDI4736 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02734004?

This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02734004 being conducted?

This trial has 20 study locations across Georgia, Maryland, Massachusetts, Michigan, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial