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NCT05130437 · ClinicalTrials.gov registry record · Phase 1
A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study
A Phase 1 study of Propionic Acidemia, sponsored by ModernaTX.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 50
- Enrollment target
- 20
- Study locations
NCT05130437: Recruiting Phase 1 study of Propionic Acidemia, sponsored by ModernaTX.
NCT05130437 is a Phase 1 study of Propionic Acidemia that is actively recruiting participants, run by ModernaTX. The registered enrollment target is 50 participants, below the 217-participant average among 6 other Propionic Acidemia trials with a reported enrollment target (77% lower). The trial reports 20 study locations across 15 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05130437, a Phase 1 study of Propionic Acidemia, is actively recruiting participants, sponsored by ModernaTX.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 50 participants
- Enrollment target
- 20
- Study locations
Study Summary
The main purpose of this study is to evaluate the long-term safety of mRNA-3927 administered to participants with propionic acidemia (PA) who have previously participated in Study mRNA-3927-P101 (NCT04159103).
Conditions Studied
Interventions
- BIOLOGICAL mRNA-3927
Study Locations (20)
Other
- AP-HM- Hôpital de La Timone - Marseille
- Hôpital Necker - Enfants Malades - Paris
- Universitair Medisch Centrum Utrecht - PPDS - Utrecht
- Hospital Universitario 12 de Octubre - Madrid
California
- Ronald Reagan UCLA Medical Center - Los Angeles
- University of Stanford Medical Center - Palo Alto
Ar Riya
- King Faisal Specialist Hospital & Research Centre - Riyadh
- King Abdullah Children's Specialist Hospital - Riyadh
Michigan
- University of Michigan Hospitals - Ann Arbor
New York
- Icahn School of Medicine at Mount Sinai - New York
North Carolina
- Duke University Medical System (Duke Health) - Durham
Pennsylvania
- The Children's Hospital of Philadelphia (CHOP) - Philadelphia
Texas
- Texas Children's Hospital - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2021-11-09 |
| Est. Completion | 2031-12-04 |
| Phase | Phase 1 |
What NCT05130437 shows while recruiting
NCT05130437 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 217-participant average among 6 other Propionic Acidemia trials with a reported enrollment target (77% lower).
The record links to 1 condition, with Propionic Acidemia appearing as the primary indexed condition, and to 1 intervention - of which mRNA-3927 is the first listed.
NCT05130437 names 20 study sites across 15 states, led by Other, California, Ar Riya.
Frequently Asked Questions
What is clinical trial NCT05130437 about?
NCT05130437 is a clinical study titled "A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study". The main purpose of this study is to evaluate the long-term safety of mRNA-3927 administered to participants with propionic acidemia (PA) who have previously participated in Study mRNA-3927-P101 (NCT04159103).
What is the current status of trial NCT05130437?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 50 participants. The study started on 2021-11-09. Estimated completion is 2031-12-04.
What conditions does trial NCT05130437 study?
This clinical trial studies the following conditions: Propionic Acidemia.
What interventions are being tested in trial NCT05130437?
The interventions under investigation include: mRNA-3927 (BIOLOGICAL).
Who is sponsoring clinical trial NCT05130437?
This trial is sponsored by ModernaTX, which has 90 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05130437 being conducted?
This trial has 20 study locations across California, Michigan, New York, North Carolina, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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