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2026 data Public-data reference. official source

Recurrent Endometrial Carcinoma

Open-data reference.

20 US clinical trials · 11 currently recruiting

Active & Recent Trials

RECRUITING Phase 2 2,900 participants

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

National Cancer Institute (NCI)

NCT05564377

RECRUITING Phase 3 255 participants

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

National Cancer Institute (NCI)

NCT07198074

RECRUITING Phase 2 165 participants

Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial

National Cancer Institute (NCI)

NCT05554328

RECRUITING Phase 2 81 participants

Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

National Cancer Institute (NCI)

NCT05112601

RECRUITING Phase 1 60 participants

Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer

National Cancer Institute (NCI)

NCT05950464

RECRUITING Phase 1 42 participants

Testing the Combination of APG-1252 (Pelcitoclax) and Cobimetinib in Recurrent Ovarian and Endometrial Cancers

National Cancer Institute (NCI)

NCT05691504

RECRUITING Phase 2 32 participants

Abemaciclib for the Treatment of Recurrent Ovarian or Endometrial Cancer

Jonsson Comprehensive Cancer Center

NCT04469764

RECRUITING Phase 2 29 participants

Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer

Aadi Bioscience

NCT05997017

RECRUITING Phase 2 25 participants

Avelumab and M1774 in ARID1A-mutated Endometrial Cancer

Panagiotis Konstantinopoulos, MD, PhD

NCT06518564

RECRUITING Phase 1 24 participants

Talazoparib and Radiation Therapy in Treating Patients With Locally Recurrent Gynecologic Cancers

M.D. Anderson Cancer Center

NCT03968406

RECRUITING Phase 1 18 participants

Phase 1 Clinical Trial of Lenvatinib, Pembrolizumab and Hypofractionated Pelvic Radiation Therapy for pMMR Recurrent/Unresectable Endometrial Carcinoma

Aaron Wolfson

NCT05603910

ACTIVE NOT RECRUITING Phase 3 813 participants

Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer

National Cancer Institute (NCI)

NCT03914612

ACTIVE NOT RECRUITING Phase 2 90 participants

A Phase II, Two-Arm Study of Everolimus and Letrozole, +/- Ribociclib (Lee011) in Patients With Advanced or Recurrent Endometrial Carcinoma

M.D. Anderson Cancer Center

NCT03008408

ACTIVE NOT RECRUITING Phase 2 82 participants

Cabozantinib S-malate and Nivolumab in Treating Patients With Advanced, Recurrent, or Metastatic Endometrial Cancer

National Cancer Institute (NCI)

NCT03367741

ACTIVE NOT RECRUITING Phase 2 38 participants

Lenvatinib, Pembrolizumab, and Paclitaxel for Treatment of Recurrent Endometrial, Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Floor Backes, MD

NCT04781088

ACTIVE NOT RECRUITING Phase 1 34 participants

VSV-hIFNbeta-NIS With or Without Ruxolitinib Phosphate in Treating Stage IV or Recurrent Endometrial Cancer

Mayo Clinic

NCT03120624

ACTIVE NOT RECRUITING Phase 1 31 participants

Niraparib and Copanlisib in Treating Patients With Recurrent Endometrial, Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

M.D. Anderson Cancer Center

NCT03586661

COMPLETED Phase 2 50 participants

Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies

Case Comprehensive Cancer Center

NCT01079832

COMPLETED Phase 1 18 participants

Interleukin-12, Paclitaxel, and Trastuzumab in Treating Patients With Solid Tumors

National Cancer Institute (NCI)

NCT00028535

COMPLETED Phase 1 12 participants

Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer

Case Comprehensive Cancer Center

NCT01652794

Phase Distribution

PhaseTrial count
Early Phase 1 8
Phase 2 10
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Recurrent Endometrial Carcinoma Trial Landscape

ClinicalTrials.gov lists 20 US studies indexed under Recurrent Endometrial Carcinoma, and 11 of those are currently open to recruitment — roughly 55% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Recurrent Endometrial Carcinoma shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 18 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Recurrent Endometrial Carcinoma is led by National Cancer Institute (NCI) with 9 indexed trials, alongside 8 other organizations in the top contributor list. The list on this page surfaces up to 20 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Recurrent Endometrial Carcinoma?

PlainTrial tracks 20 US clinical trials for Recurrent Endometrial Carcinoma, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Recurrent Endometrial Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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