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ClinicalTrials.gov 36 recruiting now official registry

Refractory Acute Myeloid Leukemia clinical trials

36 of 64 indexed Refractory Acute Myeloid Leukemia trials are currently recruiting.

64 US clinical trials · 36 currently recruiting

Refractory Acute Myeloid Leukemia is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 36 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 20 of these trials.

The research picture

Refractory Acute Myeloid Leukemia has 64 registered US clinical trials, 36 of them open to new participants right now, about 56% of the total.

36
recruiting participants now
56%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
20
top sponsor: M.D. Anderson Cancer Center
Phase 152Phase 212

Active & Recent Trials

64 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 1 17 participants

Navitoclax, Venetoclax, and Decitabine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Previously Treated With Venetoclax

City of Hope Medical Center

NCT05222984

ACTIVE NOT RECRUITING Phase 1 16 participants

Flotetuzumab for the Treatment of Pediatric Recurrent or Refractory Acute Myeloid Leukemia

Children's Oncology Group

NCT04158739

ACTIVE NOT RECRUITING Phase 2 14 participants

Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation

National Cancer Institute (NCI)

NCT03953898

ACTIVE NOT RECRUITING Phase 2 13 participants

CPX-351 as a Novel Approach for the Treatment of Older Patients With AML and MDS

Case Comprehensive Cancer Center

NCT04668885

ACTIVE NOT RECRUITING Phase 1 13 participants

Entrectinib in Combination With ASTX727 for the Treatment of Relapsed/Refractory TP53 Mutated Acute Myeloid Leukemia

OHSU Knight Cancer Institute

NCT05396859

ACTIVE NOT RECRUITING Phase 1 8 participants

Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell Membrane

National Cancer Institute (NCI)

NCT05146739

ACTIVE NOT RECRUITING Phase 1 3 participants

Enasidenib in Combination With Cobimetinib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

City of Hope Medical Center

NCT05441514

ACTIVE NOT RECRUITING Phase 1 2 participants

Ivosidenib and Combination Chemotherapy for the Treatment of IDH1 Mutant Relapsed or Refractory Acute Myeloid Leukemia

Northwestern University

NCT04250051

ACTIVE NOT RECRUITING Phase 2 1 participants

Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With an IDH2 Mutation

Children's Oncology Group

NCT04203316

COMPLETED Phase 2 150 participants

Nivolumab and Azacitidine With or Without Ipilimumab in Treating Patients With Refractory/Relapsed or Newly Diagnosed Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT02397720

COMPLETED Phase 1 30 participants

Donor Natural Killer Cells in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT01787474

COMPLETED Phase 1 28 participants

Decitabine With GCLAM for Adults With Newly Diagnosed, Relapsed, or Refractory AML or High-Risk MDS

Fred Hutchinson Cancer Center

NCT02921061

COMPLETED Phase 1 20 participants

8-Chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

City of Hope Medical Center

NCT02509546

COMPLETED Phase 1 19 participants

Trial Testing Safety of IL-21 NK Cells for Induction of R/R AML

Sumithira Vasu

NCT04220684

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Phase Distribution

PhaseTrial count
Phase 1 52
Phase 2 12

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory Acute Myeloid Leukemia Trial Landscape

64 indexed Refractory Acute Myeloid Leukemia studies · 36 recruiting (56%).

Phase mix: 0 late (III/IV) vs 64 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (20 trials), 9 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory Acute Myeloid Leukemia?

PlainTrial tracks 64 US clinical trials for Refractory Acute Myeloid Leukemia, of which 36 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory Acute Myeloid Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.