Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Propionic Acidemia: early-phase trial registry
5 of 7 indexed Propionic Acidemia trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #2,497 of 28,707 conditions by registered trial count.
7 US clinical trials · 5 currently recruiting · #2,497 of 28,707 conditions by registered trial count
Propionic Acidemia: 7 US clinical trials tracked, 5 recruiting.
Propionic Acidemia is the subject of 7 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is ModernaTX, running 4 of these trials.
Enrollment posture brief
Registry condition propionic-acidemia
OPEN 5 | RECR 71% | LATE 0 | EARLY 3 | RANK #2497 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Advanced Endometrial Carcinoma (71% recruiting · 7 trials)
Propionic Acidemia lists 5 open slots (71% of 7 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Propionic Acidemia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Propionic Acidemia is recruiting above its size-band peers.
5 of 7 indexed trials (71.4%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Propionic Acidemia research.
ModernaTX accounts for 4 of 7 trials (57.1%). 4 distinct sponsors appear on at least one study for this condition label.
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Most Propionic Acidemia trials plan to enrol fewer than 100 people.
Median target enrolment is 60 among the 7 trials that report a genuine target (sentinel values excluded). 6 of those (85.7%) plan for fewer than 100 participants.
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Propionic Acidemia splits between interventional and observational designs.
3 interventional and 4 observational studies make up this index (42.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
7 total, page 1 of 1
Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia
National Human Genome Research Institute (NHGRI)
NCT02890342
Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia
ModernaTX
NCT04159103
A Retrospective Study to Characterize Participants With Propionic Acidemia
ModernaTX
NCT05769621
A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study
ModernaTX
NCT05130437
An Observational Study of Carbaglu® for the Treatment of MMA and PA in Adults and Pediatrics
Recordati Group
NCT05040178
"The MaP Study": Mapping the Patient Journey in MMA and PA
ModernaTX
NCT03484767
Anaplerotic Therapy in Propionic Acidemia
Nicola Longo
NCT00645879
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Propionic Acidemia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Propionic Acidemia trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Propionic Acidemia page
7 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 5 Propionic Acidemia trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- ModernaTX sponsors the most Propionic Acidemia trials on record, review their full trial history before evaluating a specific study. See ModernaTX's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Propionic Acidemia condition card totals 7 registered trials; most-linked intervention mRNA-3927; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.