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ClinicalTrials.gov 36 recruiting now official registry

Refractory Acute Myeloid Leukemia clinical trials

36 of 64 indexed Refractory Acute Myeloid Leukemia trials are currently recruiting.

64 US clinical trials · 36 currently recruiting

Refractory Acute Myeloid Leukemia is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 36 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 20 of these trials.

The research picture

Refractory Acute Myeloid Leukemia has 64 registered US clinical trials, 36 of them open to new participants right now, about 56% of the total.

36
recruiting participants now
56%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
20
top sponsor: M.D. Anderson Cancer Center
Phase 152Phase 212

Active & Recent Trials

64 total, page 1 of 2

RECRUITING Phase 1 170 participants

A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

BlossomHill Therapeutics

NCT06501196

RECRUITING Phase 1 120 participants

CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia

Fred Hutchinson Cancer Center

NCT04375631

RECRUITING Phase 1 120 participants

ONC201 in Treating Patients With Relapsed or Refractory Acute Leukemia or High-Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT02392572

RECRUITING Phase 1 116 participants

Venetoclax With Combination Chemotherapy in Treating Patients With Newly Diagnosed or Relapsed or Refractory Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT03214562

RECRUITING Phase 1 97 participants

Azacitidine, Venetoclax, and Gilteritinib in Treating Patients With Recurrent/Refractory FLT3-Mutated Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, or High-Risk Myelodysplastic Syndrome/Myeloproliferative Neoplasm

M.D. Anderson Cancer Center

NCT04140487

RECRUITING Phase 1 96 participants

Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies

M.D. Anderson Cancer Center

NCT03471260

RECRUITING Phase 1 84 participants

Decitabine/Cedazuridine and Venetoclax in Combination With Ivosidenib or Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT04774393

RECRUITING Phase 1 80 participants

Cladribine, Idarubicin, Cytarabine, and Quizartinib in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT04047641

RECRUITING Phase 1 75 participants

211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia

Fred Hutchinson Cancer Center

NCT03128034

RECRUITING Phase 1 73 participants

Quizartinib, Decitabine, and Venetoclax in Treating Participants With Untreated or Relapsed Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT03661307

RECRUITING Phase 1 62 participants

Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms

University of Washington

NCT04797767

RECRUITING Phase 1 60 participants

Eltanexor and Venetoclax in Relapsed or Refractory Myelodysplastic Syndrome and Acute Myeloid Leukemia

Vanderbilt-Ingram Cancer Center

NCT06399640

RECRUITING Phase 1 54 participants

Pembrolizumab and Decitabine With or Without Venetoclax in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome That Is Newly-Diagnosed, Recurrent, or Refractory

City of Hope Medical Center

NCT03969446

RECRUITING Phase 1 54 participants

Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

National Cancer Institute (NCI)

NCT06484062

RECRUITING Phase 1 52 participants

Liposomal Cytarabine and Daunorubicin (CPX-351) and Quizartinib for the Treatment of Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT04128748

RECRUITING Phase 2 52 participants

Liposome-encapsulated Daunorubicin-Cytarabine and Venetoclax in Treating Participants With Relapsed, Refractory or Untreated Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT03629171

RECRUITING Phase 1 51 participants

Ruxolitinib in Combination With Venetoclax With and Without Azacitidine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Jennifer Saultz

NCT03874052

RECRUITING Phase 2 50 participants

Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation

M.D. Anderson Cancer Center

NCT03683433

RECRUITING Phase 1 42 participants

TAK-243 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndromes With Increased Blasts

National Cancer Institute (NCI)

NCT03816319

RECRUITING Phase 1 42 participants

ASTX727, Venetoclax, and Gilteritinib for the Treatment of Newly Diagnosed, Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT05010122

RECRUITING Phase 1 36 participants

Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse

Fred Hutchinson Cancer Center

NCT06928662

RECRUITING Phase 1 30 participants

8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia

City of Hope Medical Center

NCT05263284

RECRUITING Phase 1 30 participants

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

Fred Hutchinson Cancer Center

NCT03670966

RECRUITING Phase 2 30 participants

CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT04493164

RECRUITING Phase 1 30 participants

SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

Uma Borate

NCT06222580

RECRUITING Phase 1 28 participants

Vyxeos for Re-induction Treatment of Acute Myeloid Leukemia Patients With Persistent Disease After Induction

Ohio State University Comprehensive Cancer Center

NCT04049539

RECRUITING Phase 1 27 participants

CD33-CAR T Cell Therapy for the Treatment of Recurrent or Refractory Acute Myeloid Leukemia

City of Hope Medical Center

NCT05672147

RECRUITING Phase 1 26 participants

Genetically Engineered Cells (CD83 CAR T Cells) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Roswell Park Cancer Institute

NCT06871410

RECRUITING Phase 1 24 participants

Tazemetostat and Palbociclib With CPX-351for R/R AML

Thomas Jefferson University

NCT05627232

RECRUITING Phase 1 24 participants

Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

St. Jude Children's Research Hospital

NCT06177067

RECRUITING Phase 1 20 participants

Tagraxofusp and Low-Intensity Chemotherapy for CD123-Positive Relapsed or Refractory AML

Stanford University

NCT06561152

RECRUITING Phase 1 18 participants

CER-1236 in Patients With Acute Myeloid Leukemia (AML)

CERo Therapeutics Holdings

NCT06834282

RECRUITING Phase 1 18 participants

Venetoclax and Bomedemstat in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Terrence J Bradley, MD

NCT05597306

RECRUITING Phase 1 15 participants

A Study of CD371-YSNVZIL-18 CAR T Cells in People With Acute Myeloid Leukemia

Memorial Sloan Kettering Cancer Center

NCT06017258

RECRUITING Phase 1 12 participants

MiRisten for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

City of Hope Medical Center

NCT07025564

RECRUITING Phase 1 12 participants

A Phase 1 Study of AOH1996 in Patients With Relapsed/Refractory Acute Myeloid Leukemia

City of Hope Medical Center

NCT06763341

ACTIVE NOT RECRUITING Phase 1 144 participants

FHD-286 as Monotherapy or Combination Therapy in Subjects With Advanced Hematologic Malignancies

Foghorn Therapeutics

NCT04891757

ACTIVE NOT RECRUITING Phase 2 85 participants

Venetoclax and ASTX727 for the Treatment of Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT04746235

ACTIVE NOT RECRUITING Phase 1 74 participants

Sorafenib, Busulfan and Fludarabine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia Undergoing Donor Stem Cell Transplant

M.D. Anderson Cancer Center

NCT03247088

ACTIVE NOT RECRUITING Phase 1 58 participants

Testing a New Chemotherapy Drug, KRT-232 (AMG-232) in Combination With Decitabine and Venetoclax in Patients With Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT03041688

ACTIVE NOT RECRUITING Phase 1 54 participants

Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT02890329

ACTIVE NOT RECRUITING Phase 2 50 participants

Liposome-encapsulated Daunorubicin-Cytarabine and Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) or High Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT03672539

ACTIVE NOT RECRUITING Phase 1 48 participants

Testing the Addition of an Anti-cancer Drug, M3814, to the Usual Treatment (Mitoxantrone, Etoposide, and Cytarabine) for Relapsed or Refractory Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT03983824

ACTIVE NOT RECRUITING Phase 1 44 participants

Nintedanib and Azacitidine in Treating Participants With HOX Gene Overexpression Relapsed or Refractory Acute Myeloid Leukemia

Northwestern University

NCT03513484

ACTIVE NOT RECRUITING Phase 1 37 participants

Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

St. Jude Children's Research Hospital

NCT04898894

ACTIVE NOT RECRUITING Phase 1 32 participants

Palbociclib and Sorafenib, Decitabine, or Dexamethasone in Treating Patients With Recurrent or Refractory Leukemia

M.D. Anderson Cancer Center

NCT03132454

ACTIVE NOT RECRUITING Phase 1 30 participants

Pevonedistat and Decitabine in Treating Patients With High Risk Acute Myeloid Leukemia

City of Hope Medical Center

NCT03009240

ACTIVE NOT RECRUITING Phase 2 25 participants

Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia

National Cancer Institute (NCI)

NCT03289910

ACTIVE NOT RECRUITING Phase 2 20 participants

Venetoclax in Combination With Decitabine and Cedazuridine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT04975919

ACTIVE NOT RECRUITING Phase 2 20 participants

Decitabine, Venetoclax, and Ponatinib for the Treatment of Philadelphia Chromosome-Positive Acute Myeloid Leukemia or Myeloid Blast Phase or Accelerated Phase Chronic Myelogenous Leukemia

M.D. Anderson Cancer Center

NCT04188405

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Phase Distribution

PhaseTrial count
Phase 1 52
Phase 2 12

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory Acute Myeloid Leukemia Trial Landscape

64 indexed Refractory Acute Myeloid Leukemia studies · 36 recruiting (56%).

Phase mix: 0 late (III/IV) vs 64 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (20 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory Acute Myeloid Leukemia?

PlainTrial tracks 64 US clinical trials for Refractory Acute Myeloid Leukemia, of which 36 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory Acute Myeloid Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.